81 citations
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February 1997 in “Journal of Investigative Dermatology” This study suggests that minoxidil activates PGHS-1, which may explain its hair growth-stimulating effects and could aid in designing more potent hair growth-promoting drugs.
7 citations
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July 2020 in “Dermatologic therapy” This review discusses premature graying of hair, highlighting risk factors like smoking and vitamin deficiencies, and suggests that addressing underlying conditions may reverse the graying process.
July 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” This review assessed the role of scalp hair Survivin protein in individuals with premature graying, exploring its potential involvement in graying-related processes and highlighting its overexpression in autoimmune diseases that may influence the survival of specific immune cell clones.
December 2024 in “Current Cosmetic Science” This review introduces Ayurvedic remedies as a promising natural treatment for premature greying of hair, highlighting the use of Vedic plant taxonomy to accurately identify herbs that stimulate melanogenesis and restore hair pigmentation, offering a safer alternative to conventional chemical treatments.
November 2024 in “Jurnal Biomedika dan Kesehatan” This study explores premature graying of hair, outlining potential causes such as genetic factors, nutritional deficiencies, and autoimmune disorders, and evaluates various management strategies including nutritional supplements, pharmacotherapy, and addressing underlying conditions.
June 2024 in “Benha Journal of Applied Sciences” This study suggests that ischemia-modified albumin may play a role in premature hair graying and vasogenic erectile dysfunction, potentially serving as indicators of susceptibility and severity.
In this report, a unique case of premature graying in a 32-year-old male, with onset at age 15 and a distinctive fractal pattern, was presented, highlighting the need for further investigation into its potential causes and mechanisms.
April 2024 in “Nepal journal of dermatology, venereology & leprology” This article discusses the challenges in understanding and treating premature graying of hair and calls for more extensive research, reporting no new findings.
In this study, researchers found a strong association between premature graying of hair and deficiencies in vitamin D and B12, hypothyroidism, and deranged iron profiles, along with higher stress, altered appetite, smoking, and sleep pattern issues, significantly impacting quality of life.
This study found a significant association between premature greying of hair and deficiencies in vitamin D, vitamin B12, hypothyroidism, and disrupted iron profiles, alongside lifestyle factors like stress and smoking.
January 1999 in “Journal of S C C J” This study found that STAT3 signaling is essential for initiating the hair growth phase but not involved in hair follicle development during the fetal period.
May 2026 in “Archives of Dermatological Research” In this study, serum levels of vitamin C, vitamin E, and total antioxidant capacity did not differ significantly between individuals with premature greying hair and controls, but a strong association with family history was observed.
October 2024 in “Journal of Cosmetic Dermatology” This study in Saudi Arabia found that 55.9% of participants reported premature graying of hair before age 30, with risk factors including genetic, health, and lifestyle aspects such as smoking, anxiety, nutrient deficiencies, and family history.
April 2025 in “Dermatology Practical & Conceptual” In this study, researchers observed that individuals with premature graying of hair had significantly higher LC3 gene expression compared to controls, suggesting a potential link between autophagy and the development of this condition, with LC3 gene expression as a possible independent predictor.
October 2024 in “Journal of the Pakistan Medical Association” This letter discusses the various risk factors associated with premature greying of hair, highlighting genetic predispositions, nutritional deficiencies, stress, and lifestyle factors, while noting a lack of conclusive data on effective interventions, as detailed in the reviewed studies.
June 2025 in “Bioinformation” This study found that nearly one in four young adults in a dermatology clinic had premature greying of hair, influenced by genetic factors, lifestyle, and micronutrient levels.
January 2025 in “International Journal of Herbal Medicine” In this case study, a 27-year-old male with premature greying of hair saw significant improvement in hair whitening after ten weeks of treatment with Unani formulations, despite no family history or systemic disorder.
April 2026 in “Indian Dermatology Online Journal” This study found that individuals with premature graying of hair in India had significantly lower levels of serum ferritin, vitamin B12, and vitamin D3 compared to controls.
18 citations
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May 2014 in “Menopause” This study found that a 5-mg daily dose of transdermal testosterone cream in postmenopausal women restored testosterone levels to those typical of premenopausal women.
16 citations
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January 2013 in “Pediatric Gastroenterology Hepatology & Nutrition” This study found that azathioprine treatment in Korean children with inflammatory bowel disease frequently led to adverse events, with bone marrow suppression being the most common.
165 citations
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September 2003 in “Toxicology and applied pharmacology” This review discusses the pharmacology and toxicology of cyclooxygenase in skin, highlighting its role in inflammation, wound healing, and tumorigenesis, without presenting new clinical results.
65 citations
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August 2007 in “Experimental Dermatology” This study found that prostaglandin metabolism enzymes are present in human hair follicles, suggesting a potential role in hair growth and differentiation, with some expression differences between men and women.
20 citations
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March 2013 in “Journal of Lipid Research” This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.
9 citations
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January 2014 in “Medical Hypotheses” This article discusses the hypothesis that mechanisms driving androgenic alopecia may reduce the risk and proliferation of prostate cancer by increasing prostaglandin D2 levels but presents no new clinical findings.
5 citations
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July 2014 in “Acta Crystallographica Section D-biological Crystallography” This study reports that mutations in human L-PGDS affect the entrance and exit of ligands in its binding cavity, suggesting these residues play a role in ligand interaction processes.
1 citations
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February 2021 in “International Journal of Research in Dermatology” This study found that premature graying significantly impacts the quality of life among affected individuals, reporting profound effects on psychological and social well-being, including guilt and mood fluctuations.
January 2026 in “International Journal of Science and Research Methodology” This review explored the therapeutic potential of Bhangra (Eclipta alba) for treating premature greying of hair, noting the plant's melanogenic, antioxidant, and revitalizing properties, but highlighted the need for further research to scientifically support its effectiveness.
January 2026 in “Military Medicine” This article discusses how lipopolysaccharide (LPS) from gram-negative bacteria activates platelets and affects vascular responses, emphasizing the role of reactive oxygen species (ROS) in these processes, without reporting new experimental findings.
397 citations
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February 2004 in “British Journal of Dermatology” This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.
281 citations
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January 2013 in “British Journal of Dermatology” Manage vitiligo with treatments, address emotions, and use camouflage techniques.