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300-330 / 1000+ resultsresearch Single-Administration Long-Acting Microarray Patch with Ultrahigh Loading Capacity and Multiple Releases of Thermally Stable Antibodies
This study demonstrated that a microarray patch can deliver antibodies in a controlled and prolonged manner, maintaining their functionality after manufacturing and heat exposure, with successful pharmacokinetic proof-of-concept in rats.
research Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design
This study reported that structure-guided engineering of CYP154C2 mutants significantly improved the 2α-hydroxylation of androstenedione and testosterone, with enhanced conversion efficiency and substrate selectivity compared to the wild-type enzyme.
research A Reappraisal of the Antiviral Properties of and Immune Regulation through Dietary Phytochemicals
This review discusses the potential of plant-derived natural compounds with immunomodulatory properties as novel antiviral therapies, highlighting their possible mechanisms against various viral infections in the context of traditional and biotechnological applications.
research Network pharmacology and molecular docking analysis on potential molecular targets and mechanism of action of BRAF inhibitors for application in wound healing
This study suggests that BRAF inhibitors, particularly Encorafenib and Dabrafenib, may have potential applications in wound healing by targeting specific proteins involved in the healing process in murine models.
research Bioelectronic devices for light-based diagnostics and therapies
This review discusses recent advancements in light-based bioelectronic devices for health monitoring and therapy, summarizing key technologies and highlighting challenges and opportunities without reporting new clinical results.
research Small animal models of thermal injury
research “Osler’s phenomenon”: misdiagnosing Cushing’s syndrome
This study described four cases of delayed diagnosis of Cushing’s syndrome, highlighting that increased clinical awareness and screening could reduce its associated morbidity and mortality.
research Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function
This study found that deleting specific super-enhancer regions in mice affects CD25 expression in a cell type-specific manner, leading to autoimmune alopecia in some cases and revealing distinct regulatory mechanisms for constitutive and inducible expression of CD25.
research Human retinal secretome: A cross-link between mesenchymal and retinal cells
This review discusses the interaction between mesenchymal stem cell secretomes and retinal cell secretomes, suggesting their potential in experimental therapies to protect and regenerate retinal tissue.
research Comparing the burden of illness in patients with alopecia areata vs atopic dermatitis in the US population from a payer perspective
This study found that patients with alopecia areata had similar total health care costs as those with atopic dermatitis, despite having fewer comorbidities and prescription medications overall.
research Alopecia Areata: A Review of the Genetic Variants and Immunodeficiency Disorders Associated with Alopecia Areata
This review discusses the histological features and diagnostic challenges of alopecia areata and emphasizes the need for genetic research to develop future therapeutics; it reports no new clinical findings.
research Efficacy of serum anti-mullerian hormone (AMH) levels for prediction of polycystic ovary syndrome (PCOS) and its association with clinical, biochemical and hormonal parameters
research Rice bran as a potent ingredient: unveiling its potential for value-added applications
research Advancing immunotherapy using biomaterials to control tissue, cellular, and molecular level immune signaling in skin
research Insights Into the Cardiomodulatory Effects of Sex Hormones: Implications in Transgender Care
This review highlights the association between gender-affirming hormone therapy and increased cardiovascular risk among transgender individuals, emphasizing the need for cardiovascular-focused clinical management and further research to inform and educate both clinicians and patients.
research Assessing tolerability and physiological responses to 17α-estradiol administration in male rhesus macaques
research The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages
This review discusses molecular regulatory circuitry in organ regeneration, using skin regeneration examples, and reports no new experimental results; the authors propose that understanding this circuitry might aid in developing therapeutic strategies.
research Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding
research Interventions for preventing the progression of autosomal dominant polycystic kidney disease
This review found that Tolvaptan is the only drug shown to slow the progression of autosomal dominant polycystic kidney disease, but it does not affect mortality or kidney failure outcomes.
research Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism.
research Tranexamic acid reduces inflammation, edema and burn wound conversion in a rodent model
research Organ function is preserved despite reorganization of niche architecture in the hair follicle
research Novel aldo-keto reductase 1C3 inhibitor affects androgen metabolism but not ovarian function in healthy women: a phase 1 study
This study identified serum androsterone as a robust biomarker for monitoring response to AKR1C3 inhibitor treatment in women and found that a 4-week administration of aldo-keto reductase 1C3 inhibitors did not impact ovarian function.
research Impact of Topical Vehicles and Cutaneous Delivery Technologies on Patient Adherence and Treatment Outcomes in Acne and Rosacea.
This review discusses emerging drug delivery technologies and formulations for acne and rosacea, noting that microencapsulation enables combining benzoyl peroxide and tretinoin to enhance tolerability and prevention of oxidation.
research JAK Inhibitors: A New Weapon in the Skin Care Providers' Arsenal.
This review discusses JAK inhibitors as promising new treatments for various chronic dermatologic conditions, including some recent drug approvals, and reports no new clinical results.
research Parallels in signaling between development and regeneration in ectodermal organs
research Discovery of Orally Available Prodrugs of Itaconate and Derivatives
This study identified orally available itaconate derivatives that improve cellular permeability and bioavailability, with specific POC-based prodrugs showing significant inhibition of inflammatory cytokines in human epidermal keratinocytes and favorable oral pharmacokinetics, highlighting their potential for treating systemic and skin disorders.
research Post bariatric surgery complications, nutritional and psychological status.
This study found that bariatric surgery led to significant weight loss in patients, but it also resulted in complications like nutrient deficiencies, highlighting the need for dietary compliance and professional follow-up.