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    Glossary Plakophilin-1

    protein crucial for cell adhesion in skin and hair

    Plakophilin-1 (PKP1) is a protein that plays a crucial role in the formation and maintenance of desmosomes, which are structures that help cells stick together, particularly in tissues that experience a lot of stress, like the skin and heart. Mutations in the gene encoding Plakophilin-1 can lead to skin disorders and hair loss conditions, such as ectodermal dysplasia/skin fragility syndrome, highlighting its importance in maintaining the integrity of epithelial tissues.

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    Research 30 of 86

    1. Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs PLoS ONE · 2012 · 28 citations
    2. Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases 2026
    3. Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis 2012 · 47 citations
    4. Animal models of human skin disease Experimental Dermatology · 2004 · 4 citations
    5. Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins Acta Histochemica · 2013 · 12 citations
    6. Intercellular junctions in normal epidermis Experimental Dermatology · 2004 · 2 citations
    7. Decision letter: Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness 2022
    8. Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome The American Journal of Dermatopathology · 2005 · 31 citations
    9. Inherited Disorders of the Hair Elsevier eBooks · 2013 · 2 citations
    10. Alopecia in Epidermolysis Bullosa Dermatologic Clinics · 2009 · 21 citations
    11. Hair Loss in Autoimmune Cutaneous Bullous Disorders Dermatologic Clinics · 2011 · 12 citations
    12. Dermatopathology and molecular genetics Journal of The American Academy of Dermatology · 2008 · 12 citations
    13. Beyond Expectations International review of cell and molecular biology · 2014 · 70 citations
    14. Epithelial–mesenchymal transition in cutaneous fibrosis disease: from mechanisms to therapy Frontiers in Immunology · 2026
    15. Case Report: Bi-allelic missense variant in the desmocollin 3 gene causes hypotrichosis and recurrent skin vesicles Frontiers in genetics · 2022
    16. An Investigation of Hair and its Keratin Associated Proteins using Advanced Light Microscopy Durham e-Theses (Durham University) · 2019
    17. Towards a molecular understanding of hair loss and its treatment Trends in Molecular Medicine · 2001 · 236 citations
    18. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010 · 89 citations
    19. Mechanical forces in skin disorders Journal of Dermatological Science · 2018 · 65 citations
    20. Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update Journal of Dermatological Science · 2012 · 52 citations
    21. To grow or not to grow: Hair morphogenesis and human genetic hair disorders Seminars in Cell & Developmental Biology · 2013 · 43 citations
    22. Congenital hair loss disorders: Rare, but not too rare The Journal of Dermatology · 2011 · 41 citations
    23. The Genetics of Human Skin Disease Cold Spring Harbor Perspectives in Medicine · 2014 · 24 citations
    24. Unraveling the Molecular Mechanisms of Hair and Nail Genodermatoses Archives of Dermatology · 2001 · 23 citations
    25. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    26. Differential proteomics of lesional vs. non-lesional biopsies revealed non-immune mechanisms of alopecia areata Scientific Reports · 2018 · 19 citations
    27. Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function Cell Death and Disease · 2015 · 17 citations
    28. Genetics of Structural Hair Disorders Journal of Investigative Dermatology · 2012 · 17 citations
    29. Molecular Genetics of Alopecias Current problems in dermatology · 2015 · 9 citations
    30. 1310 Anti-aging effects of retinoid hydroxypinacolone retinoate on skin models Journal of Investigative Dermatology · 2018 · 4 citations