50 citations
,
July 2014 in “International Journal of Clinical Pharmacology and Therapeutics” This study found that both topical and oral finasteride significantly reduced plasma DHT after one week, with lower finasteride plasma exposure for the topical formulation.
50 citations
,
July 1996 in “Fertility and Sterility” This study found that finasteride significantly reduced hirsutism scores in women with idiopathic hirsutism and PCOS, despite no changes in serum androgen levels.
49 citations
,
March 2019 in “Journal of Investigative Dermatology” This review discusses dermal white adipose tissue's roles in skin immunity, highlighting its antimicrobial function and interactions with other immune cells, but reports no new clinical results.
49 citations
,
July 2004 in “Anesthesiology” This review discusses pharmacologic treatment options for muscle-related pain conditions and notes that there is strong evidence for the efficacy of tricyclic antidepressants and muscle relaxants in specific myofascial pain syndromes, but not universally.
48 citations
,
May 2023 in “Nature Communications” In a study on muscle regeneration in mice, researchers found that platelet-secreted CXCL7 is crucial for recruiting neutrophils to injury sites, aiding early muscle repair and optimal regrowth, suggesting potential therapeutic uses for boosting muscle healing.
48 citations
,
January 2017 in “Skin Pharmacology and Physiology” This study found that polymeric nanoparticles may effectively deliver finasteride topically to hair follicles, potentially improving alopecia treatment with fewer side effects than oral forms.
48 citations
,
September 2013 in “Oncologist” This study reported that alopecia is a common but often underreported side effect of endocrine-based cancer therapies, with tamoxifen showing the highest incidence of hair loss among analyzed treatments.
48 citations
,
April 2013 in “Expert Opinion on Investigational Drugs” This article reviews emerging treatments for androgenetic alopecia, including topical 5-alpha-reductase inhibitors and prostaglandin modulators, but reports no clinical results and calls for further efficacy evidence, especially for PRP.
47 citations
,
February 2021 in “Pharmacological research” This review discusses the potential of endogenic and exogenous exosomes in dermatology and cutaneous aesthetics, highlighting their capacity to repair and rejuvenate skin tissue, but reports no new experimental results.
47 citations
,
September 2015 in “Journal of Drug Delivery Science and Technology” This article reviews various strategies, primarily developed by the Turin University Pharmaceutical Technology group, for increasing entrapment efficiency of hydrophilic molecules in nanoparticulate systems and reports no clinical results.
47 citations
,
January 2015 in “Dermatology” This review revisits mechanisms underlying acne lesion formation and suggests that preventing comedone development requires controlling critical factors in the pilosebaceous follicle before acne involvement.
47 citations
,
November 2012 in “Expert Opinion on Therapeutic Patents” The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
46 citations
,
August 2019 in “Journal of Ethnopharmacology” This review compiles current information about Eclipta prostrata, traditional uses, and its promising pharmacological properties, like hepatoprotective and anti-inflammatory effects, but emphasizes that more research is needed to fully understand its mechanisms and ensure safety for clinical application.
45 citations
,
June 2016 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This review evaluates the scientific literature on silicon supplements, noting that orthosilicic acid shows higher bioavailability, but emphasizes the need for further clinical studies on safety and efficacy.
45 citations
,
January 2008 in “Drugs” This study found that dutasteride effectively improved urinary symptoms, reduced acute urinary retention risk, and decreased prostate volume in men with moderate to severe BPH over two years.
44 citations
,
August 2010 in “Lupus” This article reviews the characteristics and classification criteria of cutaneous lupus erythematosus and reports no new clinical findings.
44 citations
,
March 1987 in “Journal of The American Academy of Dermatology” This study found that both 2% and 3% topical minoxidil were more effective than placebo in promoting hair growth for men with male pattern baldness over 12 months.
43 citations
,
June 2016 in “Clinics in Plastic Surgery” This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.
43 citations
,
February 2013 in “Developmental dynamics” This study found that Eda and activin A regulate Foxi3 expression, which may contribute to the development of hypohidrotic ectodermal dysplasia by affecting Foxi3 activity in ectodermal appendages like hair and teeth.
43 citations
,
November 2007 in “Dermatologic Clinics” This article discusses various hair and nail abnormalities linked to paraneoplastic conditions and cancer treatments, emphasizing their potential role in diagnosing and managing internal malignancies and reports no new clinical findings.
42 citations
,
February 2021 in “Signal Transduction and Targeted Therapy” This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.
42 citations
,
November 2018 in “Archives of dermatological research” Apremilast was not effective in treating moderate-to-severe alopecia areata.
42 citations
,
January 1998 in “BioDrugs” Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.
41 citations
,
August 2024 in “Drug Delivery and Translational Research” This review discusses the development and applications of microneedles, particularly through 3D printing, highlighting their potential in transdermal drug delivery but reporting no new results.
41 citations
,
January 2014 in “Annals of Dermatology” This study found that dermoscopy showed distinctive patterns for different types of alopecia, supporting its clinical usefulness for diagnosing diseases with small round or oval hairless patches on the scalp.
41 citations
,
December 2008 in “Journal of the American Academy of Dermatology” This review discusses fixed drug eruption (FDE) potentially linked to finasteride and emphasizes dermatologists' need to recognize its possible occurrence due to the drug's widespread use, but reports no new clinical results.
41 citations
,
October 2008 in “The American journal of pathology” This study found that reducing BMP signaling in mouse nipple epithelia, achieved through Noggin overexpression, can convert them into hairy skin with pilosebaceous units.
40 citations
,
August 2018 in “Skin appendage disorders” This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.
40 citations
,
March 2018 in “Aesthetic Surgery Journal” This study found that a single injection of platelet-rich stroma significantly increased hair density in men with androgenetic alopecia within 6 to 12 weeks, with no reported side effects.
40 citations
,
January 2009 in “Skin Pharmacology and Physiology” This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.