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Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Telocytes might help with skin repair and regeneration.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Alopecia areata causes hair loss, has no cure, and various treatments exist.

Stem cell self-renewal is complex and needs more research for full understanding.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Cathepsin L is essential for normal hair growth and development.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

Different types of stem cells and their environments are key to skin repair and maintenance.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.