December 2022 in “International Journal of Women's Dermatology” This study reported that using the Sinclair Shedding Scale and intralesional corticosteroid injections may help diagnose and manage alopecia areata incognita in women experiencing excessive hair shedding without clear diagnostic indicators.
January 2022 in “Indian Journal of Paediatric Dermatology” This case study reports that patchy nonscarring alopecia without systemic involvement can be an atypical initial indication of juvenile onset systemic lupus erythematosus.
September 2017 in “Journal of Investigative Dermatology” RCS-01 is safe and may help rejuvenate aging skin.
January 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This report discusses the Ninth World Congress for Hair Research and highlights the potential of hair follicle studies to advance understanding of various diseases, with no new clinical results presented.
December 2020 in “Galen Medical Journal” This study observed that patients with alopecia areata and androgenic alopecia have significantly more perifollicular and perivascular mast cells compared to healthy individuals, particularly in those over 40 and with greater disease severity.
July 2021 in “IntechOpen eBooks” This review discusses the potential of ginseng and its metabolites for treating hair loss and reports no new clinical findings.
143 citations
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January 2007 in “The American Journal of Human Genetics” This study identified four genetic loci on chromosomes 6, 10, 16, and 18 that may contribute to susceptibility for alopecia areata and suggested shared genetic factors with psoriasis.
56 citations
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August 2019 in “Clinical, Cosmetic and Investigational Dermatology” This essay discusses telogen effluvium, the issues surrounding its diagnosis and differentiation from other forms of hair loss, and emphasizes the need for empathetic patient care; it reports no new clinical findings.
47 citations
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December 2003 in “Journal of Investigative Dermatology” DS cells in hair follicles can help form and restore hair, especially in hair loss conditions.
45 citations
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May 2024 in “International Journal of Molecular Sciences” This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.
40 citations
,
June 2021 in “Clinical, cosmetic and investigational dermatology” This review explores the efficacy and outcomes of using JAK inhibitors for treating alopecia areata, noting advancements in understanding the disease's pathomechanisms and suggesting that JAK inhibitors may offer targeted therapeutic benefits by blocking specific inflammatory pathways involved in this chronic condition.
37 citations
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October 2014 in “JAMA dermatology” This case report describes a woman with alopecia universalis, resistant to multiple treatments, who experienced successful hair regrowth with adalimumab, suggesting potential mechanisms for future investigation.
30 citations
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November 2012 in “Anais Brasileiros De Dermatologia” This review discusses chronic telogen effluvium and diffuse alopecia areata, providing clinical and diagnostic insights, but presents no new clinical findings.
21 citations
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December 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrates that T-cell responses in extensive alopecia areata scalp may be aberrantly regulated, with reduced cytokine production but activated phenotype, providing insight into the disease's immune mechanisms.
19 citations
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January 2015 in “Skin appendage disorders” This study identified a new variety of central centrifugal cicatricial alopecia that includes patchy hair loss on the lateral and posterior scalp in African-American women, which could be misdiagnosed as traction alopecia without dermatoscopy and pathology.
16 citations
,
July 2019 in “Biochemical and Biophysical Research Communications” This study concluded that CD36-expressing dermal sheath cells may influence the modulation of blood capillaries in hair follicles, potentially affecting hair cycling.
9 citations
,
August 2015 in “Tissue Engineering and Regenerative Medicine” In this study, human dermal stem/progenitor cell-derived conditioned medium was found to promote hair regrowth in mice, possibly through effects on the Wnt/β-catenin pathway.
8 citations
,
October 2022 in “Regenerative Therapy” This review discusses regenerative medicine approaches for treating alopecia, including mesenchymal stem cell therapies and platelet-rich plasma, but reports no new clinical results, emphasizing the need for further study.
5 citations
,
March 2025 in “Pediatric Dermatology” This study found that alopecia areata is linked to genetic factors, specifically HLA haplotypes on chromosome 6, and involves immune privilege collapse at hair follicles which is mediated by the JAK-STAT pathway and pro-inflammatory cytokines like IFN-γ.
4 citations
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October 2022 in “Genes” This review discusses the role of cutaneous and intestinal microbiota in the development of alopecia areata, summarizing current literature without reporting new clinical results.
2 citations
,
January 2023 in “Journal of Clinical Medicine” This review discusses the links between different types of alopecia and thyroid disorders, highlighting some shared autoimmune factors, but reports no new clinical results.
2 citations
,
August 2022 in “Clinical Case Reports” This case report describes a 17-year-old girl with telogen effluvium and severe hair loss following a suspected COVID-19 infection and a history of similar episodes since childhood.
1 citations
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September 2024 in “Life” This study reports three cases of alopecia areata resistant to corticosteroids that improved after 16 weeks of treatment with a combination of fractional carbon dioxide laser and topical tacrolimus, suggesting a potential new therapeutic option that requires further confirmation.
1 citations
,
February 2024 in “JEADV Clinical Practice” This study reviewed 20 studies and found that pulse corticosteroid therapy led to complete hair regrowth in 38.53% of patients with severe alopecia areata, but came with many unwanted side effects.
1 citations
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September 2023 in “JAAD case reports” In this case report, mogamulizumab treatment for Sézary syndrome was associated with rashes and alopecia in a patient, highlighting the potential for immune-mediated side effects and suggesting that such adverse effects might indicate a favorable prognosis, though further studies are needed.
1 citations
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January 2022 in “Stem cell biology and regenerative medicine” This review discusses the potential of cell therapies using dermal papilla and dermal sheath cells for androgenetic alopecia, highlighting their ability to reverse hair follicle miniaturization but not yet achieving significant cosmetic efficacy in trials.
1 citations
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January 2018 in “Indian journal of dermatopathology and diagnostic dermatology” This review discusses the use of trichoscopy as a valuable diagnostic and prognostic tool for various hair and scalp disorders, reporting no new clinical results.
May 2026 in “International Journal of Molecular Sciences” This review highlights emerging evidence that chemotherapy-induced alopecia may be driven by immune mechanisms similar to alopecia areata, involving hair follicle immune privilege collapse, and evaluates Janus kinase inhibitors as potential treatments, while cautioning about their immunosuppressive risks in cancer patients.
February 2026 in “Journal of Craniofacial Surgery Open” This narrative review outlines the biological costs of hair extensions, such as traction leading to hair loss and scalp issues, and suggests a prevention-focused model involving risk assessment, surveillance, and tiered therapies to minimize alopecia risk and maintain scalp health.
January 2026 in “Cosmetics” This study highlights emerging regenerative strategies, such as stem cell-derived therapies and machine learning tools, that may advance hair loss treatment beyond traditional methods by promoting follicle regeneration and offering personalized care.