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Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Testosterone's muscle-building effects do not require its conversion to DHT.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Rats had lasting erectile problems after stopping a certain medication.

Finasteride temporarily lowers male rat fertility without affecting libido.

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

Potassium channel openers show promise for treating heart disease and other conditions, but more research is needed to fully understand their effects and safety.

Finasteride can cause sexual problems and depression in young men.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride may increase erectile dysfunction risk in patients with benign prostatic hyperplasia.

Finasteride worsens erectile dysfunction and lowers testosterone in men with enlarged prostates, unlike tamsulosin.

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

Negative expectations can cause adverse effects in dermatology treatments, like with finasteride for baldness, and careful communication can help reduce these nocebo responses.

Men's age, urinary symptoms, and heart health risks create different types of erectile dysfunction.

Nandrolone might increase muscle mass with fewer side effects than testosterone but could cause erectile dysfunction and needs more research.

More hair loss leads to higher risk of psychosexual disorders, especially in women.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.