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The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Diet changes can protect against harmful environmental effects on fetal development.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Fungi-produced compounds can change plant root growth.

Some medicinal plants can help heal wounds and may lead to new treatments.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.

Dextran sulfate was found to be toxic and ineffective for treating HIV.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Stress can stop hair growth in mice, and treatments can reverse this effect.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Improving skin barrier and using antifungal treatments can help manage dandruff.