26 citations
,
February 2012 in “Journal of Investigative Dermatology” This study found that dermal papilla cells from human hair follicles can be reprogrammed into induced pluripotent stem cells, but their efficiency is similar to that of fibroblasts, unlike in mice.
26 citations
,
January 1982 in “Hormone Research” This study found that plasma androgen levels tend to be lower than normal in patients with multiple pituitary hormone deficiencies, particularly those with ACTH deficiencies, and that human growth hormone treatment does not affect adrenal androgen secretion.
25 citations
,
February 2024 in “Biomaterials” In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.
25 citations
,
May 2020 in “Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine” This article discusses the potential benefits of platelet-rich plasma injections in ovarian tissue to improve reproductive outcomes in IVF for older individuals and proposes a mechanism to enhance embryo ploidy rescue, but reports no new clinical results.
25 citations
,
September 2019 in “PubMed” This review discusses the therapeutic potential of platelet-rich plasma in dermatology and highlights the need for standardized treatment protocols, but reports no new clinical results.
25 citations
,
April 2018 in “Journal of Cosmetic Dermatology” This study found that platelet-rich plasma injections improved hair density and diameter in women with androgenetic alopecia not responding to other treatments over 24 weeks, with no adverse events reported.
25 citations
,
January 2018 in “Acta Clinica Croatica” This study found that allogeneic platelet gel significantly improved healing in non-healing chronic lower leg ulcers compared to hydrogel treatment.
25 citations
,
November 2017 in “Molecular Medicine Reports” This study found that PlncRNA‑1 may enhance the proliferation and differentiation of hair follicle stem cells by upregulating the TGF‑β1-mediated Wnt/β-catenin signaling pathway.
25 citations
,
July 2017 in “Journal of Stomatology, Oral and Maxillofacial Surgery” This review suggests that PRP injections may be effective in promoting hair regrowth, reducing hair loss, and increasing hair thickness in patients with androgenic alopecia.
25 citations
,
March 2017 in “Journal of Dermatological Treatment” This review found that the current evidence on using platelet rich plasma to treat non-cicatricial alopecia, such as androgenetic alopecia and alopecia areata, is of low quality and yields controversial results.
25 citations
,
August 2016 in “Journal of Cosmetic Dermatology” This study found that a marine complex supplement significantly reduced hair shedding and increased hair growth in men with thinning hair over 180 days.
25 citations
,
May 2014 in “Facial Plastic Surgery” In this study, intradermal injections of autologous platelet-rich fibrin matrix significantly increased hair density in patients with androgenetic alopecia at 2 and 3 months after initial treatment.
25 citations
,
December 1974 in “Clinical Pharmacology & Therapeutics” Propranolol affects heart rate and renin levels in minoxidil-treated patients.
24 citations
,
November 2023 in “International Journal of Molecular Sciences” This review highlights that platelet-rich plasma and adipose-derived stem cell therapy may offer safe and promising improvements for managing symptoms of genital lichen sclerosus, with a potential synergistic benefit when combined.
24 citations
,
January 2021 in “Dermatologic Therapy” This review found that platelet-rich plasma therapy improved hair growth and thickness in most studies on alopecia, with the highest improvement seen when combined with Minoxidil.
24 citations
,
November 2019 in “Dermatologic Surgery” This review evaluates the use of platelet-rich plasma in dermatology, highlighting favorable outcomes in several areas, especially androgenetic alopecia, despite a lack of large randomized controlled trials and consistency in protocols.
24 citations
,
January 2019 in “Journal of Cosmetic Dermatology” In this study, the authors reported that among patients with androgenetic alopecia, treatment with minoxidil 5% lotion combined with PRP and microneedling resulted in better hair growth and higher satisfaction compared to other treatment groups.
24 citations
,
January 2018 in “Development” This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.
24 citations
,
November 2017 in “Aesthetic Plastic Surgery” In this study, researchers found that homologous PRP (h-PRP) significantly increased hair density more than both nonactivated (n-PRP) and activated (a-PRP) autologous PRP in patients with androgenetic alopecia, suggesting h-PRP as a potentially more effective treatment option for hair loss.
24 citations
,
June 2016 in “Acta dermato-venereologica” In this case report, tofacitinib was associated with new hair growth on psoriasis lesions after three months of treatment.
23 citations
,
November 2017 in “Stem cell investigation” This study found that platelet lysate produced higher follicular regeneration in hair restoration surgeries compared to activated PRP and saline, with significant gains in both follicular unit and hair density.
23 citations
,
December 2021 in “International Journal of Environmental Research and Public Health” This study found that advanced platelet-rich fibrin (A-PRF) reduced postoperative complications like pain, trismus, and edema following mandibular wisdom teeth removal.
23 citations
,
September 2020 in “Journal of Cosmetic Dermatology” This review discusses the potential applications of injectable platelet‐rich fibrin in various conditions and reports no new clinical results; the authors highlight its favorable use in comparison to existing treatments.
23 citations
,
June 2018 in “Facial Plastic Surgery” This review suggests that platelet-rich plasma is a low-risk treatment for androgenic alopecia with good patient satisfaction and positive objective outcomes, but further research is needed to refine methods and standardize outcome measurements.
23 citations
,
May 2005 in “British Journal of Cancer” This study reported the feasibility of detecting six cell-cycle-related nuclear markers in plucked human scalp and eyebrow hair, providing valuable insights for future intervention studies.
23 citations
,
January 2003 in “Journal of Pediatric Endocrinology and Metabolism” This study observed that the use of hormonal hair products remains common among US Army School personnel, with higher use rates among non-white, female, and enlisted individuals.
22 citations
,
November 2024 in “Planta” This review highlights the potential of aromatic plants as natural antioxidants in cosmeceuticals, which may combat skin aging and promote rejuvenation by counteracting oxidative stress, offering a natural alternative to synthetic products with benefits like photoprotection and anti-wrinkle effects.
22 citations
,
October 2024 in “Advanced Healthcare Materials” This study demonstrated that gelatine-based hydrogel foams loaded with platelet extracellular vesicles (pEVs) promoted full wound closure in a chronic wound rat model within 14 days, suggesting potential for personalized treatment of chronic diabetic wounds.
22 citations
,
October 2019 in “Dermatologic Surgery” This study found that platelet-rich plasma was effective for hair regrowth in women with androgenic alopecia, though less so than minoxidil, but it was associated with improved quality of life responses.
22 citations
,
October 2018 in “Aesthetic Plastic Surgery” This review discusses the latest understanding of androgenetic alopecia, including stem cell niches in hair follicles, and highlights emerging treatments like growth factors and platelet-rich plasma without new clinical findings.