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    Glossary Phosphoinositide 3-kinase

    enzyme involved in cell growth and survival signaling

    Phosphoinositide 3-kinase (PI3K) is an enzyme that plays a crucial role in cell growth, proliferation, and survival by activating signaling pathways inside cells. It is particularly important in the context of cancer research, as abnormal PI3K activity can lead to uncontrolled cell division and tumor growth.

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    Research 30 of 444

    1. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    2. Vascular Endothelial Growth Factor Protects CD200-Rich and CD34-Positive Hair Follicle Stem Cells Against Androgen-Induced Apoptosis Through the Phosphoinositide 3-Kinase/Akt Pathway in Patients With Androgenic Alopecia Dermatologic Surgery · 2019 · 11 citations
    3. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    4. Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways Proceedings of the National Academy of Sciences of the United States of America · 2000 · 73 citations
    5. Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation Molecular therapy · 2014 · 13 citations
    6. Expression profile analysis of dermal papilla cells mRNA in response to WNT10B treatment Experimental and Therapeutic Medicine · 2019 · 7 citations
    7. PDGFA regulation of dermal adipocyte stem cells Stem cell investigation · 2017 · 3 citations
    8. Proteomic analysis of fetal skin by iTRAQ reveals molecular signals underlying Inner Mongolia Cashmere goat hair follicle initiation All Life · 2023 · 1 citations
    9. Exploring the mechanism of Notopterygii rhizoma et radix in the treatment of psoriasis using a network Pharmacology approach and experimental validation Scientific Reports · 2025
    10. 743 Adipocyte stem cells are maintained by Pdgfα signaling in the skin Journal of Investigative Dermatology · 2016
    11. Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer Animals · 2023
    12. The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits 2020
    13. Mixing the Old with the New: Drug Repurposing for Immune Deficiency in the Era of Precision Medicine and Pediatric Genomics The Journal of Allergy and Clinical Immunology: In Practice · 2018
    14. The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis American Journal of Pathology · 2006 · 9 citations
    15. Phosphatidylinositol 3-Kinase/Akt-Dependent and -Independent Protection Against Apoptosis in Normal Human Melanocytes Journal of Investigative Dermatology · 2004 · 16 citations
    16. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016 · 133 citations
    17. Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique NPJ breast cancer · 2024 · 1 citations
    18. Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells Molecules · 2022
    19. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update Clinical, Cosmetic and Investigational Dermatology · 2015 · 138 citations
    20. Hétérogénéité tumorale du cancer de la prostate et infection par le SARS-CoV2 : une relation complexe impliquant les vésicules extracellulaires et le récepteur des androgènes SPIRE - Sciences Po Institutional REpository · 2023
    21. ERULUS Is a Plasma Membrane-Localized Receptor-Like Kinase That Specifies Root Hair Growth by Maintaining Tip-Focused Cytoplasmic Calcium Oscillations The Plant Cell · 2018 · 32 citations
    22. Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway Indian Dermatology Online Journal · 2023
    23. The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis International Journal of Molecular Sciences · 2018 · 177 citations
    24. Enzymes British Journal of Pharmacology · 2008
    25. AGD1, a class 1 ARF‐GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity The Plant Journal · 2011 · 56 citations
    26. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change Journal of experimental botany · 2013 · 161 citations
    27. Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway Life Sciences · 2019 · 28 citations
    28. TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia Cell Death and Disease · 2016 · 38 citations
    29. Vpliv prehrane na pojavnost aken Repository of the University of Primorsk (University of Primorska) · 2023
    30. Smart Fluids As Autophagy-Activating Photoprotectors: In Vitro Analysis of Dead Sea Water and Magnetized Saline Water Against Ultraviolet B (UVB)-Induced Photodamage in Human Keratinocytes Cureus · 2025 · 1 citations