67 citations
,
March 2021 in “Dermatology and Therapy” This review discusses the substantial impact of alopecia areata on patients' health-related quality of life, highlighting issues such as personality changes, emotional and social difficulties, and a common occurrence of alexithymia, and emphasizes the need for more specific assessment tools.
66 citations
,
June 2021 in “Journal of The American Academy of Dermatology” In this phase 2 study, baricitinib at 2 mg and 4 mg doses significantly improved hair regrowth in adults with alopecia areata and ≥50% scalp hair loss compared to placebo, without new safety concerns, although the small sample size limits the results' generalizability.
56 citations
,
October 2018 in “Journal of The American Academy of Dermatology” This review discusses the role of androgens in women's skin-related conditions like acne, hirsutism, and female pattern hair loss, noting the lack of dermatology guidelines for when to pursue endocrinologic evaluation.
55 citations
,
October 2019 in “Dermatology and therapy” This review found that JAK/STAT pathway inhibitors, such as tofacitinib and ruxolitinib, led to symptom improvement in all observed atopic dermatitis cases, but responses were mixed for vitiligo and alopecia areata, with a generally mild safety profile reported.
55 citations
,
March 2009 in “Journal of The American Academy of Dermatology” This study found that latanoprost and bimatoprost, when applied cutaneously to the eyelids, did not induce appreciable eyelash regrowth in patients with alopecia areata over 16 weeks.
55 citations
,
January 2007 in “Climacteric” This paper reviews guidelines discussed at a meeting about research and practice themes, but reports no new research findings.
55 citations
,
January 2002 in “Journal of liposome research” This research explores developing liposomal formulations to enhance the delivery of difficult-to-absorb agents directly to hair follicles and sebaceous glands, with minoxidil and plasmid DNA as study molecules.
54 citations
,
November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology” This chapter reviews keratins in skin epithelia, including their roles in cellular function and disease, and reports no new experimental results.
53 citations
,
January 2018 in “JAAD case reports” This report describes the case of a patient who developed alopecia areata within five weeks of starting treatment for atopic dermatitis with dupilumab.
51 citations
,
June 2016 in “Journal of the European Academy of Dermatology and Venereology” In this study, tofacitinib treatment was associated with significant hair regrowth in two patients with alopecia universalis over eight months, with minimal adverse effects reported.
49 citations
,
July 2021 in “Nutrients” This review explores lifestyle modifications for women with polycystic ovary syndrome, discussing dietary, physical, and supplementation strategies, but reports no new clinical results.
48 citations
,
November 2017 in “Journal of the American Academy of Dermatology” Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.
40 citations
,
December 2016 in “Journal of Dermatological Treatment” This study reviewed the role of the JAK/STAT signaling pathway in skin diseases and the potential of JAK inhibitors for treating conditions like psoriasis and atopic dermatitis. Although the findings are promising, the authors concluded it is premature to establish their place in dermatological treatments.
40 citations
,
September 2018 in “Journal of the American Academy of Dermatology” This letter discusses the emerging use of Janus kinase inhibitors, specifically oral tofacitinib, for treating alopecia areata in children, but reports no new clinical findings.
39 citations
,
March 2022 in “Infection” Many recovered COVID-19 patients in Saudi Arabia still experience symptoms like fatigue and anxiety, especially older adults and those with other health issues.
39 citations
,
April 2010 in “International Journal of Pharmaceutics” This study found that using monoolein cubic phase nanoparticles with an entrapped hydroxypropyl β-cyclodextrin/minoxidil complex increased minoxidil skin permeation, but minoxidil retention in the skin was higher with a traditional solution.
37 citations
,
September 2018 in “The Journal of Clinical Endocrinology and Metabolism” This study found that intravaginal testosterone significantly improved sexual satisfaction and reduced dyspareunia in postmenopausal women using aromatase inhibitors, with no effect on urinary incontinence.
36 citations
,
January 2018 in “Scientific reports” This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.
36 citations
,
December 2017 in “Journal of the American Academy of Dermatology” This study observed that 70.7% of patients with frontal fibrosing alopecia stabilized with treatment, and patients using 0.3% tacrolimus were more likely to stabilize in 3 months compared to other treatments.
36 citations
,
November 2005 in “Journal of The American Academy of Dermatology” This article discusses the potential of latanoprost for treating alopecia areata, but notes that well-controlled studies are still needed to confirm its effectiveness.
36 citations
,
March 2002 in “Journal of Biological Chemistry” Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.
35 citations
,
June 2018 in “Urology” This study of FAERS data suggests that finasteride, particularly at the 1 mg dosage, is associated with a wide range of adverse effects not previously established in long-term studies, especially among younger men.
35 citations
,
January 2004 in “European journal of oncology nursing” In patients undergoing treatment with capecitabine for colon cancer and metastatic breast cancer, this study observed that hand-foot syndrome occurred more frequently than with intravenous 5-FU, but other side effects were less common.
34 citations
,
October 2018 in “Journal of The American Academy of Dermatology” This review discusses hormone-modulating therapies for androgen-mediated cutaneous disorders in women but reports no new clinical results and highlights the need for more rigorous studies.
34 citations
,
July 1999 in “Journal of The European Academy of Dermatology and Venereology” Iron deficiency is not a significant cause of hair loss in women.
33 citations
,
October 2013 in “Journal of The American Academy of Dermatology” In this study, pioglitazone treatment in patients with lichen planopilaris showed limited success, with significant improvement seen in only a minority of cases.
32 citations
,
April 2019 in “JAAD case reports” This study discusses the immune dysregulation observed in individuals with Down syndrome, highlighting their increased risk for autoimmune skin conditions, but does not yet clarify the molecular mechanisms behind this profile.
32 citations
,
August 2003 in “Journal of the American Academy of Dermatology” This case report describes three adults with inflammatory tinea capitis mimicking bacterial infection, emphasizing the need to consider this diagnosis in similar cases; all were successfully treated with oral antifungal agents.
31 citations
,
October 2016 in “PLoS ONE” This study suggests that UMPP activation is a key signaling pathway in differentiating primary and secondary hair follicles in cashmere goats.
31 citations
,
September 2006 in “The Journal of Clinical Endocrinology & Metabolism” This article discusses the development of a transdermal testosterone patch for postmenopausal women to deliver physiological testosterone levels but reports no new clinical results, highlighting a need for long-term safety data.