research Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials
Antiandrogens are somewhat effective in reducing excessive hair growth in women.
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research A Prospective Study of the Prevalence of Nonclassical Congenital Adrenal Hyperplasia Among Women Presenting with Hyperandrogenic Symptoms and Signs
About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.
research Theoretical Considerations in Laser Hair Removal
Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.
research Transdermal Permeation of Drugs in Various Animal Species
Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.
research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle
The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.
research Trilostane Treatment of 78 Dogs With Pituitary-Dependent Hyperadrenocorticism
Trilostane effectively improved symptoms in dogs with a certain adrenal gland disorder.
research Alopecia Areata: A Multifactorial Autoimmune Condition
Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
research The Immune Functions of Keratinocytes in Skin Wound Healing
Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
research Fibroblasts and Wound Healing: An Update
Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.
research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling
Cathepsin L is essential for normal hair growth and development.
research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing
The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.
research Increased Copy Number of the TERT and TERC Telomerase Subunit Genes in Cancer Cells
Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.
research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside
Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.
research WNT Signaling in Disease
The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.
research Age-Associated Inflammation Inhibits Epidermal Stem Cell Function
Aging causes skin stem cells to work less effectively.
research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia
Too much androgen can cause hair loss; finasteride may help.
research Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development
The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.
research Pathophysiological Mechanisms Implicated in Postpartum Depression
Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.
research Pharmacokinetics, Toxicity, and Activity of Intravenous Dextran Sulfate in Human Immunodeficiency Virus Infection
Dextran sulfate was found to be toxic and ineffective for treating HIV.
research Molecular Mechanisms of Viral Oncogenesis in Humans
Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.
research Epithelial-To-Mesenchymal Transition in Cutaneous Wound Healing: Where We Are and Where We Are Heading
The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.
research Dermatological Adverse Events with Taxane Chemotherapy
Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.
research Prevalence of Dermatological Disorders in Japan: A Nationwide, Cross-Sectional, Seasonal, Multicenter, Hospital-Based Study
Eczema and fungal infections are the most common skin problems in Japan, with different age groups and genders affected by various conditions.
research A Perspective on RNAi-Based Biopesticides
RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.
research Microneedles as the Technique of Drug Delivery Enhancement in Diverse Organs and Tissues
Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.
research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues
Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.
research Mechanical and Biological Properties of Keratose Biomaterials
Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.
research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
research Signaling in the Stem Cell Niche: Regulating Cell Fate, Function, and Plasticity
The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.
research Vitamin D and the Skin: Focus on a Complex Relationship
Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.