31 citations
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August 2023 in “ACS Applied Bio Materials” This study developed granular hydrogels with reversible interparticle cross-linking, finding they offer high mechanical stability and enhance cell recruitment, making them promising for injectable and 3D printable scaffolds in tissue engineering and therapeutic delivery.
92 citations
,
February 2023 in “Antibiotics” This review discusses advances in nanomaterial-based wound dressings for infection control, highlighting their ability to detect and treat bacterial infections effectively, but reports no new clinical results.
54 citations
,
March 2024 in “Journal of Medicinal Chemistry” This article summarizes the properties, synthesis, and biomedical applications of molecules with N-oxide functionalities, emphasizing their growing role in healthcare due to their unique properties, such as water solubility and redox reactivity, crucial for drug targeting and cytotoxicity.
48 citations
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July 2023 in “Biomedicines” This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential for disease treatment, but notes challenges in their clinical application.
46 citations
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January 2020 in “Research” This review discusses the design, properties, and potential applications of smart microneedles, with no new clinical results presented.
37 citations
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February 2024 in “Military Medical Research” In this review, biomaterial-based mechanical strategies were highlighted for their potential to enhance skin regeneration and promote scarless repair, though a comprehensive understanding of their underlying mechanisms is still needed for broader application.
37 citations
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December 2022 in “Acta Pharmaceutica Sinica B” This review discusses the strategies and potential of CRISPR delivery for gene therapy, highlighting the challenges and innovative use of stimuli-responsive nanocarriers, but reports no new experimental results.
30 citations
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November 2024 in “ACS Materials Au” This article provides an overview of microneedle technology for transcutaneous drug delivery, discussing microneedle designs, materials, and activation methods that enhance drug stability and regulated release, and outlines considerations for their successful clinical implementation, such as biocompatibility and production cost.
30 citations
,
April 2023 in “Indian Journal of Ophthalmology” This review examines various new approaches for treating dry eye disease, including biomaterials, regenerative therapy, and tissue engineering, and emphasizes the need for clinical efficacy studies to advance these therapies for human use.
26 citations
,
August 2024 in “Frontiers in Bioengineering and Biotechnology” This review aims to systematically evaluate the various types of antimicrobial wound dressings and current research on antimicrobial agents, providing insights for innovative treatments of infected wounds, due to the lack of comprehensive studies on their efficacy in promoting wound healing.
24 citations
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December 2023 in “Gels” In this study, researchers reviewed the progress and challenges in using hydrogels for 3D printing in biomedical applications, highlighting advancements in structural complexity, and identifying ongoing issues like resolution improvement, cell viability, and ethical concerns for clinical use.
22 citations
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November 2023 in “Molecules” This review focuses on recent advances in smart responsive polymer microneedles, which offer precise, on-demand drug delivery triggered by external or physiological stimuli, highlighting significant research implications for transdermal drug administration according to this source.
21 citations
,
January 2022 in “Biomaterials Science” This article reviews CRISPR/Cas system delivery methods for genome editing and highlights RNA's promise in non-viral in vivo applications but reports no new clinical results.
19 citations
,
January 2023 in “ACS Omega” This study developed sodium alginate and epigallocatechin gallate cryogels cross-linked with ferric ions, showing that they have strong antibacterial properties and rapid hemostatic abilities, making them promising candidates for wound dressing applications.
14 citations
,
February 2023 in “Frontiers in Bioengineering and Biotechnology” This review details various components used in hydrogel composites for treating chronic diabetic ulcers and highlights potential future materials but reports no new empirical findings.
10 citations
,
June 2023 in “Preprints.org” This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential and challenges for clinical application, but it reports no new clinical findings.
10 citations
,
April 2023 in “Acta biomaterialia” This study reported that a newly developed bioadhesive and injectable hydrogel dressing, incorporating hyaluronate-gelatin and the antibiotic doxycycline, accelerated burn wound healing and skin regeneration in rats, highlighting its potential for clinical applications in burn injury therapy.
8 citations
,
January 2019 in “Nanomedicine” This commentary reviews the application of pharmaceutical nanotechnology in Egypt, highlighting promising developments and diverse drug-delivery approaches, but reports no new research findings.
7 citations
,
August 2022 in “Journal of Nanobiotechnology” This review discusses recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlighting their design rationales and potential biomedical applications, but reports no new experimental results.
6 citations
,
February 2023 in “Biomaterials Research” This review explores the different types of hydrogels used to repair diabetic ulcers, the mechanisms involved, and the limitations in developing these technologies for clinical use, but it reports no new clinical results.
4 citations
,
September 2025 in “Pharmaceutics” This review highlights the potential of natural hydrogels as advanced wound dressings, emphasizing their capabilities in mimicking the extracellular matrix, supporting healing, and delivering therapeutic agents for chronic and infected wound care.
2 citations
,
November 2025 in “Comprehensive Reviews in Food Science and Food Safety” This review discusses the growing role of colorimetric sensors in food safety, highlighting their potential to enhance detection accuracy and manageability, while also noting challenges such as environmental interference and the need for further industrial validation.
1 citations
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December 2025 in “Inorganics” This review analyzes the role of silver nanoparticles in wound healing, highlighting their antimicrobial, anti-inflammatory, and tissue-regenerating properties, and emphasizes the need for further research to optimize formulations and ensure safety.
1 citations
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April 2023 in “International Journal of Molecular Sciences” This review discusses advances in CRISPR/Cas9 variants and nanoformulations for cancer treatment, noting challenges and prospects for clinical application, but reports no new research results.
August 2026 in “Molecular Biomedicine” This review outlines the design and engineering of multifunctional hydrogels, emphasizing their evolving biomedical applications, notably in controlled drug delivery, tissue support, and disease management, and discusses their potential for clinical translation.
April 2026 in “Pharmaceutics” This review highlights cellulose-based materials' potential in skin disease treatments, emphasizing their smart, responsive design for various conditions, with insights into their roles in wound healing, infection prevention, and wearable monitoring.
January 2026 in “Regenerative Biomaterials” This study highlights that hydrogel formulations unexpectedly prolonged healing in trials, pointing to a need for design based on detailed pathophysiological insights rather than empirical methods, and suggests technologies like AI materials optimization and 3D bioprinting to aid their clinical use for cancer survivors.
December 2025 in “Rare Metals” This review assesses the potential of smart dressings, engineered to respond to various stimuli, as advanced treatments for chronic inflammatory skin diseases by examining their activation mechanisms and proposing future developments like integrating AI and closed-loop monitoring for adaptive therapy.
September 2025 in “Pharmaceutics” This review examines recent advances in androgenetic alopecia treatment, highlighting how multifunctional plant extracts combined with nanotechnology could improve topical therapy efficacy by enhancing local drug bioavailability and targeting, addressing limitations of existing treatments.
March 2024 in “Journal of pharmacy & pharmaceutical sciences” This review discusses the design strategies and applications of long-acting polymeric microneedles, noting their potential to improve patient compliance and reduce side effects in chronic disease management, but reports no new experimental results.