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Glossary Piroctone Olamine

antifungal agent used to treat dandruff and scalp conditions

Piroctone Olamine is an antifungal agent commonly used in shampoos and other hair care products to treat dandruff and seborrheic dermatitis. It works by inhibiting the growth of the yeast Malassezia, which is often responsible for these scalp conditions. This compound is favored for its effectiveness and lower irritation potential compared to other antifungal agents like zinc pyrithione.

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Nudging Hair Shedding by Antidandruff Shampoos: A Comparison of 1% Ketoconazole, 1% Piroctone Olamine, and 1% Zinc Pyrithione Formulations

research Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations

43 citations , October 2002 in “International Journal of Cosmetic Science”

This study found that 1% ketoconazole and 1% piroctone olamine shampoos increased hair shaft thickness and reduced hair shedding in men with telogen effluvium and androgenic alopecia associated with dandruff.

research Antidandruff hair tonic containing piroctone olamine

4 citations , January 1988 in “Cosmetics and toiletries”

0.1% piroctone olamine in hair tonics effectively treats dandruff.

Scalp Application of the Antioxidant Piroctone Olamine Reduces Hair Shedding in an 8-Week Randomized, Double-Blind, Placebo-Controlled Clinical Study

research Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8‐week randomized, double‐blind, placebo‐controlled clinical study

1 citations , August 2021 in “International journal of cosmetic science (Print)”

This study reported that using piroctone olamine in either a shampoo or leave-on product form significantly increased hair retention and improved scalp condition in women with perceived hair thinning.

research 75202 Evaluation of the anti-dandruff and soothing effect of a hair conditioner containing 0.4% piroctone olamine and niacinamide

July 2026 in “Journal of the American Academy of Dermatology”

research Improvement in the inflammatory aspect of androgenetic alopecia. A pilot study with an antimicrobial lotion

40 citations , January 1996 in “Journal of Dermatological Treatment”

This study found that using an antimicrobial lotion for 18 months may reduce inflammation and potentially partially reverse hair loss in men with androgenetic alopecia.

research Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24‐week randomized, double‐blind, placebo‐controlled clinical trial

6 citations , August 2021 in “International Journal of Cosmetic Science”

This study concluded that a regimen containing functional antioxidants and barrier-enhancing agents reduced hair shedding and increased perceived hair fullness in participants with self-perceived hair thinning over 24 weeks.

research Clear scalp, clear mind: Examining the beneficial impact of dandruff reduction on physical, emotional and social wellbeing

2 citations , January 2025 in “International Journal of Cosmetic Science”

In this study, dandruff treatment with anti-dandruff shampoos was found to effectively reduce symptoms and enhance emotional wellbeing, indirectly improving daily functioning by alleviating scalp-related emotional distress, though it did not affect self-esteem.

research Highly Efficient Rinse-Off/Leave-On Scalp Care Treatments to Reduce Moderate to Severe Dandruff

2 citations , January 2013 in “Journal of cosmetics, dermatological sciences and applications”

This study found that both an anti-dandruff shampoo containing piroctone olamine and climbazole and its combination with a tonic reduced dandruff and inflammation, with the combination showing superior results.

research Physiological Characteristics of Scalp Skin With High Sebum Production and the Impacts of Shampoo Cleansing

August 2026 in “Skin Research and Technology”

This study observed that among individuals with scalp seborrhoea, the scalp showed higher sebum levels, lower hydration, and compromised barrier function compared to other areas, and that a single shampoo application containing piroctone olamine significantly reduced sebum and oxidative stress markers.

Clinical Evaluation of the Efficacy and Safety of ThriveCo Anti-Dandruff Pre-Shampoo Treatment Containing Zenscalpin in the Management of Scalp Dandruff in Healthy Adults

research Clinical evaluation of the efficacy and safety of ‘ThriveCo anti-dandruff pre-shampoo treatment,’ containing ZenscalpinTM in the management of scalp dandruff in healthy adults

January 2024 in “Journal of Dermatology & Cosmetology”

This study found that the ThriveCo Anti-Dandruff Pre-Shampoo Treatment, containing ZenscalpinTM, significantly reduced dandruff by 54.79% after 8 days and improved scalp health, with most participants reporting reduced flaking, dryness, and itchiness, and no noted adverse events.

research THERAPEUTIC MANAGEMENT OF GENERALIZED CANINE DEMODICOSIS WITH SECONDARY BACTERIAL AND YEAST INFECTIONS-A CASE REPORT

April 2023 in “JIVA : journal of Indian Veterinary Association Kerala/JIVA :Journal of Indian Veterinary Association, Kerala”

This case study reported the successful recovery of a Doberman Pinscher with skin lesions, demodicosis, pyoderma, and malasseziosis following treatment with fluralaner, enrofloxacin, shampoos, immune boosters, and fatty acids.

research Topical lotion beneficial in androgenetic alopecia

November 1996 in “Inpharma Weekly”

Lotion with piroctone olamine and triclosan improves hair loss in men.

research Study of the composition of 140 shampoos: similarities and differences depending on the sales channel used

2 citations , March 2019 in “European Journal of Dermatology”

This study concluded that shampoos sold in pharmacies generally contain fewer regulated allergens under EU law compared to those sold in mass-market stores or by mail order, and pharmacy-sold baby shampoos were allergen-free.

research S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents

151 citations , August 2010 in “British Journal of Dermatology”

This guideline reviews the diagnosis of androgenetic alopecia and offers expert consensus recommendations tailored to males, females, and adolescents, but reports no new clinical results.

research Finasteride

125 citations , January 1999 in “Drugs”

This study found that oral finasteride 1 mg/day promotes hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss over two years.

research Stratum corneum dysfunction in dandruff

93 citations , April 2012 in “International Journal of Cosmetic Science”

This article discusses the role of stratum corneum disruption in dandruff and suggests that treatments improving scalp barrier integrity along with antifungal activity may be beneficial; it reports no new research findings.

research A Comprehensive Pathophysiology of Dandruff and Seborrheic Dermatitis – Towards a More Precise Definition of Scalp Health

89 citations , January 2013 in “Acta dermato-venereologica”

This review examines dandruff and seborrheic dermatitis, highlighting the role of Malassezia yeasts in inflammation and hyper-proliferation, and reports no new clinical findings.

research From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber

81 citations , April 2009 in “Journal of Investigative Dermatology”

This review discusses the shedding phase of the hair cycle, known as exogen, and reports no new findings while analyzing related processes like club fiber formation and release.

research Shampoos: Ingredients, efficacy and adverse effects

67 citations , April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft”

This article reviews the development and formulation of shampoos, emphasizing their dual role as cosmetic and medicinal products, but presents no new experimental findings.

research From Axioms to New Insights into Dandruff

66 citations , January 2000 in “Dermatology”

This review discusses the nature, origin, and treatments of dandruff, with a focus on the role of *Malassezia* spp. and other triggering factors, but reports no new research findings.

research EEMCO Guidance for the Assessment of Hair Shedding and Alopecia

51 citations , January 2004 in “Skin Pharmacology and Physiology”

This review discusses various techniques for evaluating hair shedding and alopecia but reports no new clinical results. The authors emphasize the value of specific clinical and instrumental methods in assessing hair growth.

research Topical ketoconazole: a systematic review of current dermatological applications and future developments

39 citations , January 2019 in “Journal of Dermatological Treatment”

This review found topical ketoconazole to be highly effective against Malassezia-related skin conditions, though other treatments may outperform it for Tinea and Candida infections.

research The Female Pattern Hair Loss: Review of Etiopathogenesis and Diagnosis

35 citations , January 2014 in “BioMed Research International”

This review examines the epidemiology, pathogenesis, clinical manifestations, and diagnosis of female pattern hair loss and reports no new results.

research Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology

22 citations , October 2020 in “Anais Brasileiros de Dermatologia”

This consensus concluded that oral isotretinoin is highly effective for treating acne and some off-label conditions, with common adverse events being manageable and rare serious risks not contraindicating use.

research Shampoos and hair conditioners

21 citations , July 1988 in “Clinics in dermatology”

This article reviews haircare practices and hair cosmetics for patients with alopecia, emphasizing healthy scalp maintenance and caution in styling; it reports no new clinical results.

research Dermoscopy Update: Review of its Extradiagnostic and Expanding Indications and Future Prospects

19 citations , October 2019 in “Dermatology Practical & Conceptual”

This review discusses the expanding applications of dermoscopy in dermatological diagnosis beyond its initial use for detecting dysplastic nevi and reports no new clinical results.

research Treatment of male androgenetic alopecia with topical products containingSerenoa repensextract

18 citations , May 2015 in “Australasian Journal of Dermatology”

This study found that topical application of Serenoa repens extract increased hair count in men with androgenetic alopecia, suggesting it could be an alternative for those unable to use standard medications.

The New Paradigm for Androgenetic Alopecia and Plant-Based Folk Remedies: 5α-Reductase Inhibition, Reversal of Secondary Microinflammation, and Improving Insulin Resistance

research The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance

16 citations , September 2018 in “Journal of Ethnopharmacology”

This review discusses the role of inheritance, androgens, and microinflammation in androgenetic alopecia and suggests some plant-based folk remedies may help address these factors but reports no new clinical results.

research Does tachyphylaxis occur in long‐term management of scalp seborrheic dermatitis with pyrithione zinc‐based treatments?

16 citations , December 2008 in “International Journal of Dermatology”

This study concluded that no evidence of tachyphylaxis was found in the treatment of scalp seborrheic dermatitis and dandruff using pyrithione zinc-based shampoos over a 48-week period.

Roxithromycin Antagonizes Catagen Induction in Murine and Human Hair Follicles: Implication of Topical Roxithromycin as Hair Restoration Reagent

research Roxithromycin antagonizes catagen induction in murine and human hair follicles: implication of topical roxithromycin as hair restoration reagent

15 citations , September 2008 in “Archives of Dermatological Research”

In this study, topical 5% roxithromycin was effective in restoring hair growth in about half of individuals with androgenetic alopecia without causing adverse effects.