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The NUDT15 R139C variant causes thiopurine-induced leukocytopenia through a different mechanism than previously thought in Japanese patients with inflammatory bowel disease.

Persistent radiation-induced hair loss is dose-dependent, and treatments like topical minoxidil can be effective.

Tofacitinib is an effective and safe treatment for alopecia areata.

The review suggests doctors should carefully weigh risks and benefits of off-label drug use, involve patients in decisions, and calls for better regulations and monitoring.

Serenoa repens (saw palmetto) may cause side effects like hot flashes in children and needs more research for safety in pediatric use.

Genetic variants can affect valproic acid's effectiveness, side effects, and levels in epilepsy treatment.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

The document concludes that doctors should carefully consider off-label drug use in dermatology and always inform patients, while more research is needed on the safety and effectiveness of such practices.

Psychotropic medications can cause skin problems, including serious conditions, and patients should be monitored closely.

Liver transplant can lead to neurological, pulmonary, cardiovascular, and renal complications, with older patients facing higher risks.

Get head MRI for babies with achondroplasia early, use free immunoglobulin light chains to detect certain neurodevelopmental disorders, and video calls work for speech therapy in patients with facial anomalies.

The FDA warned about safety issues with remdesivir and tofacitinib, finasteride is linked to suicidality, potent topical corticosteroids increase osteoporosis risk, henna can cause hemolysis in G6PD deficiency, chemotherapeutic agents can cause adverse reactions, drug interactions are common in cancer patients, ketamine can reduce at-risk drinking, high dose of anticholinergics increases dementia risk in Parkinson's patients, and prenatal exposure to second-generation antipsychotics increases pregnancy complications.

Minoxidil helps lower high blood pressure in kids, but can cause fluid retention and hair growth.

Trichoscopy is essential for diagnosing and managing alopecia areata in children.

Atopic dermatitis significantly lowers the quality of life for infants and their families.

The conclusion is that effective cancer treatment often requires a combination of therapies, but must be carefully managed due to serious side effects and the risk of immunosuppression.

The most common cause of hair loss in children is tinea capitis, followed by alopecia areata and telogen effluvium.

Loose anagen hair syndrome, often affecting young girls, can be diagnosed with a hair-pull test and usually gets better on its own, but severe cases may need treatment.

Injecting platelet-rich plasma or applying it with a laser or microneedling can treat hair loss effectively. The laser and microneedling methods cause less pain.

More research is needed to find effective treatments for sickle cell disease-related priapism.

People with HIV and low T cell counts have more hair and scalp problems.

A vibrating anesthetic device significantly reduces pain during mesotherapy for hair loss without complications.

Cyclosporine may cause hair loss, so patients need monitoring.

308 nm excimer light therapy may help hair regrowth in alopecia areata with delayed results and no serious side effects.

The UD-PrOZA program successfully diagnosed 18% of adult patients with rare diseases, often using genetic testing.

Trichoscopy is useful for correctly diagnosing tinea capitis in adults with unexplained hair loss.

Eczema and fungal infections are the most common skin problems in Japan, with different age groups and genders affected by various conditions.

Tofacitinib is a promising treatment for severe alopecia areata, with many patients experiencing complete or partial hair regrowth.

Divalproex sodium can unexpectedly cause agitation and hyperactivity in some patients.

Tofacitinib helped some young children with severe hair loss grow their hair back without bad side effects.