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    Glossary Phosphatidic Acid-Phospholipase A1 Alpha

    enzyme that breaks down phosphatidic acid in cell membranes

    Phosphatidic Acid-Phospholipase A1 Alpha (PA-PLA1α) is an enzyme that specifically targets and breaks down phosphatidic acid, a type of lipid molecule found in cell membranes. This enzyme plays a crucial role in lipid metabolism and signaling pathways, which are important for various cellular processes, including membrane dynamics and energy storage.

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    Research 30 of 207

    1. Follikelhormone Springer Reference Medizin · 2019
    2. Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6 Proceedings of the National Academy of Sciences · 2025 · 1 citations
    3. Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6 Journal of Biological Chemistry · 2009 · 253 citations
    4. Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin Cellular & Molecular Biology Letters · 2025
    5. Autotaxin–lysophosphatidic acid– LPA <sub>3</sub> signaling at the embryo‐epithelial boundary controls decidualization pathways The EMBO Journal · 2017 · 44 citations
    6. Optimization of photobiomodulation therapy for spinal cord injury: A review Photochemistry and Photobiology · 2025
    7. Extraskeletal actions of vitamin D Annals of the New York Academy of Sciences · 2016 · 119 citations
    8. Vitamin D metabolism and function in the skin Molecular and cellular endocrinology · 2011 · 185 citations
    9. Novel lysophosphoplipid receptors: their structure and function Journal of Lipid Research · 2014 · 158 citations
    10. A Missense Mutation within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2012 · 78 citations
    11. Complete defect in PA-PLA1α secretion function leading to autosomal recessive woolly hair and hypotrichosis: insights from a novel compound heterozygous LIPH variant study in a Chinese pedigree Frontiers in Genetics · 2025
    12. Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin Journal of Biological Chemistry · 2011 · 35 citations
    13. Phospholipase A2 Is Required for PIN-FORMED Protein Trafficking to the Plasma Membrane in the<i>Arabidopsis</i>Root The Plant Cell · 2010 · 84 citations
    14. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010 · 89 citations
    15. A missense mutation in the P2RY5 gene leading to autosomal recessive woolly hair in a Syrian patient Journal of Dermatological Science · 2009 · 13 citations
    16. Progress in the design of ascorbic acid derivative-mediated drug delivery RSC Advances · 2025 · 1 citations
    17. White piedra caused by <i>Trichosporon inkin</i> : a report of two cases in a northern climate British Journal of Dermatology · 2015 · 8 citations
    18. Lysophospholipid Mediators in Health and Disease Annual review of pathology · 2021 · 49 citations
    19. Molecular Genetics of Alopecias Current problems in dermatology · 2015 · 9 citations
    20. Hair growth promoting effects of adipose tissue-derived stem cells Journal of Dermatological Science · 2009 · 81 citations
    21. Woolly Antics between the Sheaths Journal of Investigative Dermatology · 2009 · 1 citations
    22. Diagnosis and treatment of isolated autosomal recessive woolly hair/hypotrichosis Frontiers in Medicine · 2025
    23. Coordination of force-generating actin-based modules stabilizes and remodels membranes in vivo The Journal of Cell Biology · 2024 · 3 citations
    24. Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins Molecular biology of the cell · 2016 · 25 citations
    25. The β9 Loop Domain of PA-PLA1α Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2012 · 11 citations
    26. LPA-producing enzyme PA-PLA<sub>1</sub>α regulates hair follicle development by modulating EGFR signalling The EMBO Journal · 2011 · 151 citations
    27. Highly Prevalent LIPH Founder Mutations Causing Autosomal Recessive Woolly Hair/Hypotrichosis in Japan and the Genotype/Phenotype Correlations PloS one · 2014 · 15 citations
    28. Molecular Genetics of Human Hair Diseases 2008
    29. Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair Nature genetics · 2008 · 210 citations
    30. Autosomal-Dominant Woolly Hair Resulting from Disruption of Keratin 74 (KRT74), a Potential Determinant of Human Hair Texture The American Journal of Human Genetics · 2010 · 97 citations