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This study found that applying HHORSC exosomes may enhance the hair inductivity of dermal papilla cells, potentially improving treatments for hair loss.

This study reports that adipose mesenchymal stem cell-derived exosomes and platelet-rich plasma both improved the condition of photoaged facial skin, with no significant difference in effectiveness between the two treatments, potentially offering a quicker and less invasive option for patients.

This study found that exosomes derived from platelet-rich plasma show preclinical promise for wound healing but lack sufficient data for other dermatological uses like hair growth and skin rejuvenation.

This study found that exosomes derived from human adipose stem cells significantly enhanced the proliferation and migration of dermal papilla cells compared to those from platelet-rich plasma, suggesting potential benefits for hair loss treatment.

This review explores the evidence for platelet-rich plasma, exosomes, and other regenerative therapies as adjuncts in hair transplantation, finding that PRP has the most support, but highlights the need for standardization and transplantation-specific studies.

This review discusses the potential of platelet-rich plasma and exosome-based therapies for treating various types of alopecia, highlighting their promise but noting the need for more research on standardization and efficacy.

This review explores the basic science and therapeutic potential of stem cells, platelet-rich plasma, and exosomes in regenerative medicine, highlighting their promising roles in skin regeneration and repair but noting a need for further research.

This study found that exosome therapy led to significantly better hair regrowth and patient satisfaction than platelet-rich plasma in men with androgenetic alopecia.

This study critically reviewed recent evidence (2020–2025) on treatments like platelet-rich plasma, photobiomodulation, stem cells, and exosomes for androgenetic alopecia, finding emerging but limited efficacy data and emphasizing the need for standardized protocols to enhance transparency and patient safety.

In this study, researchers observed that platelet-rich plasma-derived exosomes significantly promoted hair regeneration in a murine model of alopecia by enhancing hair follicle stem cell activities and modulating the SIRT1/FoxO3a pathway, suggesting potential clinical benefits for alopecia treatment.

This review found that exosome therapy shows the most promise for hair regrowth and safety in treating androgenetic alopecia, surpassing platelet-rich plasma, while minoxidil remains less effective but more accessible. Further research is needed to refine these treatments.

This review critically assesses recent evidence (2020-2025) on the effectiveness of regenerative therapies like platelet-rich plasma, photobiomodulation, stem cells, and exosomes for treating androgenetic alopecia, highlighting the challenges physicians face due to commercialization and the evolving regulatory landscape.

In this experimental study on alopecia mice, PRP-exosome treatment was reported to significantly improve hair follicle density and the anagen:telogen ratio compared to 5% minoxidil.

In this study, PRP-derived exosomes significantly outperformed minoxidil in promoting hair regeneration in a murine model of androgenetic alopecia, with the combination of both treatments showing enhanced follicular regeneration and increased markers of tissue proliferation and Wnt signaling pathway activity.

This study found that PRP-Exos may stimulate hair follicle growth and enhance regeneration in cases of AGA by activating the Wnt/β-Catenin signaling pathway, showing potential both in vitro and in vivo.

This study found that in a testosterone-induced androgenetic alopecia mouse model, the combination of PRP-derived small extracellular vesicles and 5% minoxidil significantly improved hair follicle density and the anagen-to-telogen ratio compared to minoxidil alone, suggesting a synergistic effect that enhances hair growth.

This paper highlights the growing interest in exosomes for their therapeutic and diagnostic potential in cosmetic dermatology, noting their roles in skin rejuvenation, postprocedural care, and antiaging treatments.

This study found that garlic exosomes induced hair growth in rats by increasing anagen follicle counts and activating multiple signaling pathways, including Wnt-1, β-catenin, and TGF-β1.

This review discusses the evolution of platelet concentrates in regenerative medicine, highlighting a proposed function-driven classification that distinguishes three generations of PCs by biological activity rather than development order, with third-generation exosome-based therapies showing superior therapeutic efficacy over earlier formulations.

This systematic review found that exosome-based therapies significantly improve skin elasticity, reduce wrinkle depth, enhance hydration, and modulate pigmentation, with minimal adverse events reported across multiple studies. However, further clinical trials are necessary to confirm long-term efficacy and safety.

This review highlights exosomes as a promising treatment for skin damage from UV light, infrared radiation, burns, and disorders due to their anti-inflammatory properties, ability to induce macrophage polarization, and acceleration of skin repair and regeneration.

This review examines how regenerative therapies targeting shared biological pathways can promote healing in musculoskeletal disorders and hair follicle dysfunction, highlighting modalities like platelet-rich plasma and laser therapy while addressing challenges in standardization and measurement.

This study reviews international perspectives on using platelet-rich plasma, stem cells, and exosomes, highlighting their expanding applications in fields like oncology, dermatology, neurology, and rheumatology, with an emphasis on ethical considerations and the need for further research.

CGF-PF may improve hair loss treatment by targeting hair follicle stem cells more effectively.

This study found that salmon tissue-derived exosomes showed significantly greater improvements in hair density and other parameters compared to platelet-rich plasma in patients with mild to moderate androgenetic alopecia.

This study found that in a fluconazole-induced alopecia-like rat model, a 14-day treatment with hypoxia-induced mesenchymal stem cell exosomes significantly increased TGF-β and PDGF levels, which may improve hair growth and suggests a potential therapeutic strategy for alopecia and other inflammation-related skin disorders.

Exosomes and stem-cell therapies slightly outperform PRP in improving hair and skin, but more research is needed.

Exosomes and stem-cell therapies slightly outperform PRP in improving hair and skin, but more research is needed.

This study bibliometrically evaluated 5741 articles on PRP from 1980 to 2024, highlighting Türkiye's contribution and identifying prominent research areas such as orthopedics and wound healing.