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Glossary Platelets

small blood cell fragments crucial for clotting and wound healing

Platelets, also known as thrombocytes, are small, disc-shaped cell fragments in the blood that are crucial for clotting. When a blood vessel is injured, platelets gather at the site and form a plug to help stop bleeding, releasing chemicals that further the clotting process.

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research Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

848 citations , October 2020 in “International Journal of Molecular Sciences”

This review discusses the potential of platelet-rich plasma applications in regenerative medicine and explores recent progress and challenges in translating non-clinical PRP findings into human treatments, but reports no new clinical results.

research A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

348 citations , July 2017 in “Skin appendage disorders”

This review discusses the use of platelet-rich plasma in dermatology for various applications such as tissue regeneration and wound healing, but it reports no new clinical results and calls for clearer guidance on suitable treatments.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

This study found that platelet-rich plasma injections significantly increased hair count and density in patients with male pattern hair loss without major side effects, suggesting it may be a safe and effective treatment option.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata

205 citations , April 2013 in “British Journal of Dermatology”

In this study, platelet-rich plasma significantly increased hair regrowth and reduced symptoms of alopecia areata compared to triamcinolone acetonide or placebo, with no observed side effects.

The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

research The Effect of Autologous Activated Platelet Rich Plasma (AA-PRP) Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

This study reported that AA-PRP injections significantly increased hair count and density in individuals with pattern hair loss compared to baseline, demonstrating their potential for enhancing hair growth.

research Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

169 citations , January 2020 in “Burns & Trauma”

In this study, autologous platelet-rich plasma improved skin wound healing in mice, associated with reduced inflammation and enhanced angiogenesis and re-epithelialization, but the underlying regulatory mechanism requires further investigation.

research Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth

166 citations , August 2011 in “Dermatologic Surgery”

This study found that PRP combined with dalteparin and protamine microparticles may enhance hair growth by increasing hair thickness compared to PRP alone.

Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

research Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period

164 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that PRP injections may improve hair density and reduce hair loss in patients with androgenetic alopecia without significant side effects, but further research is needed to confirm efficacy.

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

This study found that platelet-rich plasma significantly increased hair density and anagen hair proportions in androgenetic alopecia patients, suggesting potential as an adjuvant therapy.

Platelet-Rich Plasma in Dermatology: Boon or Bane?

research Platelet-rich plasma in dermatology: Boon or a bane?

119 citations , January 2014 in “Indian Journal of Dermatology, Venereology and Leprology”

This review discusses the use of platelet-rich plasma in various dermatological applications and reports no new clinical results; the authors call for more rigorous trials to confirm its effectiveness.

research Systematic Review—The Potential Implications of Different Platelet-Rich Plasma (PRP) Concentrations in Regenerative Medicine for Tissue Repair

115 citations , August 2020 in “International Journal of Molecular Sciences”

This systematic review indicates that a platelet-rich plasma concentration of 1.0 × 10^6 plt/μL may be optimal for tissue regeneration due to sufficient nutrition supply and effective growth factor diffusion in vivo.

Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool

research Platelet-rich plasma in androgenic alopecia: Myth or an effective tool

115 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

In this study, PRP injections increased hair count and reduced hair loss in patients with androgenic alopecia not responding to minoxidil and finasteride, with high patient satisfaction reported.

research Systematic review of the use of platelet-rich plasma in aesthetic dermatology

113 citations , July 2015 in “Journal of Cosmetic Dermatology”

This review discusses the cosmetic applications of platelet-rich plasma in dermatology, highlighting its potential benefits and the need for more controlled studies.

research Platelet-Rich Plasma for Androgenetic Alopecia

107 citations , August 2014 in “Dermatologic Surgery”

This pilot study suggests injecting platelet-derived growth factors into the scalp may offer some clinical benefits for androgenetic alopecia, though further randomized trials are needed for confirmation.

Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

research Combined autologous platelet-rich plasma with microneedling verses microneedling with distilled water in the treatment of atrophic acne scars: a concurrent split-face study

106 citations , January 2016 in “Journal of Cosmetic Dermatology”

This study found that adding platelet-rich plasma to microneedling improved outcomes for atrophic acne scars more than microneedling alone, according to both quantitative and qualitative assessments.

research The effect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study

88 citations , December 2012 in “Journal of The European Academy of Dermatology and Venereology”

This study found that interfollicular injection of autologous CD34+ cell-containing PRP preparation improved hair count and thickness in patients with pattern hair loss, with better results than placental extract treatment.

research Platelet‐rich plasma and regenerative dentistry

87 citations , March 2020 in “Australian Dental Journal”

This review discusses different preparation and application methods of platelet-rich plasma in dental regenerative medicine and reports no new results, highlighting its potential and associated controversies.

research Applications of platelet-rich plasma in dermatology: A critical appraisal of the literature

79 citations , October 2015 in “Journal of Dermatological Treatment”

This review assesses the use of platelet-rich plasma in dermatology and concludes that while there may be modest benefits for certain conditions, more evidence is needed before it can be widely recommended.

research The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review

76 citations , December 2018 in “Aesthetic Plastic Surgery”

This review discusses various aesthetic and regenerative applications of platelet-rich plasma and concludes that it has potential as a safe cosmetic intervention but requires further studies to understand its clinical effects.

research Efficacy of platelet-rich plasma in treatment of androgenic alopecia

74 citations , January 2015 in “Asian Journal of Transfusion Science”

This study found that platelet-rich plasma injections led to improvements in hair counts, thickness, and strength in patients with androgenic alopecia, showing promise as an effective treatment with no major adverse effects.

Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

research Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

70 citations , February 2021 in “International Journal of Molecular Sciences”

This review provides an overview of current research on AD-MSCs, PRP, and biomaterials, highlighting their safety and efficacy in treating soft tissue defects and chronic wounds without major side effects.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation

69 citations , April 2019 in “Biomedicines”

This study found that hair thickness and density increased after treatment with human follicle mesenchymal stem cells and platelet rich plasma, associated with enhanced Wnt signaling and platelet derived growth factors.

research Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

66 citations , June 2015 in “Aesthetic Plastic Surgery”

This review of 47 studies indicates that platelet preparations may significantly enhance cellular activity, wound healing, and facial aesthetic outcomes in facial plastic surgery, though potential publication bias should be considered.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil®, Finasteride®, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

This review indicates that most studies reported positive effects of platelet-rich plasma injections for treating androgenic alopecia, with no major side effects, suggesting it may be a safe alternative to Minoxidil and Finasteride.