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GlossaryPhosphoinositide 3-kinase

enzyme involved in cell growth and survival signaling

Phosphoinositide 3-kinase (PI3K) is an enzyme that plays a crucial role in cell growth, proliferation, and survival by activating signaling pathways inside cells. It is particularly important in the context of cancer research, as abnormal PI3K activity can lead to uncontrolled cell division and tumor growth.

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Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , January 2006 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

research Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia

11 citations , March 2020 in “Dermatologic Surgery”

A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.

research Mixing the Old with the New: Drug Repurposing for Immune Deficiency in the Era of Precision Medicine and Pediatric Genomics

November 2018 in “The Journal of Allergy and Clinical Immunology: In Practice”

Using old drugs for new uses can help treat rare immune deficiencies.

research Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways

73 citations , November 2000 in “Proceedings of the National Academy of Sciences of the United States of America”

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

research Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation

13 citations , November 2014 in “Molecular therapy”

The lentiviral array can monitor and predict gene activity during stem cell differentiation.

research PDGFA regulation of dermal adipocyte stem cells

3 citations , September 2017 in “Stem cell investigation”

PDGF signaling is crucial for maintaining fat stem cells in the skin, and its level of activation can either preserve these cells or cause fibrosis.

Proteomic analysis of fetal skin by iTRAQ reveals molecular signals underlying Inner Mongolia Cashmere goat hair follicle initiation

research Proteomic analysis of fetal skin by iTRAQ reveals molecular signals underlying Inner Mongolia Cashmere goat hair follicle initiation

1 citations , February 2023 in “All Life”

The research identified proteins that change as goat hair follicles begin to form, helping to understand how cashmere grows.

research 743 Adipocyte stem cells are maintained by Pdgfα signaling in the skin

May 2016 in “Journal of Investigative Dermatology”

Pdgfα signaling helps maintain fat cells in the skin and is important for hair growth, wound healing, and fighting infections.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

The research found genes and miRNAs that may control hair growth in Forest Musk Deer.

research The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis

9 citations , April 2006 in “American Journal of Pathology”

SGK3 is essential for proper hair growth and health.

research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

124 citations , October 2019 in “Frontiers in Immunology”

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

research Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique

1 citations , January 2024 in “NPJ breast cancer”

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

research Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

138 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations , June 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway

research Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway

January 2023 in “Indian Dermatology Online Journal”

No single ideal JAK inhibitor for alopecia areata has been determined; JAK3 inhibitors may be promising with fewer side effects.

research Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos

7 citations , September 2019 in “Journal of Cellular Physiology”

Akt2 protein is essential for normal cell division in early mouse embryos.

ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change

research ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change

161 citations , August 2013 in “Journal of experimental botany”

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

research Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway

28 citations , July 2019 in “Life Sciences”

Ginsenoside Rb1 from Panax ginseng helps mink hair grow by activating certain cell signals.

research MicroRNA control of signal transduction

1066 citations , March 2010 in “Nature Reviews Molecular Cell Biology”

MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.

Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

research Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway

4 citations , July 2021 in “Journal of Microbiology and Biotechnology”

Ginsenoside Rg4 from ginseng may help hair growth by activating certain cell signals.

Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia

research Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia

June 2023 in “Frontiers in Medicine”

Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

research An Autophagy-Related Kinase Is Essential for the Symbiotic Relationship between Phaseolus vulgaris and Both Rhizobia and Arbuscular Mycorrhizal Fungi

36 citations , August 2016 in “The Plant cell”

A specific enzyme is crucial for the bean plant's relationship with certain beneficial soil bacteria and fungi.

research Tregs: Where We Are and What Comes Next?

130 citations , November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations , August 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations , January 2023 in “International journal of biological sciences”

Gray hair can potentially be reversed, leading to new treatments.

research Beta-caryophyllene enhances wound healing through multiple routes

3 citations , April 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

Beta-caryophyllene, found in essential oils, helps wounds heal better in multiple ways.

research Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells

22 citations , February 2017 in “Clinical and Experimental Dermatology”

Icariin helps mouse hair grow by boosting a growth factor in skin cells.

research Distinctive Acne Entities

January 2019 in “Springer eBooks”

Acne can appear or persist in adulthood due to hormonal changes, external factors, or substance use, and requires appropriate treatment.

research Targeting receptor–regulator interactions

August 2013 in “Nature Reviews Drug Discovery”

New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.