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Si Jun Zi Tang may slow aging by affecting specific cell signaling pathways.

Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

Eosinophilia-myalgia syndrome, linked to contaminated L-tryptophan supplements, caused severe symptoms and some deaths, with long-term effects in survivors.

Finasteride may affect PNMT, causing side effects.

People with polycystic ovary syndrome are more likely to have poor sleep, restless legs syndrome, anxiety, and depression.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Post-finasteride Syndrome causes lasting negative effects, but more research is needed for treatment and risk evaluation.

Animal research has greatly advanced dermatology.

Keratin 18 helps diagnose and predict cancer progression and affects cancer growth and spread.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Acne can appear or persist in adulthood due to hormonal changes, external factors, or substance use, and requires appropriate treatment.

Pubertal acne is linked to hormonal changes, affects quality of life, and is treated similarly to adult acne.

People with advanced chronic kidney disease often have skin problems, which can be treated with various medications and procedures to improve their quality of life.

Early signs of PCOS in girls, like irregular periods and polycystic ovaries, suggest a need for early diagnosis and intervention to prevent further health issues.

Some cosmetics and dermatological drugs can cause allergic reactions and side effects, like skin irritation and systemic issues.

Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.