Search

everythinglearnresearchcommunity

for

Search:↓

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

Microemulsions could improve how drugs are delivered and absorbed in the body.

Minoxidil needs activation to work, and minoxidil sulfate helps with hair growth and blood pressure.

Monocyclic aromatic compounds are important for developing various drugs and treatments.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

Eclipta alba has many health benefits and contains compounds with potential for drug development.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Tretinoin gel is safe for sun exposure, but tacalcitol doesn't significantly improve non-segmental vitiligo.

Synthetic antioxidants are effective, cheap, and stable, with some like zinc and cholecalciferol reducing child and cancer deaths, but the safety of additives like BHA, BHT, TBHQ, and PEG needs more research.

Juglone from walnut extracts may help repair damaged hair.

New treatments like nanotechnology show promise in improving skin cancer therapy.

Minoxidil activates hair growth by being sulfated by P-PST in the human liver.

Early treatment and lifestyle changes are important for managing PCOS in young people to prevent long-term health issues.

Seaweeds contain beneficial compounds with potential uses in food, cosmetics, and health, but more research is needed to improve extraction and safety.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

Finasteride safely treats enlarged prostate and male-pattern baldness.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.