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17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

Pannexin 3 helps skin and hair growth by controlling a protein called Epiprofin.

Not enough evidence to support using platelet rich plasma for hair loss treatment.

H-1 antihistamines may help with various skin conditions, but more research is needed to confirm their effectiveness.

Medications for PCOS don't seem to raise heart disease risk.

Dermal macrophages might help regrow hair.

The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The Rotterdam Study aims to understand various diseases in older adults.

Targeted cancer therapies often cause serious skin problems that need careful management.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Wool follicles are complex, involving interactions between different cell types and structures.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

A new gene, JMJD1C, may affect testosterone levels in men.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

A20 protein is crucial for normal skin and hair development.