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Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

The document concludes that correct diagnosis of alopecia types is crucial, scalp biopsies are important, and more research is needed.

Oral isotretinoin for severe acne can change hormone levels but does not significantly affect ovarian function.

ADT-G may be a useful indicator of increased androgen levels in women with acne and can be lowered with certain birth control pills.

Skin problems in PCOS, like excess hair, acne, and hair loss, may not always indicate high male hormone levels and need careful diagnosis for proper treatment.

People with hidradenitis suppurativa often have lower vitamin D levels, weaker hip bones, and altered bone metabolism markers.

Pangolins have lost some skin-related genes, but kept others, showing complex skin evolution.

The document concludes that scalp health is influenced by complex factors affecting sebaceous glands, including hormones, aging, and various substances.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

LED therapy is safe and shows potential for treating skin conditions and promoting hair growth, but more research is needed.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

New alopecia treatments aim for better results and fewer side effects.

Female pattern hair loss has unclear causes, possibly involving genetics, hormones, and environment, and needs better treatments.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Ovarian SAHA syndrome makes women with PCOS more resistant to insulin and increases their risk of blood sugar problems.

PCOS may start before birth, involves metabolic issues, and can be treated with drugs like metformin and lifestyle changes.

The study found that hair follicles are above muscle connections in the scalp, which may help protect stem cell areas.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

Hair in mammals likely evolved from glandular structures, not scales.

Lipid-coated silica nanoparticles penetrate human skin more deeply than bare silica nanoparticles.