May 2025 in “Frontiers in Bioinformatics” This study used computational methods to identify six molecules, with jamogenin being particularly promising, that effectively bind to and inhibit the enzyme linked to male pattern hair loss, suggesting these compounds could be explored further for hair growth potential.
January 2025 in “International Journal of Biological Innovations” This review article discusses the potential benefits of phytochemicals in hair care, highlighting their ability to improve scalp health, reduce dandruff, and promote hair growth, while emphasizing their safety and minimal side effects compared to conventional therapies.
July 2021 in “Faculty of 1000 Research Ltd” This review discusses the potential of phytochemicals from plants as alternative treatments for prostate cancer, highlighting their possible benefits over current 5-alpha-Reductase inhibitors, but reports no new findings.
June 2021 in “F1000Research” This review explores plant-derived phytochemicals, such as phytosterols, polyphenols, and fatty acids, for their potential use as alternative treatments for prostate cancer, emphasizing their effects on 5-alpha-Reductase enzyme isozymes. It reports no new clinical results.
12 citations
,
November 2017 in “Archives of Dermatological Research” This study suggests that high consumption of raw vegetables and fresh herbs, which are part of the Mediterranean diet, may reduce the risk of androgenetic alopecia in genetically predisposed men.
12 citations
,
May 2023 in “Molecules” This study identified seven potential enzyme inhibitors from a Polygonum cuspidatum extract using ultrafiltration combined with high-performance liquid chromatography. These compounds showed inhibitory activity against tyrosinase, α-glucosidase, and xanthine oxidase, with most discovered in this extract for the first time.
April 2026 in “Cosmetics” In this review, several studies on Astragalus species, particularly Astragalus membranaceus, highlight their skin rejuvenating, photoprotective, antimicrobial, and wound-healing properties, though the authors note limitations due to reliance on non-human studies and short trial durations.
14 citations
,
April 2021 in “Heliyon” This study found that both alcoholic and aqueous extracts of Punica granatum L. showed potential for promoting hair growth and exhibited anti-lice and antidandruff activities in a mouse model.
This study reports that Hair RiseTM microemulsion, made from plant extracts, significantly enhanced hair follicle cell growth and improved hair growth signaling pathways, suggesting it as a plant-based alternative for androgenetic alopecia treatment.
July 2023 in “Pharmacognosy Magazine” This study found that Cerasus serrulata extracts, when obtained through specific methods, demonstrate significant antioxidative and antibacterial properties, as well as potential anti-alopecia effects in a mouse model, potentially making them useful supplements for these purposes.
14 citations
,
November 2012 in “SLAS discovery” This study observed that certain herbal extracts may promote hair growth and inhibit hair loss in cell lines by affecting specific protein expressions similarly to minoxidil.
December 2025 in “Processes” This study found that minoxidil had the highest solubility in shea butter, stearic acid, and rosemary oil, suggesting these natural oils may improve drug loading and encapsulation efficiency in lipid nanocarrier formulations for potential hair growth applications.
3 citations
,
November 2024 in “Current Research in Microbial Sciences” This study found that extracts from the medicinal plants *Echinops echinatus* and *Tridax procumbens* displayed antimicrobial activity against several bacteria, including *Escherichia coli* and *Staphylococcus aureus*, and identified various compounds like flavonoids and terpenoids potentially responsible for these effects.
This study assessed the phytochemical properties and antifungal activity of Lawsonia inermis extracts, finding diverse compounds like flavonoids and alkaloids, and reporting that ethanol extracts exhibited the highest antifungal activity against Aspergillus flavus and Candida albicans at 200 mg/mL.
43 citations
,
September 2021 in “Nutrients” This review discusses the vast potential uses of persimmon beyond its dietary benefits, including applications in sustainability and new product development, but reports no new clinical outcomes.
12 citations
,
December 2023 in “Antioxidants” In this study, researchers found that blackberry leaves exhibited higher liposoluble antioxidant levels and inhibited lipid peroxidation more effectively than raspberry leaves, while raspberry leaves showed greater water-soluble antioxidant content and hydroxyl radical inhibition in vitro.
1 citations
,
June 2024 in “Access Microbiology” This study found that certain non-dermatophytic moulds, specifically *Absidia* sp., *Cladosporium tenuissimum*, and *Aspergillus welwitschiae*, can cause skin symptoms such as discoloration and lesions in albino mice, suggesting potential virulence due to enzyme activity.
This study found that supercritical fluid extraction of germinated perilla seed significantly promoted hair follicle cell proliferation and gene expression related to hair growth, suggesting its potential as a natural treatment for hair loss.
54 citations
,
January 2021 in “Biophysics Reports” This review highlights the current progress and application pros and cons of various cell-based screening platforms in drug discovery, discussing challenges and potential improvements for these innovative methods.
February 2026 in “Cosmetics” This review highlights that Trigonella foenum-graecum L. (fenugreek) shows promise as a versatile plant-based ingredient in cosmetics due to its phytochemicals, which offer benefits for skin and hair care, although further research is necessary for robust validation.
March 2024 in “International journal of pharmaceutical and bio-medical science (Print)” This review examines Angelica sinensis and Chinese arborvitae, highlighting their historical and contemporary use in traditional Chinese medicine and pharmacology. It emphasizes the need for more comprehensive scientific assessments to fully explore their therapeutic potential.
In this study using a virtual screening approach, eriocitrin and silymarin were identified as potent flavonoid compounds that strongly and stably interacted with 5α-reductase type II, suggesting potential development as novel treatments for androgenic alopecia.
25 citations
,
January 2019 in “Journal of Pharmacy And Bioallied Sciences” This study concluded that the formulated polyherbal shampoo is a chemical-free product with nourishing, conditioning, cleansing, and antimicrobial effects.
July 2023 in “Eurasian journal of science and engineering” In this study, researchers reviewed various traditional herbal remedies, such as Tribulus terrestris and Matricaria chamomilla, focusing on their global medicinal use and discussing some of the chemical components that contribute to their biological activity.
27 citations
,
April 2023 in “Pharmaceuticals” In this review, Ziziphus lotus was reported to have multiple traditional uses and demonstrated various pharmacological properties in lab and animal studies, with over 181 identified bioactive compounds; however, clinical trials are needed to confirm its efficacy as a medicinal agent.
49 citations
,
May 2021 in “Bulletin of the National Research Centre/Bulletin of the National Research Center” This review highlights that while scientific validation supports the traditional use of Musa paradisiaca (plantain) primarily for physiological conditions, data on its antiviral and in vivo antimicrobial efficacy is limited, yet its constituent compounds indicate potential for further drug development research.
36 citations
,
April 2022 in “Nutrients” This review discusses the potential of Lansium domesticum as a herbal medicine, summarizing its traditional uses, nutritional value, bioactivities, and related nanoparticles and pharmaceutical formulations, but reports no new experimental results.
9 citations
,
December 2022 in “Antibiotics” This study found that coconut seed extract may effectively treat scabies in rabbits by improving infection signs and causing high mite mortality, suggesting its potential as a cost-effective herbal alternative.
May 2024 in “Molecules/Molecules online/Molecules annual” This narrative review reports that well-selected plant extracts and their active compounds may improve hair health by promoting hair growth and preventing hair loss, potentially aiding in developing targeted therapies for alopecia.
2 citations
,
November 2017 in “Biotechnology Letters” This study developed a high-throughput method that identifies bioactive chemicals influencing DHT production in prostate cancer cells, with potential nutraceutical candidates including fucoxanthin, phenethyl caffeate, and Curcuma longa L. extract.