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In this study, 1'-S-1'-acetoxychavicol acetate (ACA) from Alpinia galanga showed potential in suppressing testosterone-induced hair loss by inhibiting Nox isozymes in a mouse model of androgenetic alopecia.

This study found that minoxidil is bioactivated through sulfation by the phenol-sulfating form of phenol sulfotransferase in human liver.

This review discusses recent molecular biology advances in the human phenol sulfotransferase gene family and reports no new results; the authors highlight its relevance for studies of endogenous and xenobiotic metabolism.

This study found that 88% phenol treatment significantly improved texture, pigmentation, and density of hair regrowth in alopecia areata patients over nine weeks, with 78% showing a good to excellent response.

This study found that six sessions of a modified phenol peel effectively reduced hyperpigmentation in patients with Lichen Planus Pigmentosus, with 76% of treated individuals experiencing at least a 25% improvement, and no serious side effects reported.

This review details phenol's dermatological uses and underscores its potent skin rejuvenation effects but emphasizes the need for caution due to risks of serious complications, including cardiac arrhythmias and organ failure, particularly with improper use or large-area applications.

This study explored spontaneous repigmentation after phenol-croton oil peels in skin of color, finding that temporary hypopigmentation resolved by day 21 in both a black-skin domestic pig model and human clinical observations, highlighting potential for these procedures despite past concerns about pigmentation issues.

In this study, researchers found that both thermolabile and thermostable forms of phenol sulfotransferase contribute to the sulfation of minoxidil, emphasizing the need to consider both enzymes in assessing sulfation in human tissues.

This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.

This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

This study found that four synthesized thiazolidinone derivatives showed potential anticancer activity against MCF7 and HeLa cell lines, suggesting their further investigation for anticancer drug development.

This paper discusses the role of steroid sulfatase in hormone-dependent tumors and highlights the development of potent inhibitors, noting the commencement of a phase I trial for one inhibitor in postmenopausal breast cancer patients.

This review summarizes the ethno-medicinal uses, phytochemical constituents, and biological activities of Acorus calamus, highlighting its potential therapeutic benefits and the importance of further scientific work on this plant.

This study found no evidence that the tested hair dye ingredients undergo hepatic metabolism to reactive oxidized metabolites in human liver microsomes and hepatocytes.

This study found that hair luster increased with higher fiber pigmentation and application of specific cosmetic oils and styling resins, while micronized ZnO and synthetic sebum dulled hair.

This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.

This review discusses the potential use of spin traps in cosmetic products to limit reactive oxygen species generated by pollution, emphasizing the need for further research due to toxicity and regulatory concerns.

This study identified the structures of cyclohexyl and phenyl analog impurities in finasteride using HPLC and spectral analysis.

This study found that a novel thiohydantoin derivative, 3a, effectively inhibited androgen receptor activity in LNCaP cells and showed promising in vivo results by reducing testosterone-induced prostate changes, outperforming finasteride in mitigating prostate index and histopathological alterations.

This study found that pigmentation following sclerotherapy is likely caused by hemosiderin deposition from red blood cells rather than post-inflammatory hyperpigmentation, with most cases resolving spontaneously within 6–24 months.

This review discusses the effectiveness and potential complications of medium-depth and deep chemical peels for improving skin appearance and reports no clinical results; it highlights the need for careful procedure application.

This study found that 17β-oestradiol reduces lipogenesis but not cell division in human sebaceous glands over 7 days, while testosterone and dihydrotestosterone showed no effect on these processes.

In this study, oral calcium pantothenate was associated with improvement in the inflammatory phase of discoid lupus erythematosus of the scalp, with the most marked response observed in subacute cases.

This animal study observed that while topical MBEH and intraperitoneal phenol induced hair graying in eumelanic mice, they had little effect on pheomelanic mice, and amcinonide reduced certain epidermal melanocytes in both.

Skin surgery has significantly advanced since 1950, with improvements in chemical peels, hair restoration, lasers, and Mohs surgery, and the development of less invasive techniques and specialized training.

This study found that chemical lumbar sympathectomy with 5% phenol effectively treated idiopathic livedo reticularis in most patients, offering a potential long-lasting solution with repeatable efficacy upon recurrence.

This study found that hair dyes significantly affect DNA sequence analysis, with the organic extraction method performing better on hair shafts and the prepFiler kit yielding higher success for follicle-included samples.

No treatment reliably changes Alopecia Areata's course; reassurance and possibly a wig are recommended.

This study found that Staphylococcus aureus delays wound healing by utilizing quorum sensing to impair lipid metabolism in keratinocytes, an effect not observed with commensal Staphylococcus, highlighting the impact of agr-dependent virulence factors in this process.