18 citations
,
July 2020 in “Journal of Drug Delivery Science and Technology” This study found that while a nanostructured lipid carrier improved drug delivery in conventional skin models, excess sebaceous content hindered its effectiveness in targeting hair follicles.
18 citations
,
February 2019 in “Scientific Reports” This study found that TSA restored the hair-inductive capacity of skin-derived precursors in mice by enhancing BMP gene expression and signaling through histone acetylation.
13 citations
,
March 2021 in “British Journal of Pharmacology” This study found that KY19382 can effectively promote hair regeneration and follicle neogenesis in mice and human hair models by activating Wnt/β-catenin signalling, suggesting potential use for alopecia treatment.
11 citations
,
August 2019 in “Journal of Molecular Histology” This study found that upregulation of NFIC may enhance proliferation and osteogenic/cementogenic differentiation in rat dental follicle cells.
11 citations
,
April 1982 in “Journal of the Forensic Science Society” This study found that specific enzymes could be detected in fresh hair sheath cells, with most remaining detectable in older cells, except for Adenylate kinase and Esterase D.
10 citations
,
January 2017 in “Expert Opinion on Pharmacotherapy” This review discusses the clinical features and treatment options for adult acne, highlighting the need for tailored management in specific populations, but reports no new findings.
9 citations
,
January 2017 in “Food & Nutrition Research” In this study, rice bran mineral extract increased expression of anagen-related proteins and decreased inflammatory markers in human dermal papilla cells, suggesting potential for hair growth enhancement and prevention of hair loss.
9 citations
,
January 2015 in “Laboratory Animal Research” This study found that oral administration of Laminaria japonica and Cistanche tubulosa extracts may improve hair regrowth in mice, comparable to the effects of 3% Minoxidil, potentially due to their anti-inflammatory properties.
9 citations
,
December 2013 in “Toxicological Research” This study found that Chamaecyparis obtusa oil increased hair follicle cell proliferation and maintained the anagen phase in mice, suggesting a potential for promoting hair growth.
8 citations
,
March 2011 in “Endocrine” In this study, researchers identified a novel p.R50X mutation in the vitamin D receptor gene, linked to hereditary vitamin D-resistant rickets in two siblings.
8 citations
,
April 1965 in “Archives of biochemistry and biophysics” This study found that sheep wool follicles actively oxidize acetate and glucose, suggesting the involvement of the TCA cycle for compound synthesis and the potential role of the pentose phosphate pathway in ribose production for RNA and DNA.
7 citations
,
January 2022 in “Molecules” This study found that tectoridin, an isoflavone from Rhizoma Belamcandae, may stimulate hair growth by activating Wnt signaling in human and mouse cell cultures.
7 citations
,
June 2021 in “Cell Proliferation” This study found that direct interactions between human dermal papilla cells and melanocytes under low oxygen conditions improved cell functions and could be important for hair regeneration efforts.
7 citations
,
March 2021 in “Molecular Medicine Reports” This study demonstrated that culturing high-passage dermal papilla cells with specific supplemented conditioned media may preserve their hair-inducing abilities, suggesting potential for reconstructing new hair follicles in vivo.
7 citations
,
June 2016 in “Bone Research” In this study, a Chinese Han family with hereditary vitamin D-resistant rickets was found to have a homozygous missense mutation in the VDR gene, and the affected individual uniquely responded well to treatment with oral calcium and low-dose calcitriol.
7 citations
,
January 1973 in “Calcified Tissue International” This study found that hair follicle tissue effectively induced mineral formation in calcium phosphate solutions, likely due to its nucleating ability, which was lost when the tissue was lyophilized and stored.
6 citations
,
November 2022 in “Antioxidants” In this study, sandalore was found to activate OR2AT4, which inhibits senescent cell traits and restores proliferation in human keratinocytes, suggesting potential anti-aging applications.
6 citations
,
January 2016 in “Springer eBooks” Invasomes effectively deliver drugs through the skin and have potential for improved treatments.
5 citations
,
July 2024 in “Journal of Microbiology and Biotechnology” This study investigated autophagy activator ICP5249 and found it promotes hair growth by enhancing cell proliferation and autophagy-related markers in human dermal papilla cells and hair follicles, with AMPKα playing a regulatory role, suggesting its potential as a hair growth ingredient.
5 citations
,
October 2021 in “PubMed” This study found that exosomes derived from human adipose stem cells significantly enhanced the proliferation and migration of dermal papilla cells compared to those from platelet-rich plasma, suggesting potential benefits for hair loss treatment.
4 citations
,
June 2022 in “Journal of cleaner production” This study found that a new eco-friendly hair crosslinking method using visible light and non-toxic chemicals caused less damage and improved mechanical properties compared to traditional thioglycolic acid treatment.
4 citations
,
January 2021 in “Archives of dermatological research” This study developed a new human hair research model combining 3D spheroid dermal papilla fibroblasts with plucked anagen hair shafts, potentially improving the evaluation of hair follicle differentiation.
4 citations
,
May 2019 in “Zeitschrift für Naturforschung C” This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.
4 citations
,
January 1994 in “Yakugaku zasshi” In this study, EPC-K, a compound with antioxidant and moisturizing effects, was found to decompose significantly under certain conditions, impacting its stability in quasi drug hair-growing products.
3 citations
,
June 2023 in “ACS sustainable chemistry & engineering” In this study, a method using riboflavin phosphate, citric acid, and polyols successfully optimized protein cross-linking in hair of all colors through visible light-mediated photo-cross-linking, improving the mechanical properties and hair-setting effects without the influence of hair color.
3 citations
,
January 2017 in “Yonsei Medical Journal” This study found that inhibiting 11β-HSD1 can partially reverse the negative impact of glucocorticoids on dermal papilla cells in human scalps, suggesting potential for treating stress-related hair loss.
3 citations
,
November 2005 in “British Journal of Dermatology” In this case study, a 21-year-old man with alopecia universalis experienced temporary hair regrowth after treatment with recombinant human bone morphogenetic protein-2 following a tibial fracture.
2 citations
,
May 2023 in “Marine Drugs” The researchers reported that marine-derived saccharides, specifically L-fucose and chondroitin sulphate disaccharide, supported skin and hair health by promoting cellular proliferation, enhancing extracellular matrix production, and aiding the hair cycle's growth phase, potentially minimizing aging effects.
2 citations
,
May 2021 in “International journal of molecular sciences” This study demonstrated that autologous mesenchymal stem cells from hair follicles, when combined with a novel gelatin-based hydrogel, showed promising osteogenic potential and could offer a non-invasive alternative for bone regeneration.
2 citations
,
May 2012 in “Indian drugs” This study found that a proniosomal gel formulation of finasteride increased anagen hair count in male volunteers with androgenic alopecia by 42.85% compared to the control group.