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This study found that exercise decreases the expression of 5αR1, thereby enhancing the PI3K/AKT signaling pathway in PCOS rats.

In this study, researchers overexpressed Lrig3 in mouse skin and observed hair loss linked to changes in skin protein profiles and signaling pathways, suggesting a potential role for Lrig3 in maintaining skin homeostasis.

This study found that mammary resident macrophages play a key role in mammary tissue development by influencing cell division and maintaining mammary stem cell activity through the TNF-α-Cdk1/Cyclin B1 signaling pathway, highlighting their importance in the mammary stem cell niche.

This report documents the successful use of theophylline in treating an 11-year-old girl with a rare immunodeficiency syndrome, suggesting potential in drug repurposing for primary immunodeficiency disorders and asthma.

This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.

This review summarizes recent findings on how the dysregulated PI3K/Akt/mTOR pathway contributes to immune-mediated inflammatory skin disorders and discusses the potential of natural products, synthetic compounds, and biologic agents in their treatment. However, it emphasizes the need for further research to develop effective therapies.

This article reviews potential mechanisms by which Finasteride might enhance mesenchymal stem cell viability and differentiation post-transplant, suggesting a supportive role in myocardial infarction therapy, yet reports no clinical results.

This study explored the mechanism of Shaoyao Gancao decoction in treating alopecia areata and found that it may be closely related to the PI3K/AKT signaling pathway.

This study suggests that the key mechanism of stress-related hair loss involves CRH-induced PTEN loss, which reduces autophagy and increases apoptosis in dermal papilla cells, highlighting potential therapeutic targets like PTEN activation or autophagy enhancement.

This study highlights IGF-1's role in promoting hair follicle proliferation, vascularization, and growth, suggesting its potential as a treatment target for hair loss disorders like androgenetic alopecia, though more research on delivery methods and long-term effects is needed.

This study found that an acellular dermal matrix derived from tilapia skin significantly accelerated wound healing and improved tissue regeneration quality in mouse and pig models compared to a commercial porcine-derived matrix, suggesting its potential as a safe, cost-effective bioscaffold for skin repair.

This review reported that tripeptides, such as GHK and KdPT, show promise in enhancing wound healing through multiple mechanisms, including promoting cell migration, collagen deposition, and angiogenesis, while offering antimicrobial and anti-inflammatory benefits for both acute and chronic wounds.

This study found that TPA induces apoptosis in pig renal epithelial cells by affecting cell cycle proteins, and activated ras can prevent this process.

This narrative review examines advancements in regenerative aesthetic medicine, focusing on injectable modalities like PRP, polynucleotides, and exosomes, but highlights the need for more robust evidence and standardization in clinical applications.

This review discusses the potential benefits of myo-inositol supplementation for insulin resistance-related disorders and diabetic complications, but reports no new clinical results.

This systematic review and meta-analysis found 30 genetic loci associated with skin ageing phenotypes, noting shared biological pathways in aspects like pigmentation and wrinkling; researchers suggest further studies targeting the same SNP across populations could clarify these associations.

This review discusses the potential regulation of signal transduction pathways by microRNAs in animal cells, aiming to identify biological processes that may be influenced by miRNA-mediated regulation, but it reports no new experimental outcomes.

This paper reviews the complex pathophysiology of polycystic ovary syndrome, exploring how hormonal and metabolic disturbances contribute to its symptoms and related health risks, but it presents no new findings.

This review discusses the mechanisms and pathways of FGFR signalling and its roles in development, disorders, and therapeutic targeting, but reports no new clinical results.

This review examines PAK4 signaling pathways in prostate cancer, Parkinson's disease, and melanogenesis, focusing on the potential role of the PAK4-CREB axis, without reporting new clinical results.

This review discusses the relationship between SHBG, NAFLD, and PCOS and reports no new clinical results; the authors highlight low hepatic SHBG production as potentially significant in PCOS pathogenesis.

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

This study reviews recent advancements in understanding caspases, highlighting their roles beyond apoptosis in cancer, inflammation, and neurological disorders, and discusses the potential and challenges of targeting caspases for therapeutic purposes.

This review discusses how targeting TGF-β with specific inhibitors, including components from Traditional Chinese Medicine, may help reduce liver fibrosis by acting through various signaling pathways.

This review provides an in-depth analysis of the structure and function of c-kit activation, and its role in both normal physiological and pathological conditions, with no new research findings reported.

This study found that METTL1 is upregulated in papillary thyroid cancer tissues and promotes cancer cell proliferation and metastasis through its tRNA methyltransferase activity.

This study presents a detailed overview of lymphatic vessel development and highlights the role of abnormal lymphangiogenesis in various diseases, suggesting that targeting lymphangiogenic factors may improve treatment strategies.

This review examines the relationship between glycation, insulin resistance, and PCOS, discussing various treatments and highlighting M. oleifera and S. platensis as potential therapeutic agents, but reports no new clinical results.

This review synthesizes both traditional and emerging molecular mechanisms of tissue remodeling across different organs, aiming to establish a theoretical basis for precision interventions in pathological conditions, according to the authors.

This review discusses the interplay of hyperandrogenism, insulin resistance, obesity, and their role in polycystic ovary syndrome, but presents no new clinical results.