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Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

A woman's ovarian tumor causing high testosterone was successfully removed, and her symptoms improved.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Myoblast transplantation shows promise for treating various muscle and heart conditions.

Skin grafts are effective for chronic leg ulcers, especially autologous split-thickness grafts for venous ulcers, but more data is needed for diabetic ulcers.

PEGylated liposomal doxorubicin improves cancer treatment effectiveness and reduces side effects like heart damage and hair loss.

The conclusion is that effective cancer treatment often requires a combination of therapies, but must be carefully managed due to serious side effects and the risk of immunosuppression.

Gemcitabine and paclitaxel are effective and safe as first-line treatment for metastatic breast cancer.

CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.

Melatonin given to pregnant rabbits improved their babies' fur quality.

New partnerships, clinical trials, and drug approvals marked progress in therapeutic delivery in July 2018.

Tacrolimus causes fewer acute rejections than cyclosporin A in kidney transplants but doesn't necessarily improve kidney function after one year; cardiovascular risks and side effects vary between the two drugs.

Dextran sulfate was found to be toxic and ineffective for treating HIV.

Hydroxychloroquine showed some potential, but overall, the three drugs had limited success in treating lupus in dogs.

The spiny mouse is a unique menstruating rodent that can help us understand menstruation and reproductive disorders.

The dermal regeneration template is effective in skin regeneration, reducing scarring, and has potential for future improvements.

The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.

Human hair has more unsaturated fats inside than on the surface, and certain lipids may help bind the outer and inner layers together.

The document concludes that cosmetics need biocompatible, eco-friendly ingredients due to aging populations and demand for effective products.

Some men with early hair loss may have a male version of PCOS, affecting hormones and increasing health risks.

The skin has multiple layers and cells, serves as a protective barrier, helps regulate temperature, enables sensation, affects appearance, and is involved in vitamin D synthesis.

More high-quality research is needed to recommend flavonoids and saponins for clinical use.

3D bioprinting is advancing in plastic and reconstructive surgery, especially for creating tissues and improving surgical planning, but faces challenges like vascularization and material development.

Certain gene variations and different levels of BDNF and CRH hormones are linked to vitiligo.

The document concludes that understanding how adult stem and progenitor cells move is crucial for tissue repair and developing cell therapies.

Sonicated platelet-rich plasma boosts hair growth by activating stem cells.

Scientists found a new, less invasive way to get stem cells from horse hair for veterinary medicine.

The guide explains how to study human skin fat cells and their tissue, aiming to improve research and medical treatments.

MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.

The document concludes that treatment for cutaneous T-cell lymphoma should be customized to each patient's disease stage, balancing benefits and side effects, with no cure but many patients living long lives.