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Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

Nearly all elderly nursing home residents had a skin disease, with dry skin being the most common.

The research found that anovulatory young women have higher androgen and hormone levels than those who ovulate, suggesting immature hormonal regulation rather than a specific condition.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Scalp skin barrier affects hair loss; personalized treatments needed.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

The document concludes that more research is needed to understand how to treat muscle pain with drugs.

Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.

A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.

COVID-19 might affect male fertility, but more research is needed to understand the full impact.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.