59 citations
,
July 2015 in “Journal of innovative optical health sciences/Journal of innovation in optical health science” This review examines the potential of nanoparticles for localized drug delivery via hair follicles but reports no new clinical results, with the authors noting a lack of commercial development despite research progress.
59 citations
,
January 2015 in “Nanoscale” In this study, polymeric micelles containing retinoic acid were found to improve targeted delivery to hair follicle structures in human skin more efficiently than a marketed retinoic acid gel, suggesting potentially safer and more effective acne treatment.
research ACNE
58 citations
,
January 1997 in “Dermatologic Clinics” This study found that daily consumption of soft drinks significantly increases the risk of moderate-to-severe acne in adolescents, particularly if sugar intake from these drinks exceeds 100 grams per day.
57 citations
,
March 2011 in “Pediatric Dermatology” In this study, skin manifestations were observed in 48% of children with primary immunodeficiency disorders, often providing crucial diagnostic clues for early identification of these conditions.
55 citations
,
June 2009 in “Journal of Pharmaceutical Sciences” This study found that ethanol-containing formulations significantly increased minoxidil retention in the stratum corneum and appendages initially, while a propylene glycol-rich formulation enhanced deeper skin penetration over time.
55 citations
,
October 1992 in “Archives of Dermatology” In this study, researchers observed that loose anagen hair syndrome is an autosomal dominant disorder characterized by abnormal hair follicle structure and premature keratinization, possibly due to signaling and desmosomal component disturbances.
54 citations
,
September 1972 in “British journal of nutrition” Malnutrition severely harms growth and development in young baboons.
52 citations
,
June 1981 in “International Journal of Dermatology” Oral retinoids are effective for severe skin conditions but require careful use due to side effects.
51 citations
,
September 2020 in “Cell Metabolism” This study highlights that the mammalian target of rapamycin complex 2 (mTORC2)-Akt signaling axis is essential for hair follicle stem cells to return to their niche and regenerate effectively by regulating metabolic pathways.
51 citations
,
November 2018 in “JAMA Dermatology” This study found that participant self-assessments suggested greater improvement in the texture and wrinkles of facial skin treated with PRP compared to normal saline, though dermatologist ratings showed no significant difference.
51 citations
,
September 2015 in “Medical Clinics of North America” This review discusses common skin appendage diseases, including their pathophysiology and treatments, but does not report new results.
50 citations
,
February 2018 in “Biomedicine & pharmacotherapy” This review discusses the anticancer properties of ginseng, including its potential to alleviate chemotherapy side effects, and calls for more research on its mechanisms of action in various cancers.
49 citations
,
June 2009 in “Seminars in Cutaneous Medicine and Surgery” This article examines differences in aging among ethnic populations and highlights cosmetic procedures specific to skin of color, but reports no new research findings.
49 citations
,
August 2007 in “Dermatologic surgery” This review discusses newer therapeutic techniques for treating postacne scarring, highlighting their effectiveness for particular grades of scars, and reports no new clinical results.
48 citations
,
February 2025 in “Nano-Micro Letters” This review summarizes the application of microneedles in treating various skin diseases and highlights challenges like low drug loading, noting no new clinical results are reported.
48 citations
,
July 2001 in “Clinics in Dermatology” Cosmetics enhance beauty, fix defects, and intimidate enemies, with varying cultural standards and alternative methods.
48 citations
,
November 1992 in “International Journal of Dermatology” This article discusses the history and terminology of toxic epidermal necrolysis but reports no new clinical results.
47 citations
,
June 2015 in “Medicines” This review examines the use and efficacy of Panax ginseng in various clinical settings, noting that clinical trial outcomes vary widely based on study conditions and ginseng types; no new results are reported.
42 citations
,
September 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the distinct clinical and psychological aspects of adult female acne and reports no new clinical results, highlighting the need for a comprehensive management approach.
42 citations
,
February 2017 in “Dermatologic surgery” This study found that VYC-15L (Juvéderm Volbella XC) was safe and effective for enhancing lip and perioral areas, achieving higher lip fullness improvement and fewer severe injection site reactions compared to NASHA, with effects lasting up to one year.
42 citations
,
April 2012 in “Seminars in Oncology” This review discusses the skin side effects associated with targeted cancer therapies and reports no new clinical results; it emphasizes the need for empirical management based on expert opinion.
42 citations
,
March 2006 in “Drug Discovery Today: Therapeutic Strategies” This article discusses the need for rational strategies in developing hair loss drugs targeting specific events in hair follicle cycling, reporting no clinical findings but emphasizing the importance of understanding molecular controls.
41 citations
,
November 2011 in “The Journal of Dermatology” This review identifies genetic mutations associated with congenital hair loss disorders in Japanese populations, particularly highlighting common LIPH gene mutations linked to woolly hair/hypotrichosis, and reports no new clinical results.
39 citations
,
September 2013 in “Journal of Cosmetic Dermatology” This review summarizes causes and treatments of androgenetic alopecia with a focus on herbs as potential alternatives, but reports no new results and suggests more research is needed to validate these options.
39 citations
,
May 2004 in “Clinics in Dermatology” This article reviews treatment options for cutaneous T-cell lymphoma, including skin-directed therapies and aggressive treatments for advanced cases, but reports no new clinical results.
37 citations
,
January 2011 in “Annals of Dermatology” In this study, photodynamic therapy significantly reduced inflammatory acne lesions and sebum secretion, possibly by inducing apoptosis in sebaceous glands and down-regulating TLR-2 and TLR-4 expression.
36 citations
,
December 2015 in “Drugs” This review summarizes various drug treatments for hidradenitis suppurativa, noting their effectiveness, side effects, and high recurrence rates, but reports no new clinical findings.
35 citations
,
January 2019 in “Clinics in Dermatology” This review discusses contemporary issues in syphilis diagnosis and management, emphasizing the importance of recognizing and addressing both biomedical and psychosocial aspects, but provides no new clinical results.
35 citations
,
January 2018 in “Skin pharmacology and physiology” This study found that nanoemulsion formulations with oleic acid or eucalyptol significantly enhanced the delivery and retention of caffeine through hair follicles and surrounding skin regions.
35 citations
,
April 2006 in “Ocular Surface” This review discusses adverse effects of cosmetic products and procedures on the ocular surface, including mild discomfort to severe vision-threatening conditions, and reports no new clinical results.