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The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Sebocytes play a key role in controlling androgen levels in human skin.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

DHT may increase the risk of heart disease and death in elderly men.

Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.

Spironolactone is effective for treating acne, hirsutism, and androgenic alopecia in women with few side effects.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Hair follicle regeneration needs special conditions and young cells.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Best hair growth results from combining finasteride and minoxidil.

Norgestimate is the most effective birth control progestin for reducing an enzyme linked to acne and excessive hair growth in women.

Minoxidil promotes hair growth but stops working when discontinued.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

New treatments for male hypogonadism are effective and should be personalized.

Liver transplantation is a viable option for children with propionic acidemia, improving quality of life and diet, but does not remove all risks and long-term brain outcomes are uncertain.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.