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The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Different types of stem cells and their environments are key to skin repair and maintenance.

Microneedles help improve skin appearance and deliver skin treatments effectively, but safety concerns need more research and regulation.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.

One minoxidil-sensitive potassium channel exists in human hair follicles.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

Blocking β-catenin in skin cells improves hair growth during wound healing.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

Mutant mice help researchers understand hair growth and related genetic factors.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Dermal papilla cells help wounds heal better and can potentially grow new hair.

The conclusion is that Fgf18 and Tgf-ß signaling could be targeted for hair loss treatments.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.