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This review identifies natural plants that possess androgen-related compounds, highlighting the potential of phytoandrogens as alternatives to allopathic treatments for conditions like hypogonadism, impotence, infertility, and erectile dysfunction.

This review explores current research on how dietary phytochemicals may help manage male androgen disorders by affecting hormone levels and endocrine function, highlighting their potential therapeutic roles and mechanisms in hormonal health, but does not report specific results.

This literature review suggests that herbal extracts show promise as antiandrogenic agents for androgen-related conditions, potentially offering a natural alternative with fewer side effects than synthetic medications.

This review discusses the potential antiandrogenic effects of environmental chemicals on reproductive development, highlighting concerns about their impacts on humans but reports no new clinical findings.

This review discusses the potential of phytochemicals from plants as alternative treatments for prostate cancer, highlighting their possible benefits over current 5-alpha-Reductase inhibitors, but reports no new findings.

In this study, researchers reviewed non-pharmacological treatments for androgenetic alopecia, finding that substances like caffeine, rosemary oil, and saw palmetto may stimulate hair growth or inhibit dihydrotestosterone. They emphasize the need for multicenter clinical trials to further assess these natural products' efficacy in clinical practice.

This review discusses plant-derived phytochemicals, such as phytosterols, polyphenols, and fatty acids, as potential alternatives to 5-alpha-reductase inhibitors for prostate cancer treatment, highlighting their promising anti-cancer properties and potentially fewer side effects compared to conventional drugs.

This review examines the effects of antiandrogens on female reproductive systems, particularly regarding environmental endocrine disruptors, and presents no new research findings.

This study identified 30 new compounds with significant androgen receptor binding affinity through a combination of virtual screening and in vitro testing.

This study found that ethanol-based extracts of Allium sativum and Trigonella foenum-graecum exhibited strong 5α-reductase inhibitory activity, suggesting potential for managing testosterone-induced diseases like androgenetic alopecia.

This mini review explores the potential of herbal testosterone 5α-reductase inhibitors for treating androgenetic alopecia, suggesting they might offer fewer side effects and better tolerability than traditional treatments like finasteride and minoxidil.

This study identified a novel class of nonsteroidal ligands that can mimic the effects of dihydrotestosterone on androgen receptors, suggesting potential therapeutic applications in male fertility and hormone replacement therapy.

The researchers reported that compounds 11 to 13 derived from Westphalen-type steroids showed strong antiandrogenic activity in vivo, though their effects could not be attributed to 5α-reductase inhibition or androgen receptor binding.

This review discusses the clinical use of anti-androgen medications and highlights emerging evidence supporting plant-derived anti-androgens like spearmint tea for managing PCOS, but reports no new clinical results.

This review discusses the biology of antiandrogens and highlights available bioassay models to predict their therapeutic effects on human skin, reporting no new clinical results.

This study found that 60% of men with mild to moderate androgenetic alopecia showed improvement after treatment with botanically derived 5AR inhibitors, suggesting these compounds may be effective, though larger trials are needed.

This review explores plant-derived phytochemicals, such as phytosterols, polyphenols, and fatty acids, for their potential use as alternative treatments for prostate cancer, emphasizing their effects on 5-alpha-Reductase enzyme isozymes. It reports no new clinical results.

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

This review discusses the potential of plant-derived phytochemicals as alternatives to 5-alpha-Reductase inhibitors in treating prostate cancer, highlighting possible benefits like reduced side effects, but it reports no new findings.

This study found that several new pregnane derivatives, especially steroids 16 and 19, demonstrated higher antiandrogenic activity on male hamster models than the commonly used finasteride.

This study found that androgenic steroids, particularly androstenedione and androstanedione, significantly reduced the growth of certain dermatophytes, suggesting hormonal influence on fungal infections in hair follicles.

This study identified Aquilaria sinensis and Piper cubeba as tropical plants with potential anti-androgenic and anti-estrogenic properties that could help prevent or alleviate benign prostatic hyperplasia and prostate cancer.

This study found that several synthesized pregnane derivatives exhibited significant inhibitory effects on testosterone conversion to dihydrotestosterone and reduced related androgenic parameters in multiple pharmacological models.

This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.

In this study, 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides were synthesized and evaluated in vitro as potential 5 alpha-reductase inhibitors and antiandrogens.

This article reviews the use of anti-androgens for dermatological conditions linked to androgen involvement and reports encouraging clinical experiences in females, with use in males limited to specific conditions due to toxicity concerns.

This study observed that new trienone compounds consistently showed higher 5alpha-reductase inhibitory activity compared to corresponding dienones across various biological models.

This study identified six molecules from herbal extracts that effectively bind to 5-alpha reductase (5-AR), with Jomogenin showing high binding stability when encapsulated in lipid nanoparticles, suggesting their potential for further experimental analysis to aid hair follicle growth.