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GlossaryPlatelet-Derived Growth Factor AA

stimulates cell growth and tissue repair, including hair follicles

Platelet-Derived Growth Factor AA (PDGF-AA) is a protein that plays a crucial role in cell growth, healing, and development. It is one of the isoforms of PDGF, which are important for stimulating the proliferation and differentiation of cells, particularly in the context of wound healing and tissue repair. In the realm of hair biology, PDGF-AA can influence hair follicle development and regeneration, making it a potential target for treatments related to hair loss and alopecia.

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research Hair, Cutaneous Homeostasis and Stem Cell Functions

January 2014 in “Journal of Investigative Dermatology”

Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.

research Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells

17 citations , February 2015 in “International Journal of Molecular Sciences”

A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.

research Expression of CD117 and platelet-derived growth factor receptor α in patients with alopecia areata

1 citations , January 2020 in “Indian journal of dermatology, venereology, and leprology”

CD117 and platelet-derived growth factor receptor α may play a role in alopecia areata.

research Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers

2 citations , December 2019 in “FEBS open bio”

Combining specific inducers helps dermal papilla cells regain hair-forming ability.

Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Novel therapeutic approaches in utilizing platelet lysate in regenerative medicine: Are we ready for clinical use?

51 citations , March 2019 in “Journal of cellular physiology”

Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

90 citations , October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation

69 citations , April 2019 in “Biomedicines”

PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

research Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell

9 citations , June 2020 in “Tissue Engineering and Regenerative Medicine”

HHORSC exosomes and PL improve hair growth treatment outcomes.

research Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

88 citations , March 2019 in “Journal of Tissue Engineering and Regenerative Medicine”

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

research Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics

13 citations , July 2022 in “Frontiers in cell and developmental biology”

Tiny natural vesicles from cells might help treat hair loss.

research Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth

21 citations , January 2018 in “The Korean Journal of Physiology and Pharmacology”

Modified stem cells from umbilical cord blood can make hair grow faster.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations , June 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis

106 citations , December 2016 in “Cell Stem Cell”

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

research A study of the effects of physical dermabrasion combined with chemical peeling in porcine skin

5 citations , October 2014 in “Journal of cosmetic and laser therapy”

Combining physical dermabrasion with chemical peeling is more effective for skin treatment than chemical peeling alone.

research The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

68 citations , December 2018 in “Trends in Cell Biology”

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

research Effect of platelet counts and activator in platelet-rich plasma on the treatment of androgenetic alopecia, split-head comparison: A randomised, double-blind study

January 2023 in “Indian Journal of Dermatology, Venereology and Leprology”

research Mesenchymal Stem Cell Secretome for Dermatology Application: A Review

26 citations , October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

The secretome from mesenchymal stem cells shows promise for treating skin conditions and improving skin and hair health, but more research is needed.

Soy protein/β-chitin sponge-like scaffolds laden with human mesenchymal stromal cells from hair follicle or adipose tissue promote diabetic chronic wound healing

research Soy protein/β-chitin sponge-like scaffolds laden with human mesenchymal stromal cells from hair follicle or adipose tissue promote diabetic chronic wound healing

1 citations , December 2023 in “Biomaterials advances”

Sponges made of soy protein and β-chitin with human cells from hair or fat can speed up healing of chronic wounds.

research Brain-derived nerve factor and neurotrophins in androgenetic alopecia

10 citations , November 2011 in “British Journal of Dermatology”

Lower growth factors linked to balding in androgenetic alopecia.

HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i>

research HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells in vitro

7 citations , March 2021 in “Molecular Medicine Reports”

A mix of specific inhibitors and a growth factor helps keep hair growth cells from losing their properties in the lab.

research Role of Growth Factors-Rich Plasma, Gel and Membrane in Dermal Wound Healing and Injured Tissue Restoration and Regeneration

1 citations , November 2021 in “European journal of medical and health sciences”

Growth factors-rich plasma treatments can significantly speed up wound healing and tissue regeneration.

research Problems and Solutions for Platelet-Rich Plasma in Facial Rejuvenation: A Systematic Review

20 citations , October 2018 in “Aesthetic Plastic Surgery”

PRP shows promise for improving facial wrinkles, skin elasticity, and hair growth, but more research is needed to standardize its use and understand its effects.

research Hair Growth Promoting Effect of <i>Hottuynia cordata</i> Extract in Cultured Human Hair Follicle Dermal Papilla Cells

16 citations , October 2019 in “Biological & Pharmaceutical Bulletin”

Houttuynia cordata extract may help hair grow by improving cell survival and increasing cell growth.

research Alopecia areata: a review on diagnosis, immunological etiopathogenesis and treatment options

56 citations , January 2021 in “Clinical and Experimental Medicine”

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

research Modulation of Hair Growth Promoting Effect by Natural Products

7 citations , December 2021 in “Pharmaceutics”

Natural products like plant extracts can help promote hair growth and could be used to treat hair loss.

research Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review

2 citations , October 2022 in “Journal of Biomedical Science”

Stem cells and their secretions could potentially treat stress-induced hair loss, but more human trials are needed.

research The PDGF/PDGFR pathway as a drug target

182 citations , August 2018 in “Molecular Aspects of Medicine”

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

research The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier

23 citations , December 2021 in “Frontiers in Immunology”

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

research Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

19 citations , May 2020 in “Cells”

Substance from human umbilical cord blood cells promotes hair growth.