November 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found an IFIS incidence rate of 3.18% among cataract surgeries in a Chinese hospital and identified reserpine, clozapine, and post-panretinal photocoagulation as new risk factors.
August 2024 in “Journal of Personalized Medicine” In this study using a rabbit model, higher incidences of intraoperative floppy iris syndrome were observed in animals given the α-blocker tamsulosin, suggesting a potential association with increased iris billowing during eye surgery.
3 citations
,
October 2015 in “PubMed” This study found an increased risk of intraoperative iris billowing in rabbits treated with finasteride, similar to those treated with tamsulosin, suggesting further research in humans is needed.
22 citations
,
March 2018 in “International Ophthalmology” This study found that tamsulosin, finasteride use, and aging are significantly associated with increased risk of intraoperative floppy iris syndrome during cataract surgery, while doxazosin does not appear to pose this risk.
22 citations
,
June 2011 in “Acta Ophthalmologica” This study found that current use of benzodiazepines, α1-blockers (like tamsulosin, alfuzosin, terazosin), finasteride, and possibly rivastigmine is associated with increased risk of intraoperative floppy iris syndrome in cataract surgery patients.
3 citations
,
February 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review discusses the challenges of managing intraoperative floppy iris syndrome during cataract surgery and highlights the importance of preoperative risk assessment and multidisciplinary collaboration, reporting no new clinical results.
August 2013 in “Acta Ophthalmologica” This study found that medications including benzodiazepines, quetiapine, and certain alpha-blockers, along with hypertension and short axial length, were independently associated with an increased risk of Intraoperative Floppy Iris Syndrome during cataract surgery.
29 citations
,
October 2001 in “British Journal of Ophthalmology” In this case, intralesional cidofovir was reported to successfully treat SCC without systemic toxicity, suggesting it may be considered as an alternative to surgical excision.
29 citations
,
May 2011 in “Journal of Cataract and Refractive Surgery” This case report suggests a possible association between long-term finasteride use for male pattern baldness and the development of cataracts and intraoperative floppy-iris syndrome in a patient.
28 citations
,
February 2020 in “Clinical Ophthalmology” This article discusses intraoperative floppy iris syndrome during cataract surgery and highlights the importance of awareness and preoperative documentation of its risk factors, emphasizing a multidisciplinary approach to management.
12 citations
,
October 2001 in “British Journal of Ophthalmology” This paper suggests intralesional cidofovir as a potentially effective treatment for SCC with no systemic toxicity observed, but surgical excision remains the standard for its curative outcomes and thorough evaluation.
49 citations
,
December 2007 in “Journal of Cataract and Refractive Surgery” This case report suggests that oral finasteride, used for benign prostatic hyperplasia, may be associated with intraoperative floppy-iris syndrome during cataract surgery.
41 citations
,
December 2008 in “Current Opinion in Ophthalmology” This review describes techniques to manage intraoperative floppy iris syndrome linked to alpha-1 blocker use in cataract surgery, highlighting the need for patient disclosure of medication use but reports no new clinical results.
January 2023 in “Pakistan Armed Forces Medical Journal”
7 citations
,
July 2011 in “Survey of Ophthalmology” This guide provides a comprehensive approach to diagnosing periocular hair disorders, which can range from benign conditions to those posing serious health risks.
3 citations
,
October 2018 in “Experimental and Therapeutic Medicine” In this study, researchers found that discontinuing tamsulosin for one month before cataract surgery in rats reduces manifestations of intraoperative floppy iris syndrome, suggesting alternative preoperative treatments may be beneficial.
March 2024 in “Cleveland Clinic journal of medicine” This review details contemporary medical management options for benign prostatic hyperplasia, highlighting the expanding role of phosphodiesterase-5 inhibitors and beta-3 agonists, but reports no new clinical findings.
October 2022 in “Journal of Pharmaceutical Negative Results” This review examines the therapeutic effects of photobiomodulation on severe medical illnesses but reports no new clinical results; it emphasizes its potential in neurology, pulmonology, inflammation, dermatology, wound healing, and oncology.
January 2014 in “Side effects of drugs annual” This review discusses the 2011 publications on the side effects of sex hormones and related compounds, without reporting new clinical results.
January 2009 in “Side effects of drugs annual” This study observed no teratogenic effects of oral decongestants and surprisingly favorable neonatal outcomes in Swedish women who used them during pregnancy.
March 2017 in “Fundamental & Clinical Pharmacology” This case study reported an improvement in lower limb edema for a patient with type 2 diabetes mellitus after starting dulaglutide treatment, suggesting a potential role of the drug in sodium retention disorders.
19 citations
,
January 2020 in “Journal of Biophotonics” This study found that using a PEG-400/oleic acid mixture as an optical clearing agent enhanced the detection depth of particles in skin without causing dehydration, based on tests in rats and further testing in vivo.
May 2013 in “Optometry and Vision Science” This research reports that partial orthokeratology combined with daytime spectacle correction effectively slowed myopic progression in high myopes, with a 63% reduction in axial elongation compared to spectacle use alone.
December 2012 in “Shodhganga” 23 citations
,
October 2021 in “AAPS PharmSciTech”
1 citations
,
February 2025 in “Notulae Scientia Biologicae” In this study, researchers developed an in-situ gel formulation of antibacterial Levofloxacin for the eye, which showed prolonged drug release, increased residence time, and effective antibacterial action, suggesting it may be a safe and effective ocular delivery system for antibiotics.
13 citations
,
January 2019 in “Colloids and Surfaces B: Biointerfaces” This study found that incorporating a block copolymer significantly alters the size and morphology of niosome drug delivery systems made of non-ionic surfactants and cholesterol, affecting their stability.
13 citations
,
October 2001 in “British Journal of Ophthalmology” This report discusses the use of intralesional cidofovir and suggests it might be a viable option for treating SCC due to its successful outcome without observed systemic toxicity in this case.
This study evaluated amphiphilic self-assembling peptides as drug delivery systems and found they effectively ensured prolonged release and therapeutic efficacy for timolol in glaucoma and for chemotherapy agents in cancer treatment, with significant tumor size reduction observed in animal models.
52 citations
,
January 2001 in “Eye” This review discusses challenges in treating CMO associated with uveitis and highlights the need for prospective studies to guide therapy, as current treatments are largely empirical and potentially harmful.