Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this clinical study, melatonin treatment reduced oxidative stress markers and enhanced hair growth in patients with alopecia areata, potentially through its effects on the immune system and antioxidant activity.

In this animal study, the researchers found that administering anionic lipid nanoemulsions called squarticles increased survival rates and mitigated the adverse effects of amitriptyline overdose in rats.

In this study, finasteride significantly reduced plasma cholesterol and triglycerides and decreased atherosclerotic lesion burden in mice, suggesting its potential role in delaying cardiovascular disease.

This study found that Hibiscus rosa-sinensis dried leaves extract displayed the strongest pancreatic lipase inhibitory activity among 37 tested plant extracts, showing potential as an anti-obesity agent with effects comparable to the pharmaceutical drug orlistat in reducing plasma triacylglycerol levels in rats.

This study found that enzyme replacement therapy in mice with a severe form of classical homocystinuria improved metabolic patterns and alleviated many clinical symptoms.

This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.

This study suggests revising PCOS diagnostic criteria to integrate the polymenorrhoea subcategory due to shared metabolic dysfunctions with oligomenorrhoea.

This article summarizes discussions from a minisymposium on organelle contact sites, highlighting new insights into their roles in cellular processes, but reports no novel experimental results.

This study on male rats found that finasteride treatment led to the differential expression of several genes in the hypothalamus and hippocampus, hinting at potential links to observed side effects like depression, anxiety, and cognitive disturbances.

This systematic review reported that PCOS is marked by increased androgens, hirsutism, and an elevated LH/FSH ratio, with metformin showing a therapeutic effect on menstrual cycles, emphasizing the need for individualized treatment strategies.

This study observed that women with PCOS had significant differences in body composition and some physiological markers compared to healthy women, which may have implications for pregnancy outcomes and long-term health risks.

This study discusses how testosterone exerts its effects directly or through conversion to metabolites, DHT and estradiol 17β, each influencing different physiological processes, noting that DHT conversion is necessary for certain effects but not for muscle, bone, or erythropoiesis impacts.

This article examines the role and composition of integral hair lipids in forming a protective barrier similar to the skin's epidermal lipid layer and reports no new findings about their effects.

This review examines the advances in nanostructured lipid carriers for treating hyperpigmentation but presents no new clinical results; the authors highlight their potential benefits and applications.

This document extends previous recommendations by the National Lipid Association for managing dyslipidemia, focusing on lifestyle therapies, special patient groups, and strategies to enhance adherence and patient outcomes.

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.

This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.

In this study, disruptions in phospholipase A2 activity in Arabidopsis thaliana significantly impaired the plasma membrane localization of PIN proteins, affecting auxin transport and root development.

This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.

This study identified trilauric glyceride and decanoylcarnitine as potential biomarkers for diagnosing PCOS in patients with and without insulin resistance, suggesting significant metabolic alterations in these conditions.

This study developed lipid nanoparticles for delivering minoxidil and finasteride to the dermis and hair follicles, showing stability and a desired prolonged release, though with low skin penetration levels.

This study found that Runx1 in hair follicle stem cells modulates lipid metabolism, impacting membrane organization and enhancing signal transduction for cell proliferation in both normal and cancer epithelial cells.

This study found that nano-sized lipid particles improved the skin accumulation and retention of dexamethasone compared to a base cream, suggesting potential benefits for inflammatory skin disease treatment.

This study found that nanostructured lipid carriers provided better skin-targeted delivery and drug loading for lidocaine than nanoethosomes, indicating improved local anesthetic efficacy in vitro.

This study found that mice lacking myelin protein zero-like 3 (Mpzl3) had reduced body weight and adiposity despite increased food intake, which was linked to higher energy expenditure and improved glycemic control.

This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.

In a double-blind clinical trial, this study found that a gel containing chitosan-coated spironolactone nanoparticles effectively reduced acne lesions over 8 weeks without adverse skin effects, suggesting potential for enhanced acne treatment through targeted skin delivery.

This study found that using nanoporous silica entrapped lipid-drug complexes enhanced the solubility and bioavailability of dutasteride in beagle dogs.

This study involving male patients with androgenic alopecia found that a higher baseline zinc plasma level, specifically above 10 µmol/L, may predict the success of treatment with 5% topical minoxidil, correlating with increased hair density and diameter in the parietal area.

This study found that plasma jets can effectively clean and oxidize human hair fibers, with argon/oxygen plasma having the strongest effects, suggesting potential as an alternative to peroxide treatment.