15 citations
,
November 2009 in “Journal of diabetes and its complications” This case highlights the potential link between type 1 diabetes, pernicious anemia, and alopecia areata universalis, suggesting clinicians should monitor for pernicious anemia in such patients.
12 citations
,
June 2006 in “Pediatric blood & cancer” This case report describes a 16-year-old male with pernicious anemia, autoimmune hemolytic anemia, and alopecia areata, highlighting the delayed diagnosis of the hemolytic anemia when cobalamin therapy failed to improve anemia symptoms.
12 citations
,
November 1970 in “Postgraduate Medical Journal” This article discusses the relationship between anemia and skin disease but does not present new research findings.
88 citations
,
February 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study reported that vitiligo patients in Turkey had a high prevalence of associated autoimmune diseases and auditory problems, suggesting vitiligo may be part of a systemic autoimmune process.
77 citations
,
August 1986 in “Archives of Dermatology” This report describes a case in which intramuscular cyanocobalamin treatment reversed skin and nail pigmentation changes and premature gray hair caused by vitamin B12 deficiency due to pernicious anemia.
15 citations
,
October 2013 in “Journal of the American Academy of Dermatology” This study found that in adults with vitiligo, certain autoimmune diseases are associated with factors like age, sex, and extent of vitiligo, suggesting tailored screening strategies based on these variables.
11 citations
,
August 1986 in “Archives of Dermatology” This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.
2 citations
,
January 2017 in “Journal of Pigmentary Disorders” This article discusses vitiligo, reviewing its symptoms, possible causes, and classification, but reports no new clinical findings.
2 citations
,
October 2016 in “Nutrition in clinical practice” This case report describes a rare instance of reversible melasma-like hyperpigmentation linked to vitamin B12 deficiency due to pernicious anemia, and explores possible mechanisms for this association.
2 citations
,
January 2014 in “Indian Journal of Critical Care Medicine” This report describes a 38-year-old female diagnosed with autoimmune polyendocrine syndrome Type II after presenting with shock.
1 citations
,
January 2013 in “Springer eBooks” The document concludes that skin and nail changes can indicate various underlying health conditions.
August 2025 in “Dermatology and Therapy” This study found that among US adults with vitiligo, the most prevalent autoimmune comorbidities were thyroid disease and alopecia areata, with evidence suggesting greater vitiligo extent increases prevalence of several autoimmune conditions.
May 2020 in “International journal of biology, pharmacy and allied sciences” This review discusses the correlation between vitiligo and various autoimmune, systemic, and dermatological diseases, highlighting the need to increase awareness of these comorbidities.
2 citations
,
January 2019 in “Springer eBooks” The conclusion is that different blood diseases cause specific oral symptoms and require varied treatments to manage these symptoms and improve patient health.
1 citations
,
April 1990 in “PubMed” This review discusses alopecia areata, including its associations, challenges in treatment assessment, and various therapies tried, without reporting new clinical results.
This study describes vitiligo as a chronic disorder where genetic, environmental, and immune factors contribute to skin depigmentation, with associations to other autoimmune diseases and potential links to oxidative stress.
August 2009 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” This article reviews the multifactorial etiology and treatment options for alopecia in children, including potential genetic and autoimmune contributions, but provides no new clinical findings.
December 2023 in “Paediatrics & Family Medicine/Pediatria & Medycyna Rodzinna” This article summarizes research on the co-occurrence of autoimmune diseases in patients with type 1 diabetes, noting that such conditions, present in up to 29% of these patients, can adversely impact their quality of life and diabetes management.
5 citations
,
April 1946 in “PubMed” This study found that a diet with purified casein and sulfasuxidine resulted in poor growth and anemia in a pig, which improved after treatment with a liver extract.
February 2022 in “Journal of Armed Forces Medical College” This case report details a patient with autoimmune hypothyroidism who experienced multiple health issues that improved with comprehensive treatment including Thyroxin replacement and other supportive measures.
July 2021 in “PARIPEX INDIAN JOURNAL OF RESEARCH” This study highlighted knuckle hyperpigmentation as an early sign of vitamin B12 deficiency, indicating a potential link to megaloblastic anemia in the vegetarian population in India.
100 citations
,
July 2018 in “Journal of The American Academy of Dermatology” This study found that alopecia areata is linked with a higher prevalence of systemic and psychiatric diseases, suggesting that physicians should monitor for these potential comorbidities.
50 citations
,
November 2010 in “Otolaryngologic Clinics of North America” This review discusses the oral manifestations associated with hematologic conditions and nutritional deficiencies, without presenting new research results; it emphasizes the impact of blood disorders and vitamin deficiencies on oral health.
January 2015 in “Endocrine updates” This chapter reviews the perioperative management and evaluation processes for bariatric surgery, emphasizing candidate selection, surgical risk reduction, and optimizing outcomes, and reports no new clinical results.
August 2023 in “Natural Resources for Human Health” This paper offers a detailed overview of B vitamins, detailing their importance for energy, cognition, and metabolism, conditions leading to their deficiencies, symptoms of deficiencies, and the foods rich in these essential nutrients.
September 2012 in “Annals of saudi medicine/Annals of Saudi medicine” This case report describes dizygotic twin sisters with congenital ichthyosis, mental retardation, myopathy, and anemia, who may represent a syndrome distinct from previously recognized disorders like Rud syndrome.
In this study conducted at a tertiary care hospital, the researchers observed that alopecia areata was more prevalent in males aged 21-30, typically presenting as single patches, with anemia being the most common associated systemic condition and lichen planus the most associated dermatological condition.
4 citations
,
January 2016 in “Annals of dermatology/Annals of Dermatology” Iron supplements can restore normal hair color in cases of premature graying linked to iron deficiency.
March 2026 in “International Journal of Clinical Dermatology” This study found that all 26 patients with specific skin lesions, primarily young females, were confirmed to have iron deficiency anemia after ruling out other possible causes such as zinc deficiency and pellagra, highlighting the importance of considering anemia as a diagnosis in such cases.
January 2020 in “Medpulse International Journal of General Medicine/Medpulse International Journal of Medicine” In this study, among 50 patients with premature hair graying, the combination of biotin, zinc, and calcium pantothenate showed no significant efficacy in treating the condition, and the researchers observed associations with other disorders such as anemia, alopecia areata, thyroid disorder, and vitiligo.