13 citations
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June 2020 in “Stem Cells International” In this study using a mouse model, ECM/SVF-CM, derived from adipose-derived stem cells, was observed to stimulate hair growth more effectively than SVF-CM by promoting cell proliferation, neovascularization, and anagen induction, which may support its potential as an improved treatment for hair loss.
2 citations
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January 2016 in “Springer eBooks” This review discusses the potential of adipose-derived stem cells for regenerative medicine, highlighting their ability to differentiate, secrete factors, and modulate the immune response, but reports no new findings.
17 citations
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March 2021 in “Expert Opinion on Biological Therapy” This review analyzes the impact of different preparation methods for platelet-rich plasma, human follicles stem cells, and adipose-derived stem cells on hair regrowth and wound healing, but reports no new results; the authors emphasize convincing evidence of positive outcomes despite protocol variability.
June 2026 in “Nano Research” In this study, researchers developed a novel 3D bio-printed skin scaffold using exosomes from liver cells, which enhanced wound healing by promoting cell growth, angiogenesis, and reducing inflammation in large skin injuries, suggesting potential applications in treating chronic skin conditions.
2 citations
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September 2022 in “Organoid” In this study, the researchers developed a new protocol using human-induced pluripotent stem cells to efficiently create skin hair follicle organoids, which may aid in optimizing hair follicle growth and exploring treatments for alopecia.
42 citations
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February 2017 in “Scientific Reports” In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.
12 citations
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September 2020 in “Nanomaterials” This study found that centrifugally spun scaffolds with higher concentrations of platelet-derived bioactive molecules enhanced melanocyte metabolic activity and proliferation, suggesting potential for improving vitiligo treatment.
4 citations
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April 2012 in “Asian-australasian Journal of Animal Sciences” This study found that applying deer antler extract to rat skin wounds enhanced hair growth and increased IGF-I expression, suggesting potential use in hair growth products.
60 citations
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February 2015 in “Biomaterials” In this study, immobilized VEGF selectively captured endothelial cells under various shear stresses, suggesting its potential for promoting endothelialization in vascular grafts or implanted tissues.
6 citations
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August 2022 in “International journal of molecular sciences” This study demonstrated that α-phellandrene promotes dermal papilla cell proliferation through a cAMP-mediated pathway and upregulates VEGF expression, suggesting its potential use in hair loss prevention.
24 citations
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November 2013 in “Molecular Medicine Reports” This study demonstrated that human hair follicle stem cells can be efficiently differentiated into endothelial-like cells using VEGF and bFGF, suggesting their potential as a novel cell source for vascular tissue engineering.
5 citations
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January 2022 in “Molecular Medicine Reports” In this study, topical application of Korean maritime pine bark extract at 2% concentration significantly promoted hair growth in mice, suggesting its potential use for hair loss prevention or treatment.
3 citations
,
August 2022 in “International Journal of Molecular Sciences” This review discusses the increased incidence of hair loss and telogen effluvium among COVID-19 patients and evaluates existing evidence for regenerative treatments like PRP and HFSCs, finding limited published data.
June 2025 in “Stem Cell Research & Therapy” This study found that administering adipose-derived stem cells with ATP improved hair regrowth in male mice with androgenetic alopecia, while the combination was less effective in female mice.
7 citations
,
September 2017 in “Biomedical and Pharmacology Journal” This article discusses the early development of hair follicles with a focus on the formation of epidermal thickenings called placodes, reporting no new experimental results.
5 citations
,
March 2017 in “Biomedical and Pharmacology Journal” This article discusses the concept of telogen effluvium, introduced in 1961, characterized by diffuse scalp hair loss due to various triggers, and reports no new clinical findings.
September 2025 in “Current Issues in Molecular Biology” This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.
January 2024 in “Skin appendage disorders” This article reviews existing research on the treatment of alopecia areata using growth factors and microneedling, reporting that these methods show promise in promoting hair growth without major adverse effects, but emphasizes the need for additional large-scale studies to confirm their efficacy and safety.
51 citations
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April 2020 in “Cells” This study found that macrophage extracellular vesicles enriched with Wnt proteins significantly promoted hair follicle growth in mice and increased hair shaft size in human hair follicles, suggesting potential clinical use for treating hair loss.
6 citations
,
October 2024 in “Frontiers in Bioengineering and Biotechnology” This study reported that the use of composite RGDmix hydrogel improved the survival and proliferation of human amniotic mesenchymal stem cells and increased growth factor expression, enhancing wound healing through the RGDSP/integrin αv/PI3K/AKT signaling pathway.
August 2024 in “Journal of Cosmetic Dermatology” This study reported significant improvements in hair density and growth ratio in androgenetic alopecia patients receiving concentrated growth factor injections, with benefits sustained for 6 months.
3 citations
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September 2024 in “International Journal of Molecular Sciences” This review examines how mathematical modeling of the MAPK pathway, enhanced by single-cell proteomic data, improves understanding of regulatory mechanisms, predicts system behavior, and guides experimental research, emphasizing recent developments in modeling and inference.
9 citations
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September 2024 in “Frontiers in Endocrinology” This study found that intrauterine PRP infusion is a safe and effective treatment for patients with refractory thin endometrium and implantation failures, with the improvement primarily driven by the angiogenic cytokines in PRP.
9 citations
,
March 2019 in “Molecular & cellular proteomics” In this study, around 1% of proteins in skin fibroblasts significantly changed in response to reductive stress, affecting collagens and MAPK signaling pathways.
29 citations
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January 2021 in “Journal of nanobiotechnology” In this study, exosome-mimetic nanovesicles derived from neural progenitor cells promoted hair follicle regeneration in mice by activating the Wnt/β-catenin signaling pathway.
August 2023 in “Journal of analytical & pharmaceutical research” In this study, microneedle-assisted human basic fibroblast growth factor therapy was reported to significantly improve hair regeneration in both male and female patients with androgenetic alopecia, alopecia areata, and telogen effluvium, showing greater effectiveness in males.
January 2015 in “Surgical and Cosmetic Dermatology” This study reported effective hair growth improvement in androgenic alopecia through subcutaneous injections of platelet-rich plasma, with observed benefits in both women and men.
14 citations
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October 2017 in “European Journal of Medical Research” In this study, platelet-rich plasma injections in mice promoted hair growth and angiogenesis compared to control, as evidenced by longer hair lengths and increased vessel formation.
1 citations
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August 2022 in “International Journal of Molecular Sciences” In this study, FGF12 was found to promote hair growth in mice by inducing the anagen phase of hair follicles, suggesting potential for hair loss therapy.
January 2020 in “Global dermatology” This study found that iontophoresis with growth factor cocktail including fibroblast growth factor 5-short significantly increased hair density in patients with androgenetic alopecia over 24 weeks.