research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis
Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
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research Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives
Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
research The British Society for Rheumatology Guideline for the Management of Systemic Lupus Erythematosus in Adults
The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.
research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human
Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.
research Androgens Protect Against Apolipoprotein E4-Induced Cognitive Deficits
Androgens can help prevent memory problems caused by apoE4.
research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis
Certain mutations in a hair growth-related gene cause a type of genetic hair loss.
research AXR3 and SHY2 Interact to Regulate Root Hair Development
AXR3 and SHY2 genes control the growth and timing of root hair development in plants.
research The Harmonies Played by TGF-β in Stem Cell Biology
TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.
research The Pharmacology of Methotrexate
Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
research Protoporphyrin IX: The Good, the Bad, and the Ugly
Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.
research Hormesis And Medicine: Biphasic Dose-Response Relationship
Low doses of some substances can be beneficial, while high doses can be harmful or toxic.
research Differential Auxin-Transporting Activities of PIN-Formed Proteins in Arabidopsis Root Hair Cells
Different PIN proteins affect plant root hair growth by changing how auxin is transported.
research External Genitalia Abnormalities in Male Rats Exposed In Utero to Finasteride, a 5α-Reductase Inhibitor
Finasteride exposure in pregnancy causes genital abnormalities in male rats.
research Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues
Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.
research The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double-Blind Study
Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.
research Significant Correction of Disease After Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia
Giving a special protein to dogs with a certain genetic disease improved their symptoms but didn't help with hair growth.
research Ontogenetic Transition in Fetal Wound Transforming Growth Factor-Beta Regulation Correlates with Collagen Organization
Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.
research Stratum Corneum Dysfunction in Dandruff
Improving skin barrier and using antifungal treatments can help manage dandruff.
research The Cytology and Cytochemistry of the Wool Follicle
Wool follicles are complex, involving interactions between different cell types and structures.
research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide
Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.
research Hair Cycle-Specific Expression of Versican in Human Hair Follicles
Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.
research Green Tea: Health Benefits
Green tea may help with health issues like cancer, heart disease, and weight loss due to its high catechin content.
research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil
Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
research The Peripheral Clock Regulates Human Pigmentation
Certain genes control the color of human hair by affecting pigment production.
research Development and Progression of Alopecia in the Vitamin D Receptor Null Mouse
Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.
research Mycorrhiza-Induced Changes in Root Growth and Nutrient Absorption of Tea Plants
AMF inoculation boosts tea plant growth and nutrient absorption.
research Keratinocyte-Specific Ablation of the NF-κB Regulatory Protein A20 (TNFAIP3) Reveals a Role in the Control of Epidermal Homeostasis
A20 protein is crucial for normal skin and hair development.
research Dermatologic Manifestations of Polycystic Ovary Syndrome
Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.
research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion
The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.
research Ovarian Leukocyte Distribution and Cytokine/Chemokine mRNA Expression in Follicular Fluid Cells in Women with Polycystic Ovary Syndrome
Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.