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Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Teriflunomide helps reduce multiple sclerosis symptoms and is safe for most patients.

Human skin can make serotonin and melatonin.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

The Rotterdam Study aims to understand various diseases in older adults.

Targeted cancer therapies often cause serious skin problems that need careful management.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Some medicinal plants can help heal wounds and may lead to new treatments.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.

Masculine facial features may not reliably indicate heritable health, and more research is needed.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.