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GlossaryPhosphatidic Acid

lipid molecule involved in cell membrane structure and signaling

Phosphatidic Acid (PA) is a type of lipid molecule that plays a crucial role in the structure and function of cell membranes. It acts as a precursor for the biosynthesis of other lipids and is involved in cell signaling pathways that regulate various cellular processes, including growth and metabolism.

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Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

research Phosphatidic Acid Has Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells

46 citations, August 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

Phosphatidic acid may help hair grow by affecting cell growth pathways.

research Studies on the Biological Actions of Procyanidins and Phosphatidic Acids on Hair Follicles: Experimental Approaches

January 2006

Procyanidins and phosphatidic acids help promote hair growth.

Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth

research Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth

38 citations, June 2018 in “Plant & cell physiology/Plant and cell physiology”

Changing the amount of PLC5 in Arabidopsis affects root growth and drought resistance, with less PLC5 slowing root growth and more PLC5 improving drought tolerance but hindering root hair growth.

research Exploration of Potential Lipid Biomarkers for Premature Canities by UPLC-QTOF-MS Analyses of Hair Follicle Roots

7 citations, June 2020 in “Experimental dermatology”

Researchers found that certain lipids, especially vitamin D3, are lower in prematurely grey hair than in pigmented hair.

research Glycerophospholipid Analysis of Eastern Red Bat (Lasiurus Borealis) Hair by Electrospray Ionization Tandem Mass Spectrometry

5 citations, February 2014 in “Journal of chemical ecology”

Eastern Red Bat hair contains various glycerophospholipids, mainly phosphatidylcholine.

research LPA3, A Unique G Protein-Coupled Receptor For Lysophosphatidic Acid

31 citations, October 2010 in “Progress in lipid research”

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

research The Role of Lysophosphatidic Acid in the Physiology and Pathology of the Skin

24 citations, December 2018 in “Life sciences”

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

research GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

5 citations, January 2021 in “Journal of Saudi Chemical Society”

Watercress oil may promote hair growth by activating specific receptors.

research Lysophosphatidic Acid and Signaling in Sensory Neurons

20 citations, January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.

research Autotaxin–Lysophosphatidic Acid–LPA3 Signaling at the Embryo-Epithelial Boundary Controls Decidualization Pathways

44 citations, June 2017 in “The EMBO Journal”

LPA3 signaling in the uterus is crucial for placental formation and fetal development.

research Atypical Formations of Gintonin Lysophosphatidic Acids as New Materials and Their Beneficial Effects on Degenerative Diseases

February 2023 in “Journal of Ginseng Research/Journal of ginseng research”

New ginseng compounds may help treat degenerative diseases.

research Non-Edg Family LPA Receptors: The Cutting Edge of LPA Research

68 citations, July 2011 in “Journal of Biochemistry/The journal of biochemistry”

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

24 citations, September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Integrated Transcriptomics and Metabolomics Analyses of Stress-Induced Murine Hair Follicle Growth Inhibition

4 citations, February 2022 in “Frontiers in molecular biosciences”

Chronic stress in mice changes skin metabolism and gene expression, leading to hair loss.

research Vesicles: Potential Nano Carriers for the Delivery of Skin Cosmetics

21 citations, July 2017 in “Journal of Cosmetic and Laser Therapy”

Vesicular carriers like liposomes may improve cosmetic skin treatment delivery and effectiveness but need more human research.

research Phosphatidylinositol-Specific Phospholipase C2 Functions in Auxin-Modulated Root Development

28 citations, December 2018 in “Plant, cell & environment/Plant, cell and environment”

A protein called PLC2 is important for the growth and development of plant roots influenced by auxin.

research A Missense Mutation in the P2RY5 Gene Leading to Autosomal Recessive Woolly Hair in a Syrian Patient

13 citations, November 2009 in “Journal of Dermatological Science”

A gene mutation causes woolly hair in a Syrian patient.

research Risk Factors and Lipid Metabolism Characteristics of Early-Onset Male Androgenetic Alopecia: A Pilot Study

May 2024 in “Journal of cosmetic dermatology”

Low HDL-C, uric acid, and 25-hydroxyvitamin D are risk factors for early-onset male hair loss.

research Syndromes of Severe Insulin Resistance

November 2004

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

research Lysophospholipid Mediators in Health and Disease

49 citations, November 2021 in “Annual review of pathology”

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

research Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin

35 citations, January 2011 in “Journal of Biological Chemistry”

sPLA2-X is crucial for normal hair growth and follicle health.

research Arabidopsis PCaP2 Functions as a Linker Between Abscisic Acid and Salicylic Acid Signals in Plant Water Deficit Tolerance

11 citations, May 2018 in “Frontiers in plant science”

Arabidopsis PCaP2 helps plants survive drought by linking ABA and SA signals.

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations, December 2009 in “Journal of Dermatological Science”

Fat tissue stem cells may help increase hair growth.

Identification of Factors Contributing to Phenotypic Divergence via Quantitative Image Analyses of Autosomal Recessive Woolly Hair/Hypotrichosis with Homozygous c.736T>A LIPH Mutation

research Identification of Factors Contributing to Phenotypic Divergence via Quantitative Image Analyses of Autosomal Recessive Woolly Hair/Hypotrichosis with Homozygous c.736T>A LIPH Mutation

12 citations, July 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

Different hair fiber development might explain why hair loss severity varies in patients with a specific genetic mutation, and treatments that thicken hair could help.

research Tumor Promotion in Skin: Are Active Oxygen Species Involved?

10 citations, January 1985 in “Elsevier eBooks”

Active oxygen species might be involved in skin tumor growth, but their exact role is unclear.

Novel Splice Site Mutation in the LIPH Gene in a Patient with Autosomal Recessive Woolly Hair/Hypotrichosis: Case Report and Published Work Review

research Novel Splice Site Mutation in the LIPH Gene in a Patient with Autosomal Recessive Woolly Hair/Hypotrichosis: Case Report and Published Work Review

9 citations, February 2018 in “The Journal of Dermatology”

A new mutation in the LIPH gene was found to cause a rare hair disorder in a Japanese boy.

research Molecular Genetics of Alopecias

9 citations, January 2015 in “Current problems in dermatology”

Scientists have found specific genes linked to different hair loss conditions, which could lead to new treatments.

research White Piedra Caused by Trichosporon Inkin: A Report of Two Cases in a Northern Climate

8 citations, April 2015 in “British Journal of Dermatology”

White piedra, a rare fungal infection, was diagnosed in two women in a northern climate.

research Topical Minoxidil Improves Congenital Hypotrichosis Caused by LIPH Mutations

7 citations, March 2015 in “British Journal of Dermatology”

Applying minoxidil can help improve hair growth in people with hair loss caused by LIPH gene mutations.

research Hair Graying and Loss Induced by Imatinib Mesylate

7 citations, December 2013 in “The Journal of Dermatology”

A woman's hair turned gray and fell out after starting a cancer drug called imatinib mesylate.