51 citations
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March 2019 in “Journal of cellular physiology” This review discusses the use of platelet lysate and its growth factors in treating diseases and regenerative medicine but reports no new clinical findings.
13 citations
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January 2021 in “Regenerative Medicine” This review examines the potential applications of human platelet lysates in regenerative medicine but reports no new experimental findings.
2 citations
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July 2025 in “Cells” This study reports that human adipose-derived stem cells cultured with platelet lysate instead of fetal bovine serum demonstrate enhanced stress resistance, reduced cellular aging, and faster wound healing in mice, due in part to upregulated stress response and proliferation genes.
2 citations
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March 2023 in “Biomedicine & pharmacotherapy” This study found that platelet lysate significantly improved hair growth and follicle performance in both experimental settings and AGA patients, showing results comparable to platelet-rich plasma.
February 2020 in “Int J Biologicals” This study found that super-activated platelet lysate increased hair follicle density in a mouse model of androgenetic alopecia, outperforming platelet-rich plasma and platelet lysate.
11 citations
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October 2016 in “Biomedicine & Pharmacotherapy” In this study, minoxidil and human platelet lysate affected gene expression related to hair growth signaling pathways in mouse hair follicle cells.
February 2025 in “Drug Delivery and Translational Research” 
23 citations
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November 2017 in “Stem cell investigation” This study found that platelet lysate produced higher follicular regeneration in hair restoration surgeries compared to activated PRP and saline, with significant gains in both follicular unit and hair density.
January 2026 in “RSC Advances” This study found that the natural polymer-based hydrogel Gel/SA@PL released growth factors in a controlled way, which enhanced tissue regeneration and minimized scarring in the healing of diabetic wounds.
July 2023 in “BENTHAM SCIENCE PUBLISHERS eBooks” This book chapter reviews the subclasses and applications of platelet-rich plasma in tissue engineering and highlights the challenges in clinical translation without reporting new clinical results.
2 citations
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July 2024 in “Bioengineering” This study found that platelet-rich fibrin lysates modulate chemokine expression, reducing inflammation in oral squamous carcinoma cells, but increasing expression in primary oral epithelial cells.
February 2024 in “Asian Journal of Pharmaceutical and Clinical Research” This study found that human platelet lysate, prepared from expired platelet concentrate, maintained stable growth factor levels for up to six months and improved healing in second-degree burn wounds compared to standard silver sulfadiazine treatment at three weeks.
April 2023 in “Egyptian journal of Immunology” This study found that human platelet lysate supported mesenchymal stem cell growth as effectively as fetal bovine serum, while fetal bovine serum was more effective for hepatocyte proliferation.
3 citations
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January 2017 in “Stem Cells International” This article highlights the significant challenge that tissue regeneration presents to modern medicine, emphasizing its importance in improving quality of life.
March 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed a new method called Enriched-GF, which enhances growth factor recovery from platelet concentrates through a combination of glass bead activation, freeze-thaw cycling, and calcium stimulation, outperforming conventional methods by providing higher and more consistent yields for regenerative medicine applications.
March 2026 in “International Journal of Molecular Sciences” PRP therapy's success varies and depends on PRP quality and patient condition, with athletes benefiting more.
102 citations
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April 2014 in “PloS one” In this study, Wharton’s Jelly Mesenchymal Stem Cells, cultured with human platelet lysate, showed enhanced wound-healing capabilities and multilineage differentiation potential, distinguishing them from bone marrow-derived stem cells and presenting exciting prospects for regenerative medicine.
16 citations
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December 2019 in “Journal of Cellular and Molecular Medicine” This study found that sonicated platelet-rich plasma was more effective than calcium chloride-induced platelet-rich plasma in activating hair follicle stem cells and promoting hair follicle regeneration in mice.
November 2021 in “International Journal for Research in Applied Science and Engineering Technology” This review discusses the various applications of lyophilized platelet-rich plasma in treating different diseases and reports no new clinical results.
January 2025 in “International Research Journal of Innovations in Engineering and Technology” This review discusses the biological mechanisms, preparation techniques, and clinical applications of platelet-rich plasma therapy, highlighting its variable outcomes and potential improvements for efficacy and standardization; it reports no new clinical results.
79 citations
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October 2015 in “Journal of Dermatological Treatment” This review assesses the use of platelet-rich plasma in dermatology and concludes that while there may be modest benefits for certain conditions, more evidence is needed before it can be widely recommended.
39 citations
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March 2019 in “Dermatologic Surgery” This study's meta-analysis reported that PRP injections significantly increased hair density compared to baseline and placebo in androgenetic alopecia patients, supporting its use as a beneficial treatment.
29 citations
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September 2020 in “International Journal of Molecular Sciences” This review outlines the current state of freeze-dried platelet-rich plasma (FD-PRP) research, emphasizing its use in wound healing, lumbar fusion, knee conditions, and dentistry, but reports no new clinical findings.
25 citations
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January 2018 in “Acta Clinica Croatica” This study found that allogeneic platelet gel significantly improved healing in non-healing chronic lower leg ulcers compared to hydrogel treatment.
22 citations
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January 2015 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This review discusses the increased use of platelet-rich plasma in dermatology for conditions like skin ulcers and alopecia but reports no new clinical results, emphasizing the need for more scientific evidence to support its benefits.
14 citations
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July 2021 in “Biomedicines” This review discusses the roles of platelets in hemostasis and wound repair, the preparation methods for platelet concentrates, and their therapeutic applications in medicine and dentistry, reporting no new clinical results.
12 citations
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April 2015 in “InTech eBooks” Platelet Rich Plasma (PRP) shows promise for tissue repair and immune response, but more research is needed to fully understand it and optimize its use.
9 citations
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June 2020 in “Tissue Engineering and Regenerative Medicine” This study found that applying HHORSC exosomes may enhance the hair inductivity of dermal papilla cells, potentially improving treatments for hair loss.
3 citations
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May 2023 in “Current Molecular Medicine” This review discusses the distinction between platelet-rich plasma and stem cell-based therapies in regenerative medicine, highlighting their different roles and stressing the importance of honest representation by commercial and health entities.
3 citations
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March 2023 in “National Journal of Health Sciences” This article reviews the potential of platelet-rich plasma therapy in managing diabetic foot ulcers but reports no new clinical findings, highlighting the need for further controlled trials to evaluate its effectiveness.