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5 alpha reductase inhibitors can cause sexual, cognitive, and muscle side effects, and may slightly increase aggressive cancer risk.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

Polycystic Ovary Syndrome (PCOS) is a hormonal disorder in women that can cause infertility and other health issues, and it may be improved by treatments that increase insulin sensitivity.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.

COVID-19 may harm male fertility and damage the reproductive system.

Forensic medicine is crucial for justice and needs continuous innovation and technology integration.

Microglia, the brain's immune cells, may contribute to Polycystic Ovary Syndrome (PCOS) by altering the female brain's structure and function, with kisspeptin neurons and GABA neurotransmitters also playing a role.

More research is needed to understand how testosterone is maintained in adult males.

Androgens can cause hair growth in some areas but hair loss on the scalp.

Androgens can both increase body hair and cause scalp hair loss.

Finasteride reduces sperm count and quality and alters hormone levels in mice.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Women with PCOS have more body fat and thicker fat layers in certain abdominal areas than women without PCOS.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.

Young women with high male hormone levels or PCOS often feel more psychological distress and have a lower quality of life.

Suppressing certain hormones might help prevent prostate cancer.

HIV-infected men who have sex with men are at higher risk for aggressive syphilis, but treatment and tests are effective.

Long-term estrogen therapy in postmenopausal women can improve certain health markers, hair loss is common regardless of hormone use, stopping estrogen doesn't increase breast cancer risk, smoking does, and a balanced BMI is linked to lower mortality.

DHEA improved brain function and behavior in old monkeys and had additional health benefits.

Early signs of PCOS in girls, like irregular periods and polycystic ovaries, suggest a need for early diagnosis and intervention to prevent further health issues.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.