This study found that selective deletion of PIKFyve kinase using a PF4 promoter in mice led to defective platelet lysosome biogenesis and a prothrombotic effect, with unexpected macrophage infiltration in multiple organs.
May 2024 in “International journal of medicine and psychology.” This study found that elderly patients with acute coronary syndrome had higher PRU rates, and ticagrelor showed greater antiplatelet efficacy compared to clopidogrel in this population.
1 citations
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October 2025 in “Transfusion Medicine and Hemotherapy” This review synthesizes current evidence on platelet-rich plasma for dry eye disease and reports no new results; the authors emphasize the need for standardized trials to validate these approaches.
69 citations
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October 2014 in “Stem Cells” This study found that PDGF-D acts as a potent mitogenic factor in adipose-derived stem cells, enhancing their proliferation, migration, and growth factor expression, suggesting its use as a preconditioning agent for ASC transplantation.
42 citations
,
February 2021 in “Signal Transduction and Targeted Therapy” This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.
355 citations
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August 2013 in “Acta Biomaterialia” This study found that a nanoparticle-in-nanofiber system significantly accelerated wound healing in rats by promoting angiogenesis and tissue regeneration more effectively than a commercial wound dressing.
In this narrative review, the authors explored various rehabilitative techniques, including injections and physical therapies, that may enhance aesthetics and psychosocial wellbeing in patients with disabilities, emphasizing a multidisciplinary approach to improve both functional and cosmetic outcomes.
January 2006 in “Basic & Clinical Medicine” In this study, injection of hair keratin artificial material into rats did not significantly affect leucocytes or blood plates compared to normal saline, suggesting its histocompatibility.
102 citations
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August 2008 in “Genes & Development” This study found that laminin-511 is crucial for hair morphogenesis in mice, as it influences primary cilia formation and dermal papilla maintenance through noggin and sonic hedgehog signaling.
5 citations
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February 2022 in “International Journal of Molecular Sciences” This review discusses the roles of distinct immune cell types in skin wound healing, highlighting findings from animal studies, but provides no new clinical results.
January 2024 in “Pharmacy information” New treatments using stem cells and other methods show promise for promoting hair growth in androgenetic alopecia.
January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
488 citations
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July 2021 in “Cell” This review discusses the development, lineages, functions, and roles of fibroblasts in fibrosis across four organs, highlighting their capabilities in tissue repair and contributions to fibrotic disorders when aberrantly activated, but it reports no new experimental findings.
June 2026 in “International Science Journal” This study reviewed recent advances in regenerative technologies for aesthetic and reconstructive medicine and found that adipose-derived stem cells and platelet-rich plasma are well-established for tissue repair due to their safety and effectiveness, while emerging technologies like exosome-based therapies hold future potential.
55 citations
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December 2006 in “Journal of The American Academy of Dermatology” This review discusses the potential for SSRIs to cause serious skin reactions and suggests considering alternative antidepressants if such reactions occur.
January 2009 in “Side effects of drugs annual” This chapter reviews drugs affecting blood coagulation and details the increased hemorrhage risk associated with warfarin interactions, liver disease, heart failure, and antiphospholipid antibodies but reports no new clinical results.
This review discusses various Complementary and Alternative Medicine methods for hair care, such as herbal remedies and hair regeneration techniques, but reports no new clinical findings.
1160 citations
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November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
7 citations
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August 2024 in “Journal of Functional Biomaterials” This review concludes that platelet-rich plasma injections significantly improve knee joint function compared to alternative treatments in managing knee osteoarthritis.
2 citations
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September 2022 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This article discusses the sensitive skin condition of the scalp, its clinical manifestations, triggers, and individualized treatment options, but reports no new clinical results.
December 2025 in “Progress in Biomedical Engineering” This article reviews emerging mechanobiological strategies like electrical stimulation and microneedling combined with nanotechnology as non-invasive methods for hair loss treatment, suggesting these approaches could provide futuristic alternatives to current therapies such as minoxidil, finasteride, and hair transplants.
12 citations
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March 2023 in “The FASEB Journal” This study found that platelet-rich plasma treatment significantly improved erectile function and restored neural structures in aged rats with erectile dysfunction, suggesting potential benefits for geriatric patients.
May 2022 in “International Journal of Clinical Trials” This study concluded that platelet rich fibrin (PRF) may enhance healing and functional recovery compared to platelet rich plasma (PRP) during immediate post-extractive dental implant procedures.
15 citations
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July 2020 in “Applied Sciences” This study found that a single injection of Platelet Rich Stroma improved knee function and reduced pain and stiffness in patients with knee osteoarthritis over twelve months.
14 citations
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May 2022 in “International Journal of Molecular Sciences” This study found that platelet-rich plasma therapy reduced inflammation and improved bladder function in a rat model of ketamine-induced ulcerative cystitis.
3 citations
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March 2024 in “Cureus” This study found that PRP may effectively reduce TMJ pain and improve jaw function and quality of life in young adults with mild TMD.
2 citations
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April 2021 in “The Egyptian Journal of Histology” This study found that platelet-rich plasma may protect and restore ovarian tissues and functions in female rats with ovarian failure induced by cyclophosphamide.
This study found that platelet-rich plasma might support brain health by enhancing glial cell function and modulating immune responses in inflammation, indicating potential as a treatment for brain disorders.
34 citations
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January 2022 in “Human Reproduction Open” This study found no clinically significant effects of intraovarian injection of platelet-rich plasma on ovarian function over one year in patients with extremely low functional ovarian reserve.
6 citations
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August 2025 in “Frontiers in Bioengineering and Biotechnology” This review discusses the evolution of platelet concentrates in regenerative medicine, highlighting a proposed function-driven classification that distinguishes three generations of PCs by biological activity rather than development order, with third-generation exosome-based therapies showing superior therapeutic efficacy over earlier formulations.