29 citations
,
January 2010 in “Journal of oleo science” In this study, mannosylerythritol lipids from soybean oil notably increased fibroblast and papilla cell viability, suggesting potential as a hair growth agent.
July 2004 in “Journal of Clinical Oncology” This study found that therapeutic isolated limb perfusion with melphalan for in-transit melanoma metastases resulted in a high response rate but was associated with some systemic toxicity, including nausea, vomiting, and transient bone marrow depression.
September 2023 in “Journal of the American Academy of Dermatology” In this study, a cosmetic product with nano encapsulated cysteamine plus sunscreen significantly improved melasma symptoms and quality of life in adult women over 84 days, compared to sunscreen alone, without any medically relevant intolerance.
18 citations
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October 2019 in “Advanced Pharmaceutical Bulletin” This study found that finasteride microemulsions significantly increased skin permeability in vitro, highlighting the potential for enhanced delivery of this drug through the skin.
April 2019 in “Institutional Repositories DataBase (IRDB)” This study demonstrated that human iPSC-derived melanocytes, when transplanted into mice, can reconstitute pigmented hair follicles and integrate into normal tissue, suggesting their potential as a cellular therapy for depigmentation.
July 2020 in “Environmental Science and Pollution Research” This study found that finasteride and melengestrol acetate exhibit varying levels of toxicity to freshwater mussels, amphipods, and mayflies, but current environmental concentrations suggest minimal direct effects on these aquatic invertebrates.
6 citations
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August 1993 in “Archives of Dermatology” This study found that polymorphous light eruption (PLE) may include a wide range of conditions, requiring careful differentiation from similar skin disorders such as benign summer light eruption.
3 citations
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May 2019 in “Journal of Cosmetic Dermatology” This study found that a 12-week supplementation with MePL, a solution of miliacin encapsulated within polar lipids, significantly reduced hair density in the telogen phase and improved scalp dryness and hair brightness in women with telogen effluvium.
5 citations
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October 2021 in “Journal of the American Academy of Dermatology” PRAME helps distinguish between benign and malignant skin cells in most cases.
11 citations
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August 2006 in “Cell Biology International” This study found that endothelin-1 increases adhesion and chemotaxis of amelanotic melanocytes on fibronectin, laminin, and collagen IV, potentially through changes in the actin cytoskeleton.
This study found that human placental extract significantly improved melasma, chronic ulcers, and alopecia areata without major adverse effects, suggesting its effectiveness and safety for these conditions.
57 citations
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February 1994 in “Experimental dermatology” This study found that murine skin is a target for melatonin bioregulation, as melatonin affected DNA synthesis and tyrosinase activity in skin organ culture.
53 citations
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July 1981 in “Journal of Endocrinology” In this study, α-MSH and cyclic AMP were found to stimulate melanogenesis in hair follicle cultures, while cyclic GMP and melatonin inhibited melanin production but not tyrosinase activity.
118 citations
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January 1992 in “Experientia”
11 citations
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May 2021 in “Journal of Cosmetic Dermatology” This review discusses the potential use of platelet-rich plasma for treating melasma, suggesting its effectiveness but noting the need for more extensive studies to confirm these findings.
July 2004 in “Journal of Clinical Oncology” This study found therapeutic isolated limb perfusion with melphalan to be effective for in-transit melanoma metastases on a limb, with a high response rate and transient systemic toxicity.
The digital system for measuring melasma shows promise but needs more development for better accuracy and automation.
December 2025 in “Biomedicine & Pharmacotherapy” This study found that Melamax®, originally developed as an eco-friendly hair dye, provides significant protection against ultraviolet-induced oxidative and inflammatory damage in keratinocytes by modulating gene expression and signaling pathways, highlighting its dual potential for cosmetic coloration and skin photoprotection.
May 2022 in “Research Square (Research Square)” Melatonin improved sheep reproduction, being more beneficial and cost-effective in males.
January 2016 in “UNESP Institutional Repository (São Paulo State University)” This study suggests that the phenotype of melasma in women is influenced by structural and cellular changes across the epidermal-melanin unit, not just melanocyte hypertrophy, highlighting potential roles for dermal damage repair and fibroblast senescence.
This study found that melatonin may enhance hair growth properties in dermal papilla cells by activating the AKT/GSK3β/β-catenin signaling pathway through melatonin receptors.
June 2010 in “Melanoma research” This study found that LDE225, a novel Smo antagonist, shows potential as a topical treatment for basal cell carcinoma due to its high affinity binding and effective inhibition of tumor growth in preclinical models.
12 citations
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September 2018 in “International Journal of Cosmetic Science” This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.
This protocol outlines a study to evaluate whether photobiomodulation, alone or with melatonin, promotes hair regrowth in dogs with Alopecia X, reporting no new results yet.
3 citations
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July 2024 in “Cureus” In this study, PRP was found to show promise in treating melasma, offering consistent positive outcomes and satisfaction rates among patients, especially when combined with treatments like hydroquinone and tranexamic acid, though further research is needed to confirm long-term efficacy and safety.
September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study developed a biobased copolymer called SELP::KP, showing improved hair strength, elasticity, and conditioning properties while being a safer alternative to conventional chemical treatments, based on application to human hair in a laboratory setting.
May 2025 in “Veterinary Medicine and Science” In this study, oral melatonin given to male Pomeranian dogs with Alopecia X improved semen quality and testicular blood flow in a dose-dependent manner, but altered hormonal balance, indicating complex effects that require further investigation for long-term implications.
3 citations
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November 2024 in “Pediatric Dermatology” This study found that dermatologic adverse events are common in children taking MEK inhibitors, with selumetinib patients experiencing less severe reactions and a lower risk of dosage adjustments. Age was noted as a factor in the likelihood of specific skin reactions.
2 citations
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January 2018 in “Biomolecules & therapeutics” This study found that polyamidoamine dendrimers can permeate skin's current conducting pores and alter the magnitude and direction of electroosmotic flow, affecting drug flux during iontophoresis.
15 citations
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April 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that A(3)B(5) downregulates melanin production and suppresses melanoma cell growth by promoting proteasomal degradation of TRP-2.