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A man with testotoxicosis was fertile despite low FSH levels, suggesting high testosterone may allow sperm production without FSH.

The document concludes that better research methods are needed in men's sexual health to provide stronger evidence and improve patient care.

The conclusion is that off-label drug use can lead to important medical discoveries and improve patient care.

Menopause often leads to lower sexual desire and discomfort during sex, but treatment should be personalized and only if it bothers the woman.

Hormones significantly affect women's sexual function, and more research is needed to improve treatments for sexual dysfunction with minimal side effects.

An elderly man with dementia suffered limb damage from rubber bands around his leg, highlighting the need for careful monitoring to prevent such injuries.

Aminopterin effectively improves skin conditions but has toxic side effects that need careful monitoring.

Lichen planopilaris in men often involves scalp redness and itching, with some also having hair loss, mucosal lichen planus, or thyroid disease, and treatment improved symptoms in nearly half of the cases.

5-alpha reductase inhibitors can cause sexual, neurologic, endocrine, and cardiovascular side effects, but these are rare and usually stop after ending treatment.

Tadalafil is effective for treating urinary symptoms in men with BPH.

Diagnosing simple-virilizing congenital adrenal hyperplasia can be difficult and requires thorough testing and expert advice.

Metreleptin treatment significantly improved metabolic health in a boy with congenital generalized lipodystrophy.

Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.

Hidradenitis Suppurativa is a chronic skin condition best treated early with surgery for better outcomes and less recurrence.

Educating healthcare workers and parents about hair toe tourniquets can help prevent serious complications.

Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Some drugs have gained approval for new uses, while others like tricyclic antidepressants and aspirin show promise but aren't yet approved for these uses.

Finasteride may decrease semen quality but not harm sperm production, and stopping the drug can improve semen quality; hyperprolactinemia can cause infertility but is treatable with medication.

Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.

A 25-year-old Malay fireman had skin bumps on his neck that were removed successfully after other treatments failed.

Dihydrotestosterone gel before hypospadias surgery led to less scarring but raised concerns about potential psychological effects and skin changes.

Future hormone therapy trials should match the diverse needs and priorities of the gender-diverse community.

More research is needed to find effective treatments for sickle cell disease-related priapism.

A young man with high-grade prostate cancer had successful surgery and good recovery, highlighting the need for awareness in younger men.

Lichen planus is a chronic autoimmune disease that is hard to treat and more common in women.

The patient has a rare skin condition that shows features of two known disorders.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

Longer anogenital distance may indicate a higher chance of having polycystic ovary syndrome, and measuring this distance along with hormone levels could improve diagnosis.

Removing a testicular tumor in a dog reduced its aggressive behavior and skin problems.