131 citations
,
July 2009 in “Experimental Dermatology” This review discusses the development and advances in studying trichogenic dermal cells for hair follicle morphogenesis, summarizing methods, bioassays, and molecular markers, but reports no new research findings.
130 citations
,
November 2017 in “Frontiers in Immunology” This review explores recent findings on regulatory T cells, focusing on their unique functions in non-lymphoid tissues and new mechanisms of action, but presents no original clinical results.
125 citations
,
August 2020 in “Frontiers in Immunology” This review discusses sex-based differences in immune responses, focusing on genetic, hormonal, and microbiome factors influencing infections like COVID-19, and reports no clinical results.
122 citations
,
June 2020 in “Aging” This review discusses the hyperfunction theory of aging as a key factor in COVID-19 vulnerability, highlighting the potential of anti-aging interventions like rapamycin to reduce this risk.
121 citations
,
November 2020 in “Endocrine” This review discusses evidence on androgen sensitivity as a potential factor in COVID-19 disease severity, suggesting that androgen receptor interactions could influence virus entry and progression, and reports no new clinical results.
120 citations
,
February 2009 in “Apoptosis” This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.
119 citations
,
March 2020 in “Frontiers in Bioengineering and Biotechnology” This review provides an overview of recent tissue engineering and regenerative medicine developments in Asia, highlighting significant advances, representative research achievements, and discussing future directions, without presenting new research results.
113 citations
,
June 2015 in “Stem Cell Research & Therapy” This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.
112 citations
,
November 2023 in “Nano-Micro Letters” This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
107 citations
,
December 2003 in “Dermatologic Therapy” This paper reviews the use of interferons, particularly alfa interferon, in treating cutaneous T-cell lymphoma, noting its substantial efficacy both alone and in combination therapies with predictable, generally well-tolerated side effects.
104 citations
,
October 2016 in “PLoS ONE” This study found that CRISPR/Cas9-mediated disruption of the FGF5 gene in goats increased hair follicle numbers and fiber length, suggesting more cashmere production could be achieved.
103 citations
,
November 2014 in “Journal of Cell Biology” This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.
92 citations
,
December 2016 in “Scientific Reports” This study identified genomic regions and candidate genes that may contribute to phenotypic diversity in coat color, body size, cashmere traits, and high-altitude adaptation in domesticated goat breeds.
92 citations
,
November 2003 in “The Journals of Gerontology” This study indicated that while testosterone replacement in older men with low testosterone increases muscle mass and strength and reduces fat, its effects on physical function, disability, falls, or fractures remain unclear.
83 citations
,
June 2018 in “Frontiers in immunology” This review discusses the roles of αβ and γδ T cells in skin health and disease and reports no new clinical results; the authors highlight potential therapeutic developments.
83 citations
,
January 2015 in “World Journal of Stem Cells” This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.
82 citations
,
October 2019 in “Frontiers in Immunology” This review discusses the features of regulatory T cells and the modulation of Foxp3, emphasizing post-translational modifications' impact on Treg function but reports no new clinical results.
82 citations
,
August 2006 in “Pharmacology, Biochemistry and Behavior” This review proposes focusing on relationships between neuroactive steroids and psychiatric disorder symptoms, rather than relying on traditional disorder classifications, and reports no new clinical findings.
77 citations
,
March 2021 in “Nature” In this study, increased corticosterone from chronic stress prolonged hair follicle stem cell quiescence in mice, inhibiting regeneration, but restoring Gas6 expression overcame this inhibition.
77 citations
,
July 2020 in “European Journal of Clinical Pharmacology” This review explores potential early-stage pharmacologic interventions for COVID-19 by targeting virus entry into host cells, identifying several existing drugs for further investigation, but reports no new clinical results.
77 citations
,
July 2020 in “Cell” This study found that sympathetic nerves and arrector pili muscles form a niche that modulates hair follicle stem cell activity, revealing their role in hair follicle regeneration.
69 citations
,
January 2013 in “Frontiers in Immunology” This review summarizes existing knowledge on the role of FOXN1 as a key regulator of thymic epithelial cell lineage and function, reporting no new experimental results.
69 citations
,
November 2010 in “Middle East Fertility Society Journal” This review discusses the multifactorial origins and pathophysiology of PCOS and highlights the effectiveness of lifestyle modifications as a first-line intervention, reporting no new research results.
68 citations
,
May 2021 in “Endocrine” This review discusses the emerging "endocrine phenotype" of COVID-19, highlighting the implications for managing diabetes, obesity, vitamin D deficiency, and other endocrine conditions in affected patients.
68 citations
,
May 2018 in “PLOS Biology” This study demonstrates that inhibiting SFRP1 with the antagonist WAY-316606 enhances hair growth in human scalp hair follicles ex vivo by facilitating Wnt signalling.
68 citations
,
December 2014 in “Cell Biochemistry and Function” This review examines the role of nuclear hormone receptors in skin wound repair processes and reports no new clinical results, highlighting the importance of their interaction with skin cells for effective healing.
68 citations
,
April 2014 in “Journal of Molecular Endocrinology” This review summarizes existing knowledge on androgen receptor activity in breast cancer and reports no new clinical findings, with emphasis on therapies targeting androgen signaling in specific BC subtypes.
68 citations
,
June 2005 in “Expert Opinion on Therapeutic Targets” This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.
67 citations
,
December 2019 in “PloS one” This study found that beta-caryophyllene enhanced re-epithelialization in cutaneous wounds of female mice, suggesting its potential for improving wound healing through multiple pathways.
67 citations
,
August 2013 in “International Journal of Cosmetic Science” This review discusses the role of oxidative stress in hair greying and suggests that understanding melanocyte susceptibility at different follicular locations may help develop therapies for preventing and reversing the process; it reports no new experimental results.