208 citations
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January 2013 in “Lab on a Chip” The researchers described a chip-based bioreactor platform for dynamic perfusion, which may enhance in vitro skin models by introducing mechanical shear stress and extending culture periods.
14 citations
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April 2017 in “Scientific Reports” This study demonstrated that using a perfusion culture bioreactor and 3D spheroid culture can enhance corneal endothelial cell expansion and support the construction of tissue-engineered corneal endothelial layers in vitro.
December 2024 in “Journal of Clinical Medicine” This study found that wound bed perfusion strongly predicts skin graft viability by correlating with lower necrosis extension on both the scalp and lower limb, unlike perfusion of the wound margin and donor skin, which showed no significant correlation.
4 citations
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October 2022 in “International Journal of Molecular Sciences” In this study, Thy-1 was observed to play a critical role in wound healing in mice, particularly influencing vascular dynamics and blood perfusion during the healing process.
June 2026 in “Journal of Cutaneous and Aesthetic Surgery” This review proposes an anatomy-based framework for understanding recipient site scalp necrosis in hair transplantation, emphasizing regional vascular vulnerability and surgical factors, but does not provide new clinical results.
July 2004 in “Journal of Clinical Oncology” This study found that therapeutic isolated limb perfusion with melphalan for in-transit melanoma metastases resulted in a high response rate but was associated with some systemic toxicity, including nausea, vomiting, and transient bone marrow depression.
July 2004 in “Journal of Clinical Oncology” This study found therapeutic isolated limb perfusion with melphalan to be effective for in-transit melanoma metastases on a limb, with a high response rate and transient systemic toxicity.
November 2022 in “Current Psychology” This study found that health ads are more persuasive when matched with consumers' fresh start mindset, with progression ads suiting a weak mindset and before/after ads suiting a strong mindset.
203 citations
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July 2017 in “Biotechnology and Genetic Engineering Reviews” This review discusses the various components essential for successful tissue engineering, such as cell sources, modification methods, and supportive matrices, and highlights the need for functional synergy without reporting new experimental results.
1 citations
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October 2025 in “Current Issues in Molecular Biology” This research found that escin, when applied topically, enhances blood flow in human skin and promotes changes in endothelial cell signaling pathways, suggesting potential benefits for improving cutaneous microcirculation.
July 2026 in “Frontiers in Bioengineering and Biotechnology” This mini-review reports that advances in microbioreactor technology, particularly with microfluidics, significantly enhance eukaryotic cell-based biomedicine by improving productivity, scalability, and reproducibility in applications like CAR T-cell manufacturing and organoid growth, though challenges in scalability and material selection remain.
25 citations
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May 2020 in “Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine” This article discusses the potential benefits of platelet-rich plasma injections in ovarian tissue to improve reproductive outcomes in IVF for older individuals and proposes a mechanism to enhance embryo ploidy rescue, but reports no new clinical results.
24 citations
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January 2020 in “International Journal of Molecular Sciences” This review discusses the potential benefits of flavonoid-containing botanicals, such as Panax ginseng, in reducing hair loss and promoting hair growth, but reports no new experimental results.
13 citations
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January 2022 in “Microvascular Research” This study found that high-resolution laser speckle contrast imaging devices provide good reproducibility for assessing skin perfusion in mice but not for measuring haemoglobin oxygenation.
11 citations
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July 2017 in “Expert Opinion on Investigational Drugs” This review discusses current and emerging therapeutic strategies for androgenetic alopecia, noting limited evidence but suggesting areas such as prostaglandin analogs, PRP, and progenitor cell therapies as promising future directions.
6 citations
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October 2021 in “Indian Journal of Plastic Surgery” In this study, eyebrow restoration using FUE-harvested single hair follicle grafts was explored, emphasizing the importance of donor hair selection, placement technique, and postoperative care in achieving optimal results, while highlighting challenges such as scarring and skin perfusion.
5 citations
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March 2018 in “Clinics in Dermatology” This study found that combined platelet-rich plasma injections and suture embedding significantly improved scalp thickness, blood flow, and hair diameter in patients with androgenetic alopecia.
3 citations
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July 2022 in “Stem Cell Research & Therapy” This study found that knocking out the integrin β1 subunit in induced pluripotent stem cells enhanced their migration and improved their wound-healing effects in a mouse model.
2 citations
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November 2019 in “BMC urology” This study used micro-CT to visualize preputial vessel distribution in a congenital hypospadias rat model, revealing that vessels at the preputial junction with good circulation were well-suited for vascular pedicle flaps in surgery.
1 citations
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May 2007 in “Chinese Medical Journal” This case report describes a 24-year-old woman with a rare giant cerebriform pigmented nevus on the scalp, which was identified as a giant congenital intradermal nevus based on clinical and pathological findings.
June 2026 in “Frontiers in Bioengineering and Biotechnology” This review outlines the transition from simple hair follicle organoids to immune-competent microphysiological systems, addressing limitations in replicating native hair follicle immune features and discussing their applications in disease modeling and regenerative medicine.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This paper introduces the Vertex Overload Framework for androgenetic alopecia, suggesting that chronic mechanical and thermal stress on the vertex contributes to hair follicle miniaturization, with androgens acting as co-mediators of stress adaptation rather than isolated causes.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This study offers a new perspective on androgenetic alopecia, suggesting that hair loss at the vertex and frontal scalp results from mechanical and thermodynamic stress, alongside androgen activity, and proposes that reducing mechanical tension and improving local microcirculation could complement traditional treatments.
February 2025 in “Brazilian Journal of Hair Health” This study found that multiparametric ultrasound effectively detects real-time scalp changes caused by vasoconstrictive cosmetic agents, demonstrating its potential as a non-invasive tool for evaluating trichological treatments.
Some TikTok hair loss remedies like rosemary oil, onion juice, and garlic gel show promise, but more research is needed and they might delay proper treatment.
March 2022 in “IntechOpen eBooks” This chapter discusses the potential therapeutic applications of Botulinum toxin for various non-cosmetic skin conditions, such as acne, rosacea, and hyperhidrosis, highlighting case reports and some randomized controlled trials that indicate promise in alleviating discomfort, inflammation, and excessive sweating.
October 2019 in “Research Square (Research Square)” This study found that micro-CT imaging can effectively identify vascular structures in rat models of congenital hypospadias, providing anatomical insights for selecting preputial vessel flaps in surgical procedures.
This study observed that the extract of Ginseng Radix et Rhizoma promoted hair growth in C57BL/6J mice by enhancing local perfusion and inhibiting platelet aggregation.
7 citations
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July 2016 in “PubMed” This study found that laser Doppler velocimetry can non-invasively predict topical minoxidil response by correlating scalp blood flow changes with sulfotransferase enzyme activity in women with pattern hair loss.