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    Glossary Platelet-Derived Growth Factor AA

    stimulates cell growth and tissue repair, including hair follicles

    Platelet-Derived Growth Factor AA (PDGF-AA) is a protein that plays a crucial role in cell growth, healing, and development. It is one of the isoforms of PDGF, which are important for stimulating the proliferation and differentiation of cells, particularly in the context of wound healing and tissue repair. In the realm of hair biology, PDGF-AA can influence hair follicle development and regeneration, making it a potential target for treatments related to hair loss and alopecia.

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    1. The effect of platelet-derived growth factor-aa (PDGFA) conjugated with low-molecular-weight protamine (LMWP) on hair loss improvement effect Biochemical and Biophysical Research Communications · 2024
    2. Signaling by the Platelet-Derived Growth Factor Receptor Family 2009
    3. The Combined Use of Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Promotes Healing. A Review of Experimental Models and Future Perspectives Biomolecules · 2021 · 4 citations
    4. Generation of trichogenic adipose-derived stem cells by expression of three factors Journal of Dermatological Science · 2018 · 12 citations
    5. Alopecia and platelet-derived therapies Stem cell investigation · 2017 · 23 citations
    6. Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells International Journal of Molecular Sciences · 2015 · 17 citations
    7. 690 Platelet activation during PRP preparation for therapeutic use Journal of Investigative Dermatology · 2024
    8. PDGFA in Cashmere Goat: A Motivation for the Hair Follicle Stem Cells to Activate Animals · 2019 · 19 citations
    9. Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers FEBS open bio · 2019 · 2 citations
    10. Shaping Up Mitochondrion in Motion Dermatology - Open Journal · 2016 · 1 citations
    11. Hair, Cutaneous Homeostasis and Stem Cell Functions Journal of Investigative Dermatology · 2014
    12. PDGF isoforms induce and maintain anagen phase of murine hair follicles Journal of Dermatological Science · 2006 · 136 citations
    13. 174 Dermis-hair follicle communication: Extracellular microvesicles signaling for hair regeneration Journal of Investigative Dermatology · 2020
    14. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    15. Evaluation of intralesional injection of platelet derived growth factors PDGF ma in patients with Peyronie's disease 2025
    16. Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal npj Regenerative Medicine · 2017 · 37 citations
    17. Platelet Concentrates in Regenerative Medicine: A Comparative Review of Platelet-Rich Plasma, Platelet-Rich Fibrin, and Concentrated Growth Factors Trends in Sciences · 2026
    18. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    19. Expression of CD117 and platelet-derived growth factor receptor α in patients with alopecia areata Indian journal of dermatology, venereology, and leprology · 2020 · 1 citations
    20. Enriched-GF: A Reproducible High-Yield Autologous Blood-Derived Growth Factor Method for Regenerative Medicine bioRxiv (Cold Spring Harbor Laboratory) · 2026
    21. The Growth Factors in Advanced Platelet-Rich Fibrin (A-PRF) Reduce Postoperative Complications after Mandibular Third Molar Odontectomy International Journal of Environmental Research and Public Health · 2021 · 23 citations
    22. Progenic hair regrowth treatment- The use of platelet-released growth factors for treating androgenetic alopecia (AGA) by activating hair follicle stem cells Journal of clinical & experimental dermatology research · 2014
    23. The Impact of Growth Factors in Platelet‐Rich Plasma Combination Therapy for Androgenic Alopecia Dermatologic Therapy · 2024
    24. Investigation of the effect of anticoagulants on platelet recovery, enrichment factor, PDGF, TGF-β1 and optimal dose in the preparation of platelet-rich plasma Research Square (Research Square) · 2023
    25. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019 · 136 citations
    26. Platelet-rich Plasma for Hair Growth Advances in Cosmetic Surgery · 2019 · 1 citations
    27. A pilot study on relationship between quantity of growth factors and cytokines to blood groups in umbilical cord blood-derived PRP Journal of 108 - Clinical Medicine and Phamarcy · 2025
    28. Can Plasma Rich in Growth Factors Be Safe for Parental Use? A Safety Study in the Canine Model International Journal of Molecular Sciences · 2018 · 6 citations
    29. An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome Journal of Clinical Medicine · 2023 · 6 citations
    30. Role of Growth Factors-Rich Plasma, Gel and Membrane in Dermal Wound Healing and Injured Tissue Restoration and Regeneration European journal of medical and health sciences · 2021 · 1 citations