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Human skin can make serotonin and melatonin, which help protect and maintain it.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Niosomes improve minoxidil skin delivery for hair loss treatment.

Polymeric nanoparticles show promise for treating skin diseases.

Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Targeted cancer therapies often cause serious skin problems that need careful management.

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.

New effective scar treatments are urgently needed due to the current options' limited success.

Some medicinal plants can help heal wounds and may lead to new treatments.

Myrtle has various health benefits and potential for medicine development.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.