19 citations
,
September 2013 in “Molecular Medicine Reports” In this study, researchers developed a method to efficiently derive contractile smooth muscle cells from human hair follicle stem cells using TGF-β1 and PDGF-BB, which may advance vascular tissue engineering.
18 citations
,
July 2007 in “Hair transplant forum international” This study reported that using platelet-rich plasma as a storage medium for hair grafts in hair restoration surgery may improve graft survival rates and accelerate healing.
17 citations
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February 2015 in “International Journal of Molecular Sciences” This study found that keratinocyte stem/progenitor cell-conditioned medium significantly enhanced hair growth in mice and increased the proliferation of human hair follicle cells.
17 citations
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May 2005 in “Hair transplant forum international” This study evaluated the effectiveness of follicular units and growth factors derived from autologous platelet-rich plasma in improving hair growth and density in 23 male patients with pattern hair loss.
16 citations
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October 2018 in “Biochemical and Biophysical Research Communications” In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.
14 citations
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March 2019 in “Journal of Cosmetic Dermatology” This laboratory study found that activated platelet‐rich plasma supernatant enhanced hair growth signaling pathways in cultured human dermal papilla cells, suggesting potential for treating androgenic alopecia.
11 citations
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July 2004 in “Journal of Investigative Dermatology” Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.
10 citations
,
August 2020 in “Journal of Bioscience and Bioengineering” This study reports that using activated platelet-rich plasma releasate in the preparation of bioengineered hair follicle germs enhanced follicular gene expression and significantly improved hair regeneration in vitro.
8 citations
,
July 2019 in “Cell Proliferation” In this study, researchers developed a chemical cocktail and suspension culture method to transform human dermal fibroblasts into dermal papilla-like cells capable of inducing hair follicle formation in vitro and in vivo.
7 citations
,
December 2013 in “The Journal of Dermatology” This article is a letter to the editor discussing hair graying and loss potentially induced by imatinib mesylate, but it does not provide new research results.
6 citations
,
December 2023 in “Journal of Clinical Medicine” This review explores the potential link between psoriasis and metabolic syndrome, focusing on how disturbances in growth factors may connect these conditions and contribute to symptoms like keratinocyte proliferation and inflammation.
6 citations
,
June 2020 in “Journal of Drugs in Dermatology” This review discusses the use of platelet-rich plasma for treating various types of alopecia, reporting promising preliminary hair regrowth results but noting a lack of quantitative evidence from well-designed clinical trials.
6 citations
,
June 2017 in “Asian journal of beauty & cosmetology” In this study, Rosa multiflora root extracts showed strong antioxidant activity and promoted expression of growth factors IGF1 and PDGFB, suggesting potential use as a natural hair growth agent.
5 citations
,
June 2024 in “Regenerative Therapy” This study found that freezing PRP at -80 °C for up to a year maintains most growth factor levels, with EGF and IGF even higher than in fresh samples.
5 citations
,
February 2023 in “Frontiers in Veterinary Science” This study found that ovine dermal papilla cells exhibit robust aggregation and alkaline phosphatase activity, regulated by Wnt/β-catenin signaling, providing insights for improving wool performance and hair regeneration therapies.
5 citations
,
September 2019 in “ACS Applied Bio Materials” This study developed a composite hydrogel that delivered multiple proteins, enhancing skin wound healing by accelerating closure and promoting hair follicle regeneration.
5 citations
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January 2013 in “Otorhinolaryngology clinics : an international journal” This review discusses the use of platelet-rich plasma in cosmetic surgery, highlighting its expanding applications and promising potential in aesthetic treatments, but reports no new empirical findings.
5 citations
,
January 2004 This paper describes the cellular and molecular processes involved in dermal tissue repair and reports no new experimental results.
3 citations
,
April 2021 in “PLoS ONE” The authors concluded that controlling voltage, pulse width, and calcium concentration in pulse electric field-activated platelet-rich plasma enhances the release of growth factors and serotonin without causing clot formation, suggesting potential clinical advantages over bovine thrombin-activated PRP.
3 citations
,
March 2019 in “American Journal of Dermatopathology” This case report presents the first documented instance of basal cell carcinoma and cutaneous leiomyosarcoma occurring as a collision neoplasm in the same biopsy specimen.
2 citations
,
May 2022 in “Journal of trace elements in medicine and biology” This study found that administering lower doses of sodium pentaborate pentahydrate increased hair growth in rats via specific molecular pathways, while a higher dose suppressed these pathways and impaired hair growth.
2 citations
,
December 2019 in “Nanoscience and Nanotechnology Letters” In a study on the effects of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) on hair growth in nude mice, researchers found that both treatments promoted hair growth, with SVF showing a stronger effect.
2 citations
,
November 2019 in “FEBS open bio” This study found that stimulating dermal papilla cells with specific adipo-osteogenic factors and growth factors helped maintain their viability and restored their hair-forming activity in vitro.
1 citations
,
October 2024 in “European Journal of Histochemistry” In this study, researchers reported telocytes in the dermis of silky fowl embryos at different developmental stages, highlighting their immunophenotypes and interactions with other cells.
1 citations
,
July 2023 in “International Journal of Molecular Sciences” This study found that a hypoxic microenvironment enhanced the proliferation and pluripotency of adipose mesenchymal stem cells, promoting hair follicle formation and upregulating specific growth factors in Arbas Cashmere goats.
1 citations
,
January 2023 in “Journal of research in pharmacy” This study found that the methanolic extract of Carduus adpressus exhibited strong antibacterial, antioxidant, and wound-healing activities, suggesting its potential use in developing wound-healing agents.
1 citations
,
April 2018 in “Journal of Investigative Dermatology” In this study, researchers found that the variability in growth factor expression, particularly TGFβ1, in PRP samples could influence patient responses to hair loss treatment with PRP therapy.
1 citations
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August 2016 in “Dermatology - Open Journal” In this study, the researchers found that optic atrophy 1 (OPA1) is involved in the transition between filamentous and rounded mitochondria in hair follicle dermal papilla cells, potentially influencing cellular energy dynamics.
April 2026 in “International Journal of Dermatology” This review explores the potential links between PRP treatments for hair loss and scalp skin cancer risk, finding current evidence supports PRP's safety but emphasizes the need for further studies and routine monitoring.
March 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed a new method called Enriched-GF, which enhances growth factor recovery from platelet concentrates through a combination of glass bead activation, freeze-thaw cycling, and calcium stimulation, outperforming conventional methods by providing higher and more consistent yields for regenerative medicine applications.