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Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Finasteride reduces hairiness and androgen levels in women with unexplained excessive hair growth.

Advanced human skin models improve drug development and could replace animal testing.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

The document concludes that early recognition and treatment of primary cicatricial alopecia is crucial to prevent permanent hair loss.

Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.

Neurosteroids show promise for treating epilepsy and more research is needed.

Microneedle technology has improved drug delivery and patient comfort but needs more research for broader use.

Dienogest combined with ethinylestradiol is a highly effective birth control that improves menstrual symptoms and has manageable side effects.

PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.

Some birth control pills have a higher risk of blood clots than others.

Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

Albendazole treatment for echinococcosis can cause serious side effects and requires close monitoring.

Nanotechnology in dermatology shows promise for better drug delivery and treatment effectiveness but requires more safety research.

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

Cyclosporin is effective for treating skin conditions in small animals, but requires careful dosing and monitoring for side effects.

Biotin supplements are not proven to improve hair or nails and may interfere with medical tests.

Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Alopecia common in teens, may indicate endocrine issue, minoxidil effective treatment.